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Items: 1 to 20 of 77

1.

Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices.

Erxleben C, Liao Y, Gentile S, Chin D, Gomez-Alegria C, Mori Y, Birnbaumer L, Armstrong DL.

Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3932-7. Epub 2006 Feb 28.

2.

Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome.

Navedo MF, Cheng EP, Yuan C, Votaw S, Molkentin JD, Scott JD, Santana LF.

Circ Res. 2010 Mar 5;106(4):748-56. doi: 10.1161/CIRCRESAHA.109.213363. Epub 2010 Jan 28.

3.

Effect of the Brugada syndrome mutation A39V on calmodulin regulation of Cav1.2 channels.

Simms BA, Souza IA, Zamponi GW.

Mol Brain. 2014 Apr 28;7:34. doi: 10.1186/1756-6606-7-34.

4.

The Timothy syndrome mutation of cardiac CaV1.2 (L-type) channels: multiple altered gating mechanisms and pharmacological restoration of inactivation.

Yarotskyy V, Gao G, Peterson BZ, Elmslie KS.

J Physiol. 2009 Feb 1;587(3):551-65. doi: 10.1113/jphysiol.2008.161737. Epub 2008 Dec 15.

5.

CaMKII phosphorylates a threonine residue in the C-terminal tail of Cav1.2 Ca(2+) channel and modulates the interaction of the channel with calmodulin.

Wang WY, Hao LY, Minobe E, Saud ZA, Han DY, Kameyama M.

J Physiol Sci. 2009 Jul;59(4):283-90. doi: 10.1007/s12576-009-0033-y. Epub 2009 Mar 20.

PMID:
19340532
6.

Basal and β-adrenergic regulation of the cardiac calcium channel CaV1.2 requires phosphorylation of serine 1700.

Fu Y, Westenbroek RE, Scheuer T, Catterall WA.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16598-603. doi: 10.1073/pnas.1419129111. Epub 2014 Nov 3.

7.

Modulation of cardiac Ca(V)1.2 channels by dihydropyridine and phosphatase inhibitor requires Ser-1142 in the domain III pore loop.

Erxleben C, Gomez-Alegria C, Darden T, Mori Y, Birnbaumer L, Armstrong DL.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2929-34. Epub 2003 Feb 24.

8.

Cav1.4alpha1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation.

Koschak A, Reimer D, Walter D, Hoda JC, Heinzle T, Grabner M, Striessnig J.

J Neurosci. 2003 Jul 9;23(14):6041-9.

9.

Switching off calcium-dependent inactivation in L-type calcium channels by an autoinhibitory domain.

Wahl-Schott C, Baumann L, Cuny H, Eckert C, Griessmeier K, Biel M.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15657-62. Epub 2006 Oct 6.

10.

Roles of molecular regions in determining differences between voltage dependence of activation of CaV3.1 and CaV1.2 calcium channels.

Li J, Stevens L, Klugbauer N, Wray D.

J Biol Chem. 2004 Jun 25;279(26):26858-67. Epub 2004 Apr 20.

11.
12.

Impact of gating modulation in CaV1.3 L-type calcium channels.

Koschak A.

Channels (Austin). 2010 Nov-Dec;4(6):523-5. Epub 2010 Nov 1. Review.

13.

Negatively charged residues in the N-terminal of the AID helix confer slow voltage dependent inactivation gating to CaV1.2.

Dafi O, Berrou L, Dodier Y, Raybaud A, Sauvé R, Parent L.

Biophys J. 2004 Nov;87(5):3181-92. Epub 2004 Aug 31.

14.

Facilitation of murine cardiac L-type Ca(v)1.2 channel is modulated by calmodulin kinase II-dependent phosphorylation of S1512 and S1570.

Blaich A, Welling A, Fischer S, Wegener JW, Köstner K, Hofmann F, Moosmang S.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10285-9. doi: 10.1073/pnas.0914287107. Epub 2010 May 17.

15.

Impaired gating of an L-Type Ca(2+) channel carrying a mutation linked to malignant hyperthermia.

Bannister RA, Beam KG.

Biophys J. 2013 May 7;104(9):1917-22. doi: 10.1016/j.bpj.2013.03.035. Erratum in: Biophys J. 2015 May 5;108(9):2420.

16.

Timothy mutation disrupts the link between activation and inactivation in Ca(V)1.2 protein.

Depil K, Beyl S, Stary-Weinzinger A, Hohaus A, Timin E, Hering S.

J Biol Chem. 2011 Sep 9;286(36):31557-64. doi: 10.1074/jbc.M111.255273. Epub 2011 Jun 17.

18.

Hallmarks of the channelopathies associated with L-type calcium channels: a focus on the Timothy mutations in Ca(v)1.2 channels.

Bidaud I, Lory P.

Biochimie. 2011 Dec;93(12):2080-6. doi: 10.1016/j.biochi.2011.05.015. Epub 2011 May 31. Review.

PMID:
21664226
19.

Swapping the I-II intracellular linker between L-type CaV1.2 and R-type CaV2.3 high-voltage gated calcium channels exchanges activation attributes.

Gonzalez-Gutierrez G, Miranda-Laferte E, Contreras G, Neely A, Hidalgo P.

Channels (Austin). 2010 Jan-Feb;4(1):42-50. Epub 2010 Jan 9.

PMID:
20026913
20.

Cellular mechanisms of ventricular arrhythmias in a mouse model of Timothy syndrome (long QT syndrome 8).

Drum BM, Dixon RE, Yuan C, Cheng EP, Santana LF.

J Mol Cell Cardiol. 2014 Jan;66:63-71. doi: 10.1016/j.yjmcc.2013.10.021. Epub 2013 Nov 9.

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