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Items: 1 to 20 of 142

1.

Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation.

Swiatek W, Kang H, Garcia BA, Shabanowitz J, Coombs GS, Hunt DF, Virshup DM.

J Biol Chem. 2006 May 5;281(18):12233-41. Epub 2006 Mar 2.

2.

Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway.

Mi K, Johnson GV.

J Cell Biochem. 2005 May 15;95(2):328-38.

PMID:
15778991
3.

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.

Bourhis E, Tam C, Franke Y, Bazan JF, Ernst J, Hwang J, Costa M, Cochran AG, Hannoush RN.

J Biol Chem. 2010 Mar 19;285(12):9172-9. doi: 10.1074/jbc.M109.092130. Epub 2010 Jan 21.

4.

Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.

Nam JS, Turcotte TJ, Smith PF, Choi S, Yoon JK.

J Biol Chem. 2006 May 12;281(19):13247-57. Epub 2006 Mar 16.

5.

LRP6 mediates Wnt/β-catenin signaling and regulates adipogenic differentiation in human mesenchymal stem cells.

Peröbner I, Karow M, Jochum M, Neth P.

Int J Biochem Cell Biol. 2012 Nov;44(11):1970-82. doi: 10.1016/j.biocel.2012.07.025. Epub 2012 Aug 2.

PMID:
22871567
6.

Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation.

Ding Y, Xi Y, Chen T, Wang JY, Tao DL, Wu ZL, Li YP, Li C, Zeng R, Li L.

J Cell Biol. 2008 Sep 8;182(5):865-72. doi: 10.1083/jcb.200803147. Epub 2008 Sep 1.

7.

Regulation of casein kinase I epsilon activity by Wnt signaling.

Swiatek W, Tsai IC, Klimowski L, Pepler A, Barnette J, Yost HJ, Virshup DM.

J Biol Chem. 2004 Mar 26;279(13):13011-7. Epub 2004 Jan 13.

8.

CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila.

Klein TJ, Jenny A, Djiane A, Mlodzik M.

Curr Biol. 2006 Jul 11;16(13):1337-43.

9.

Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling.

Yamamoto H, Sakane H, Yamamoto H, Michiue T, Kikuchi A.

Dev Cell. 2008 Jul;15(1):37-48. doi: 10.1016/j.devcel.2008.04.015.

10.

The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling.

Schwarz-Romond T, Asbrand C, Bakkers J, Kühl M, Schaeffer HJ, Huelsken J, Behrens J, Hammerschmidt M, Birchmeier W.

Genes Dev. 2002 Aug 15;16(16):2073-84.

11.
12.

Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction.

Davidson G, Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A, Niehrs C.

Nature. 2005 Dec 8;438(7069):867-72.

PMID:
16341016
13.
14.

Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function.

Sakanaka C, Leong P, Xu L, Harrison SD, Williams LT.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12548-52.

15.

N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation.

Haÿ E, Laplantine E, Geoffroy V, Frain M, Kohler T, Müller R, Marie PJ.

Mol Cell Biol. 2009 Feb;29(4):953-64. doi: 10.1128/MCB.00349-08. Epub 2008 Dec 15.

16.

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies.

Ettenberg SA, Charlat O, Daley MP, Liu S, Vincent KJ, Stuart DD, Schuller AG, Yuan J, Ospina B, Green J, Yu Q, Walsh R, Li S, Schmitz R, Heine H, Bilic S, Ostrom L, Mosher R, Hartlepp KF, Zhu Z, Fawell S, Yao YM, Stover D, Finan PM, Porter JA, Sellers WR, Klagge IM, Cong F.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15473-8. doi: 10.1073/pnas.1007428107. Epub 2010 Aug 16.

17.

Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6.

Wu G, Huang H, Garcia Abreu J, He X.

PLoS One. 2009;4(3):e4926. doi: 10.1371/journal.pone.0004926. Epub 2009 Mar 18.

18.

Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation.

Tanneberger K, Pfister AS, Brauburger K, Schneikert J, Hadjihannas MV, Kriz V, Schulte G, Bryja V, Behrens J.

EMBO J. 2011 Apr 20;30(8):1433-43. doi: 10.1038/emboj.2011.28. Epub 2011 Feb 8.

19.

LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.

He X, Semenov M, Tamai K, Zeng X.

Development. 2004 Apr;131(8):1663-77. Review.

20.

A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression.

Jho Eh, Lomvardas S, Costantini F.

Biochem Biophys Res Commun. 1999 Dec 9;266(1):28-35.

PMID:
10581160

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