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Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb.

Blazek D, Barboric M, Kohoutek J, Oven I, Peterlin BM.

Nucleic Acids Res. 2005 Dec 23;33(22):7000-10.


Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.

Michels AA, Fraldi A, Li Q, Adamson TE, Bonnet F, Nguyen VT, Sedore SC, Price JP, Price DH, Lania L, Bensaude O.

EMBO J. 2004 Jul 7;23(13):2608-19.


Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb.

Barboric M, Kohoutek J, Price JP, Blazek D, Price DH, Peterlin BM.

EMBO J. 2005 Dec 21;24(24):4291-303.


Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA.

Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q.

Mol Cell. 2003 Oct;12(4):971-82.


Phosphorylation of HEXIM1 at Tyr271 and Tyr274 Promotes Release of P-TEFb from the 7SK snRNP Complex and Enhances Proviral HIV Gene Expression.

Mbonye UR, Wang B, Gokulrangan G, Chance MR, Karn J.

Proteomics. 2015 Jun;15(12):2078-86. doi: 10.1002/pmic.201500038. Erratum in: Proteomics. 2016 Aug;16(15-16):2302.


Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat.

Muniz L, Egloff S, Ughy B, Jády BE, Kiss T.

PLoS Pathog. 2010 Oct 14;6(10):e1001152. doi: 10.1371/journal.ppat.1001152.


PKC phosphorylates HEXIM1 and regulates P-TEFb activity.

Fujinaga K, Barboric M, Li Q, Luo Z, Price DH, Peterlin BM.

Nucleic Acids Res. 2012 Oct;40(18):9160-70. doi: 10.1093/nar/gks682.


Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.

Liu P, Xiang Y, Fujinaga K, Bartholomeeusen K, Nilson KA, Price DH, Peterlin BM.

J Biol Chem. 2014 Apr 4;289(14):9918-25. doi: 10.1074/jbc.M113.539015.


RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP.

Muniz L, Egloff S, Kiss T.

Nucleic Acids Res. 2013 Apr;41(8):4686-98. doi: 10.1093/nar/gkt159.


Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR.

Sedore SC, Byers SA, Biglione S, Price JP, Maury WJ, Price DH.

Nucleic Acids Res. 2007;35(13):4347-58.


Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA.

Czudnochowski N, Vollmuth F, Baumann S, Vogel-Bachmayr K, Geyer M.

J Mol Biol. 2010 Jan 8;395(1):28-41. doi: 10.1016/j.jmb.2009.10.055.


HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK.

Byers SA, Price JP, Cooper JJ, Li Q, Price DH.

J Biol Chem. 2005 Apr 22;280(16):16360-7.


Dynamic remodelling of human 7SK snRNP controls the nuclear level of active P-TEFb.

Van Herreweghe E, Egloff S, Goiffon I, Jády BE, Froment C, Monsarrat B, Kiss T.

EMBO J. 2007 Aug 8;26(15):3570-80.


The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK.

Krueger BJ, Varzavand K, Cooper JJ, Price DH.

PLoS One. 2010 Aug 23;5(8):e12335. doi: 10.1371/journal.pone.0012335.

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