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Items: 1 to 20 of 104


The distribution of fitness effects of new deleterious amino acid mutations in humans.

Eyre-Walker A, Woolfit M, Phelps T.

Genetics. 2006 Jun;173(2):891-900. Epub 2006 Mar 17.


Estimating the Fitness Effects of New Mutations in the Wild Yeast Saccharomyces paradoxus.

Koufopanou V, Lomas S, Tsai IJ, Burt A.

Genome Biol Evol. 2015 Jun 16;7(7):1887-95. doi: 10.1093/gbe/evv112.


Estimating selection on nonsynonymous mutations.

Loewe L, Charlesworth B, Bartolomé C, Nöel V.

Genetics. 2006 Feb;172(2):1079-92. Epub 2005 Nov 19.


A method for inferring the rate of occurrence and fitness effects of advantageous mutations.

Schneider A, Charlesworth B, Eyre-Walker A, Keightley PD.

Genetics. 2011 Dec;189(4):1427-37. doi: 10.1534/genetics.111.131730. Epub 2011 Sep 27.


Assessing the evolutionary impact of amino acid mutations in the human genome.

Boyko AR, Williamson SH, Indap AR, Degenhardt JD, Hernandez RD, Lohmueller KE, Adams MD, Schmidt S, Sninsky JJ, Sunyaev SR, White TJ, Nielsen R, Clark AG, Bustamante CD.

PLoS Genet. 2008 May 30;4(5):e1000083. doi: 10.1371/journal.pgen.1000083.


Inferring the distribution of mutational effects on fitness in Drosophila.

Loewe L, Charlesworth B.

Biol Lett. 2006 Sep 22;2(3):426-30.


What can we learn about the distribution of fitness effects of new mutations from DNA sequence data?

Keightley PD, Eyre-Walker A.

Philos Trans R Soc Lond B Biol Sci. 2010 Apr 27;365(1544):1187-93. doi: 10.1098/rstb.2009.0266.


Surprising fitness consequences of GC-biased gene conversion: I. Mutation load and inbreeding depression.

Glémin S.

Genetics. 2010 Jul;185(3):939-59. doi: 10.1534/genetics.110.116368. Epub 2010 Apr 26. Erratum in: Genetics. 2012 Apr;190(4):1585.


Inferring selection on amino acid preference in protein domains.

Moses AM, Durbin R.

Mol Biol Evol. 2009 Mar;26(3):527-36. doi: 10.1093/molbev/msn286. Epub 2008 Dec 18.


Relaxed purifying selection and possibly high rate of adaptation in primate lineage-specific genes.

Cai JJ, Petrov DA.

Genome Biol Evol. 2010 Jul 12;2:393-409. doi: 10.1093/gbe/evq019.


The relation between the neutrality index for mitochondrial genes and the distribution of mutational effects on fitness.

Betancourt AJ, Blanco-Martin B, Charlesworth B.

Evolution. 2012 Aug;66(8):2427-38. doi: 10.1111/j.1558-5646.2012.01628.x. Epub 2012 Apr 11.


The distribution of fitness effects of new mutations.

Eyre-Walker A, Keightley PD.

Nat Rev Genet. 2007 Aug;8(8):610-8. Review.


The deleterious mutation load is insensitive to recent population history.

Simons YB, Turchin MC, Pritchard JK, Sella G.

Nat Genet. 2014 Mar;46(3):220-4. doi: 10.1038/ng.2896. Epub 2014 Feb 9.


Positional conservation and amino acids shape the correct diagnosis and population frequencies of benign and damaging personal amino acid mutations.

Kumar S, Suleski MP, Markov GJ, Lawrence S, Marco A, Filipski AJ.

Genome Res. 2009 Sep;19(9):1562-9. doi: 10.1101/gr.091991.109. Epub 2009 Jun 22.


A general population genetic framework for antagonistic selection that accounts for demography and recurrent mutation.

Connallon T, Clark AG.

Genetics. 2012 Apr;190(4):1477-89. doi: 10.1534/genetics.111.137117. Epub 2012 Jan 31.


The amino-acid mutational spectrum of human genetic disease.

Vitkup D, Sander C, Church GM.

Genome Biol. 2003;4(11):R72. Epub 2003 Oct 30.


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