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Items: 1 to 20 of 86

1.

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

Bivona TG, Quatela SE, Bodemann BO, Ahearn IM, Soskis MJ, Mor A, Miura J, Wiener HH, Wright L, Saba SG, Yim D, Fein A, Pérez de Castro I, Li C, Thompson CB, Cox AD, Philips MR.

Mol Cell. 2006 Feb 17;21(4):481-93.

2.

The odyssey of k-ras.

Feig LA.

Mol Cell. 2006 Feb 17;21(4):447-9.

3.

Phosphorylated K-Ras limits cell survival by blocking Bcl-xL sensitization of inositol trisphosphate receptors.

Sung PJ, Tsai FD, Vais H, Court H, Yang J, Fehrenbacher N, Foskett JK, Philips MR.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20593-8. doi: 10.1073/pnas.1306431110. Epub 2013 Dec 2.

4.

Analysis of K-Ras phosphorylation, translocation, and induction of apoptosis.

Quatela SE, Sung PJ, Ahearn IM, Bivona TG, Philips MR.

Methods Enzymol. 2008;439:87-102. doi: 10.1016/S0076-6879(07)00407-7.

PMID:
18374158
5.

Novel extranuclear-targeted anthracyclines override the antiapoptotic functions of Bcl-2 and target protein kinase C pathways to induce apoptosis.

Barrett CM, Lewis FL, Roaten JB, Sweatman TW, Israel M, Cleveland JL, Lothstein L.

Mol Cancer Ther. 2002 May;1(7):469-81.

6.
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8.

p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway.

Tan Y, Ruan H, Demeter MR, Comb MJ.

J Biol Chem. 1999 Dec 3;274(49):34859-67.

9.

Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis.

May WS, Tyler PG, Ito T, Armstrong DK, Qatsha KA, Davidson NE.

J Biol Chem. 1994 Oct 28;269(43):26865-70.

10.

Specific modulation of apoptosis and Bcl-xL phosphorylation in yeast by distinct mammalian protein kinase C isoforms.

Saraiva L, Silva RD, Pereira G, Gonçalves J, Côrte-Real M.

J Cell Sci. 2006 Aug 1;119(Pt 15):3171-81. Epub 2006 Jul 11.

11.

Nonconventional trafficking of Ras associated with Ras signal organization.

Ashery U, Yizhar O, Rotblat B, Kloog Y.

Traffic. 2006 Sep;7(9):119-26. Review.

12.

A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells.

Sakurai T, Itoh K, Higashitsuji H, Nagao T, Nonoguchi K, Chiba T, Fujita J.

J Biol Chem. 2004 Apr 9;279(15):15505-14. Epub 2004 Jan 22.

13.

Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL.

Del Re DP, Matsuda T, Zhai P, Maejima Y, Jain MR, Liu T, Li H, Hsu CP, Sadoshima J.

Mol Cell. 2014 May 22;54(4):639-50. doi: 10.1016/j.molcel.2014.04.007. Epub 2014 May 8.

14.

Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability.

Imazu T, Shimizu S, Tagami S, Matsushima M, Nakamura Y, Miki T, Okuyama A, Tsujimoto Y.

Oncogene. 1999 Aug 12;18(32):4523-9.

15.

Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL.

Manicassamy S, Gupta S, Huang Z, Sun Z.

J Immunol. 2006 Jun 1;176(11):6709-16.

16.

Oncogenic K-ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status.

Barceló C, Paco N, Beckett AJ, Alvarez-Moya B, Garrido E, Gelabert M, Tebar F, Jaumot M, Prior I, Agell N.

J Cell Sci. 2013 Oct 15;126(Pt 20):4553-9. doi: 10.1242/jcs.123737. Epub 2013 Aug 13.

17.

Constitutive association of c-N-Ras with c-Raf-1 and protein kinase C epsilon in latent signaling modules.

Hamilton M, Liao J, Cathcart MK, Wolfman A.

J Biol Chem. 2001 Aug 3;276(31):29079-90. Epub 2001 May 17.

18.

K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and function.

Alvarez-Moya B, López-Alcalá C, Drosten M, Bachs O, Agell N.

Oncogene. 2010 Nov 4;29(44):5911-22. doi: 10.1038/onc.2010.298. Epub 2010 Aug 30.

PMID:
20802526
19.

Lovastatin induces apoptosis of k-ras-transformed thyroid cells via inhibition of ras farnesylation and by modulating redox state.

Laezza C, Fiorentino L, Pisanti S, Gazzerro P, Caraglia M, Portella G, Vitale M, Bifulco M.

J Mol Med (Berl). 2008 Dec;86(12):1341-51. doi: 10.1007/s00109-008-0396-1. Epub 2008 Sep 9.

PMID:
18779944
20.

Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-alpha.

Dlugosz AA, Cheng C, Williams EK, Dharia AG, Denning MF, Yuspa SH.

Cancer Res. 1994 Dec 15;54(24):6413-20.

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