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Items: 1 to 20 of 159

1.

BRCA1 DNA-binding activity is stimulated by BARD1.

Simons AM, Horwitz AA, Starita LM, Griffin K, Williams RS, Glover JN, Parvin JD.

Cancer Res. 2006 Feb 15;66(4):2012-8.

2.

Structural requirements for the BARD1 tumor suppressor in chromosomal stability and homology-directed DNA repair.

Laufer M, Nandula SV, Modi AP, Wang S, Jasin M, Murty VV, Ludwig T, Baer R.

J Biol Chem. 2007 Nov 23;282(47):34325-33. Epub 2007 Sep 11.

3.

BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity.

Nishikawa H, Wu W, Koike A, Kojima R, Gomi H, Fukuda M, Ohta T.

Cancer Res. 2009 Jan 1;69(1):111-9. doi: 10.1158/0008-5472.CAN-08-3355.

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6.

The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function.

Wu-Baer F, Ludwig T, Baer R.

Mol Cell Biol. 2010 Jun;30(11):2787-98. doi: 10.1128/MCB.01056-09. Epub 2010 Mar 29.

7.

Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase.

Chen A, Kleiman FE, Manley JL, Ouchi T, Pan ZQ.

J Biol Chem. 2002 Jun 14;277(24):22085-92. Epub 2002 Apr 1.

8.

Negative feedback loop of BRCA1-BARD1 ubiquitin ligase on estrogen receptor alpha stability and activity antagonized by cancer-associated isoform of BARD1.

Dizin E, Irminger-Finger I.

Int J Biochem Cell Biol. 2010 May;42(5):693-700. doi: 10.1016/j.biocel.2009.12.025. Epub 2010 Jan 11.

PMID:
20060929
9.

BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II.

Starita LM, Horwitz AA, Keogh MC, Ishioka C, Parvin JD, Chiba N.

J Biol Chem. 2005 Jul 1;280(26):24498-505. Epub 2005 May 10.

10.

Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2.

Hayami R, Sato K, Wu W, Nishikawa T, Hiroi J, Ohtani-Kaneko R, Fukuda M, Ohta T.

Cancer Res. 2005 Jan 1;65(1):6-10.

11.

BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention.

Fabbro M, Schuechner S, Au WW, Henderson BR.

Exp Cell Res. 2004 Aug 15;298(2):661-73.

PMID:
15265711
12.

Nuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1.

Rodriguez JA, Schüchner S, Au WW, Fabbro M, Henderson BR.

Oncogene. 2004 Mar 11;23(10):1809-20.

PMID:
14647430
13.

Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase.

Nishikawa H, Ooka S, Sato K, Arima K, Okamoto J, Klevit RE, Fukuda M, Ohta T.

J Biol Chem. 2004 Feb 6;279(6):3916-24. Epub 2003 Nov 24.

14.

The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly.

Joukov V, Groen AC, Prokhorova T, Gerson R, White E, Rodriguez A, Walter JC, Livingston DM.

Cell. 2006 Nov 3;127(3):539-52.

15.

Characterization of BARD1 targeting and dynamics at the centrosome: the role of CRM1, BRCA1 and the Q564H mutation.

Brodie KM, Mok MT, Henderson BR.

Cell Signal. 2012 Feb;24(2):451-9. doi: 10.1016/j.cellsig.2011.09.024. Epub 2011 Oct 1.

PMID:
21982881
16.

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.

Shakya R, Szabolcs M, McCarthy E, Ospina E, Basso K, Nandula S, Murty V, Baer R, Ludwig T.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):7040-5. doi: 10.1073/pnas.0711032105. Epub 2008 Apr 28.

17.

BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.

Fabbro M, Savage K, Hobson K, Deans AJ, Powell SN, McArthur GA, Khanna KK.

J Biol Chem. 2004 Jul 23;279(30):31251-8. Epub 2004 May 24.

18.

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by the platinum-based anticancer drugs.

Atipairin A, Canyuk B, Ratanaphan A.

Breast Cancer Res Treat. 2011 Feb;126(1):203-9. doi: 10.1007/s10549-010-1182-7. Epub 2010 Sep 29.

PMID:
20878461
19.

The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin.

Wu-Baer F, Lagrazon K, Yuan W, Baer R.

J Biol Chem. 2003 Sep 12;278(37):34743-6. Epub 2003 Jul 30.

20.

Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility.

Morris JR, Pangon L, Boutell C, Katagiri T, Keep NH, Solomon E.

Hum Mol Genet. 2006 Feb 15;15(4):599-606. Epub 2006 Jan 10.

PMID:
16403807

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