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Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways.

Ravid T, Kreft SG, Hochstrasser M.

EMBO J. 2006 Feb 8;25(3):533-43. Epub 2006 Jan 26.


A Conserved C-terminal Element in the Yeast Doa10 and Human MARCH6 Ubiquitin Ligases Required for Selective Substrate Degradation.

Zattas D, Berk JM, Kreft SG, Hochstrasser M.

J Biol Chem. 2016 Jun 3;291(23):12105-18. doi: 10.1074/jbc.M116.726877. Epub 2016 Apr 11.


An unusual transmembrane helix in the endoplasmic reticulum ubiquitin ligase Doa10 modulates degradation of its cognate E2 enzyme.

Kreft SG, Hochstrasser M.

J Biol Chem. 2011 Jun 10;286(23):20163-74. doi: 10.1074/jbc.M110.196360. Epub 2011 Apr 5.


Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase.

Deng M, Hochstrasser M.

Nature. 2006 Oct 19;443(7113):827-31.


The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degron.

Habeck G, Ebner FA, Shimada-Kreft H, Kreft SG.

J Cell Biol. 2015 Apr 27;209(2):261-73. doi: 10.1083/jcb.201408088. Erratum in: J Cell Biol. 2015 May 25;209(4):621. J Cell Biol. 2015 Apr 27;209(2):260.


Dfm1 forms distinct complexes with Cdc48 and the ER ubiquitin ligases and is required for ERAD.

Stolz A, Schweizer RS, Schäfer A, Wolf DH.

Traffic. 2010 Oct;11(10):1363-9. doi: 10.1111/j.1600-0854.2010.01093.x.


Endoplasmic reticulum-associated degradation is required for cold adaptation and regulation of sterol biosynthesis in the yeast Saccharomyces cerevisiae.

Loertscher J, Larson LL, Matson CK, Parrish ML, Felthauser A, Sturm A, Tachibana C, Bard M, Wright R.

Eukaryot Cell. 2006 Apr;5(4):712-22.


Atypical ubiquitylation in yeast targets lysine-less Asi2 for proteasomal degradation.

Boban M, Ljungdahl PO, Foisner R.

J Biol Chem. 2015 Jan 23;290(4):2489-95. doi: 10.1074/jbc.M114.600593. Epub 2014 Dec 9.


N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates.

Zattas D, Adle DJ, Rubenstein EM, Hochstrasser M.

Mol Biol Cell. 2013 Apr;24(7):890-900. doi: 10.1091/mbc.E12-11-0838. Epub 2013 Jan 30.


Rkr1/Ltn1 Ubiquitin Ligase-mediated Degradation of Translationally Stalled Endoplasmic Reticulum Proteins.

Crowder JJ, Geigges M, Gibson RT, Fults ES, Buchanan BW, Sachs N, Schink A, Kreft SG, Rubenstein EM.

J Biol Chem. 2015 Jul 24;290(30):18454-66. doi: 10.1074/jbc.M115.663559. Epub 2015 Jun 8.


Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation.

Stolz A, Besser S, Hottmann H, Wolf DH.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15271-6. doi: 10.1073/pnas.1304928110. Epub 2013 Aug 29.


Ubx2 links the Cdc48 complex to ER-associated protein degradation.

Neuber O, Jarosch E, Volkwein C, Walter J, Sommer T.

Nat Cell Biol. 2005 Oct;7(10):993-8. Epub 2005 Sep 18.


Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation.

Kohlmann S, Schäfer A, Wolf DH.

J Biol Chem. 2008 Jun 13;283(24):16374-83. doi: 10.1074/jbc.M801702200. Epub 2008 Apr 24.


Distinct activation of an E2 ubiquitin-conjugating enzyme by its cognate E3 ligases.

Cohen I, Wiener R, Reiss Y, Ravid T.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E625-32. doi: 10.1073/pnas.1415621112. Epub 2015 Feb 2.


Protein quality control at the inner nuclear membrane.

Khmelinskii A, Blaszczak E, Pantazopoulou M, Fischer B, Omnus DJ, Le Dez G, Brossard A, Gunnarsson A, Barry JD, Meurer M, Kirrmaier D, Boone C, Huber W, Rabut G, Ljungdahl PO, Knop M.

Nature. 2014 Dec 18;516(7531):410-3. doi: 10.1038/nature14096.


Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligase.

Guerriero CJ, Weiberth KF, Brodsky JL.

J Biol Chem. 2013 Jun 21;288(25):18506-20. doi: 10.1074/jbc.M113.475905. Epub 2013 May 7.


Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase.

Rubenstein EM, Kreft SG, Greenblatt W, Swanson R, Hochstrasser M.

J Cell Biol. 2012 Jun 11;197(6):761-73. doi: 10.1083/jcb.201203061.

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