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Imaging studies and APOE genotype in persons at risk for Alzheimer's disease.

Scarmeas N, Stern Y.

Curr Psychiatry Rep. 2006 Feb;8(1):11-7. Review.


Altered PET functional brain responses in cognitively intact elderly persons at risk for Alzheimer disease (carriers of the epsilon4 allele).

Scarmeas N, Habeck C, Anderson KE, Hilton J, Devanand DP, Pelton GH, Tabert MH, Flynn J, Park A, Ciappa A, Tycko B, Stern Y.

Am J Geriatr Psychiatry. 2004 Nov-Dec;12(6):596-605.


Apolipoprotein E epsilon4 allele, temporal lobe atrophy, and white matter lesions in late-life dementias.

Barber R, Gholkar A, Scheltens P, Ballard C, McKeith IG, Morris CM, O'Brien JT.

Arch Neurol. 1999 Aug;56(8):961-5.


Reduced hippocampal volume in non-demented carriers of the apolipoprotein E epsilon4: relation to chronological age and recognition memory.

Lind J, Larsson A, Persson J, Ingvar M, Nilsson LG, Bäckman L, Adolfsson R, Cruts M, Sleegers K, Van Broeckhoven C, Nyberg L.

Neurosci Lett. 2006 Mar 20;396(1):23-7. Epub 2006 Jan 6.


Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease.

Wolk DA, Dickerson BC; Alzheimer's Disease Neuroimaging Initiative.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10256-61. doi: 10.1073/pnas.1001412107. Epub 2010 May 17.


Apolipoprotein E ε4 Modulates Cognitive Profiles, Hippocampal Volume, and Resting-State Functional Connectivity in Alzheimer's Disease.

Wang X, Wang J, He Y, Li H, Yuan H, Evans A, Yu X, He Y, Wang H.

J Alzheimers Dis. 2015;45(3):781-95. doi: 10.3233/JAD-142556.


Patterns of brain activation in people at risk for Alzheimer's disease.

Bookheimer SY, Strojwas MH, Cohen MS, Saunders AM, Pericak-Vance MA, Mazziotta JC, Small GW.

N Engl J Med. 2000 Aug 17;343(7):450-6.


Family history of Alzheimer's disease and hippocampal structure in healthy people.

Donix M, Burggren AC, Suthana NA, Siddarth P, Ekstrom AD, Krupa AK, Jones M, Martin-Harris L, Ercoli LM, Miller KJ, Small GW, Bookheimer SY.

Am J Psychiatry. 2010 Nov;167(11):1399-406. doi: 10.1176/appi.ajp.2010.09111575. Epub 2010 Aug 4.


Reduced functional brain activity response in cognitively intact apolipoprotein E epsilon4 carriers.

Lind J, Persson J, Ingvar M, Larsson A, Cruts M, Van Broeckhoven C, Adolfsson R, Bäckman L, Nilsson LG, Petersson KM, Nyberg L.

Brain. 2006 May;129(Pt 5):1240-8. Epub 2006 Mar 14.


Assessment of Alzheimer's disease risk with functional magnetic resonance imaging: an arterial spin labeling study.

Bangen KJ, Restom K, Liu TT, Wierenga CE, Jak AJ, Salmon DP, Bondi MW.

J Alzheimers Dis. 2012;31 Suppl 3:S59-74.


APOE genotype and hippocampal volume change in geriatric depression.

Kim DH, Payne ME, Levy RM, MacFall JR, Steffens DC.

Biol Psychiatry. 2002 Mar 1;51(5):426-9.


Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's disease: a cross-sectional study.

Trivedi MA, Schmitz TW, Ries ML, Torgerson BM, Sager MA, Hermann BP, Asthana S, Johnson SC.

BMC Med. 2006 Jan 13;4:1.


APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging.

Thambisetty M, Beason-Held L, An Y, Kraut MA, Resnick SM.

Arch Neurol. 2010 Jan;67(1):93-8. doi: 10.1001/archneurol.2009.913.


Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease.

Lautner R, Palmqvist S, Mattsson N, Andreasson U, Wallin A, Pålsson E, Jakobsson J, Herukka SK, Owenius R, Olsson B, Hampel H, Rujescu D, Ewers M, Landén M, Minthon L, Blennow K, Zetterberg H, Hansson O; Alzheimer’s Disease Neuroimaging Initiative.

JAMA Psychiatry. 2014 Oct;71(10):1183-91. doi: 10.1001/jamapsychiatry.2014.1060.


fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease.

Bondi MW, Houston WS, Eyler LT, Brown GG.

Neurology. 2005 Feb 8;64(3):501-8.


Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele.

Wishart HA, Saykin AJ, Rabin LA, Santulli RB, Flashman LA, Guerin SJ, Mamourian AC, Belloni DR, Rhodes CH, McAllister TW.

Am J Psychiatry. 2006 Sep;163(9):1603-10.


Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease.

Jack CR Jr, Petersen RC, Xu YC, O'Brien PC, Waring SC, Tangalos EG, Smith GE, Ivnik RJ, Thibodeau SN, Kokmen E.

Ann Neurol. 1998 Mar;43(3):303-10. Review.


Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study.

Liu Y, Paajanen T, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Proitsi P, Powell J, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H; AddNeuroMed Consortium.

J Alzheimers Dis. 2010;21(3):947-66. doi: 10.3233/JAD-2010-100201.


The effect of APOE epsilon4 allele on cerebral glucose metabolism in AD is a function of age at onset.

Hirono N, Hashimoto M, Yasuda M, Ishii K, Sakamoto S, Kazui H, Mori E.

Neurology. 2002 Mar 12;58(5):743-50.


Hypometabolism in Alzheimer-affected brain regions in cognitively healthy Latino individuals carrying the apolipoprotein E epsilon4 allele.

Langbaum JB, Chen K, Caselli RJ, Lee W, Reschke C, Bandy D, Alexander GE, Burns CM, Kaszniak AW, Reeder SA, Corneveaux JJ, Allen AN, Pruzin J, Huentelman MJ, Fleisher AS, Reiman EM.

Arch Neurol. 2010 Apr;67(4):462-8. doi: 10.1001/archneurol.2010.30.

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