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Fibroblast activation protein (FAP) is upregulated in myelomatous bone and supports myeloma cell survival.

Ge Y, Zhan F, Barlogie B, Epstein J, Shaughnessy J Jr, Yaccoby S.

Br J Haematol. 2006 Apr;133(1):83-92.


Clinical implications of fibroblast activation protein in patients with colon cancer.

Henry LR, Lee HO, Lee JS, Klein-Szanto A, Watts P, Ross EA, Chen WT, Cheng JD.

Clin Cancer Res. 2007 Mar 15;13(6):1736-41.


Gene expression profiling of bone marrow endothelial cells in patients with multiple myeloma.

Ria R, Todoerti K, Berardi S, Coluccia AM, De Luisi A, Mattioli M, Ronchetti D, Morabito F, Guarini A, Petrucci MT, Dammacco F, Ribatti D, Neri A, Vacca A.

Clin Cancer Res. 2009 Sep 1;15(17):5369-78. doi: 10.1158/1078-0432.CCR-09-0040. Epub 2009 Aug 18.


Inhibitor of DASH proteases affects expression of adhesion molecules in osteoclasts and reduces myeloma growth and bone disease.

Pennisi A, Li X, Ling W, Khan S, Gaddy D, Suva LJ, Barlogie B, Shaughnessy JD, Aziz N, Yaccoby S.

Br J Haematol. 2009 Jun;145(6):775-87. doi: 10.1111/j.1365-2141.2009.07696.x. Epub 2009 Apr 8.


Characterization of in vitro growth of multiple myeloma cells.

Zlei M, Egert S, Wider D, Ihorst G, Wäsch R, Engelhardt M.

Exp Hematol. 2007 Oct;35(10):1550-61.


Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption: a role for vascular endothelial cell growth factor and osteopontin.

Tanaka Y, Abe M, Hiasa M, Oda A, Amou H, Nakano A, Takeuchi K, Kitazoe K, Kido S, Inoue D, Moriyama K, Hashimoto T, Ozaki S, Matsumoto T.

Clin Cancer Res. 2007 Feb 1;13(3):816-23.


Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers.

Scanlan MJ, Raj BK, Calvo B, Garin-Chesa P, Sanz-Moncasi MP, Healey JH, Old LJ, Rettig WJ.

Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5657-61.


Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions.

Huang Y, Simms AE, Mazur A, Wang S, León NR, Jones B, Aziz N, Kelly T.

Clin Exp Metastasis. 2011 Aug;28(6):567-79. doi: 10.1007/s10585-011-9392-x. Epub 2011 May 22.


Species-crossreactive scFv against the tumor stroma marker "fibroblast activation protein" selected by phage display from an immunized FAP-/- knock-out mouse.

Brocks B, Garin-Chesa P, Behrle E, Park JE, Rettig WJ, Pfizenmaier K, Moosmayer D.

Mol Med. 2001 Jul;7(7):461-9.


Expression of stromal cell markers in distinct compartments of human skin cancers.

Huber MA, Kraut N, Schweifer N, Dolznig H, Peter RU, Schubert RD, Scharffetter-Kochanek K, Pehamberger H, Garin-Chesa P.

J Cutan Pathol. 2006 Feb;33(2):145-55.


Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin.

Dolznig H, Schweifer N, Puri C, Kraut N, Rettig WJ, Kerjaschki D, Garin-Chesa P.

Cancer Immun. 2005 Aug 3;5:10.


Fibroblast activation protein regulates tumor-associated fibroblasts and epithelial ovarian cancer cells.

Lai D, Ma L, Wang F.

Int J Oncol. 2012 Aug;41(2):541-50. doi: 10.3892/ijo.2012.1475. Epub 2012 May 14.


Fibroblast activation protein protects bortezomib-induced apoptosis in multiple myeloma cells through β-catenin signaling pathway.

Zi FM, He JS, Li Y, Wu C, Wu WJ, Yang Y, Wang LJ, He DH, Yang L, Zhao Y, Zheng GF, Han XY, Huang H, Yi Q, Cai Z.

Cancer Biol Ther. 2014 Oct;15(10):1413-22. doi: 10.4161/cbt.29924. Epub 2014 Jul 21.


Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts.

Park JE, Lenter MC, Zimmermann RN, Garin-Chesa P, Old LJ, Rettig WJ.

J Biol Chem. 1999 Dec 17;274(51):36505-12.


Number of expressed cancer/testis antigens identifies focal adhesion pathway genes as possible targets for multiple myeloma therapy.

Andrade VC, Vettore AL, Panepucci RA, Almeida MS, Yamamoto M, De Carvalho F, Caballero OL, Zago MA, Colleoni GW.

Leuk Lymphoma. 2010 Aug;51(8):1543-9. doi: 10.3109/10428194.2010.491136.


Promotion of tumor growth by murine fibroblast activation protein, a serine protease, in an animal model.

Cheng JD, Dunbrack RL Jr, Valianou M, Rogatko A, Alpaugh RK, Weiner LM.

Cancer Res. 2002 Aug 15;62(16):4767-72.


Migration, adhesion and differentiation of malignant plasma cells in the 5T murine model of myeloma.

Asosingh K.

Verh K Acad Geneeskd Belg. 2003;65(2):127-34. Review.


Expression and targeting of human fibroblast activation protein in a human skin/severe combined immunodeficient mouse breast cancer xenograft model.

Tahtis K, Lee FT, Wheatley JM, Garin-Chesa P, Park JE, Smyth FE, Obata Y, Stockert E, Hall CM, Old LJ, Rettig WJ, Scott AM.

Mol Cancer Ther. 2003 Aug;2(8):729-37.


Single-chain Fv immunoliposomes for the targeting of fibroblast activation protein-expressing tumor stromal cells.

Baum P, Müller D, Rüger R, Kontermann RE.

J Drug Target. 2007 Jul;15(6):399-406.


Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line.

Wang XM, Yu DM, McCaughan GW, Gorrell MD.

Hepatology. 2005 Oct;42(4):935-45.


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