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Items: 1 to 20 of 443

1.

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death.

Bjørkøy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T.

J Cell Biol. 2005 Nov 21;171(4):603-14. Epub 2005 Nov 14.

2.

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.

Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Øvervatn A, Bjørkøy G, Johansen T.

J Biol Chem. 2007 Aug 17;282(33):24131-45. Epub 2007 Jun 19.

3.

The evolutionarily conserved interaction between LC3 and p62 selectively mediates autophagy-dependent degradation of mutant huntingtin.

Tung YT, Hsu WM, Lee H, Huang WP, Liao YF.

Cell Mol Neurobiol. 2010 Jul;30(5):795-806. doi: 10.1007/s10571-010-9507-y. Epub 2010 Mar 5.

PMID:
20204693
4.

Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.

Matsumoto G, Wada K, Okuno M, Kurosawa M, Nukina N.

Mol Cell. 2011 Oct 21;44(2):279-89. doi: 10.1016/j.molcel.2011.07.039.

5.

Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation.

Fujita K, Maeda D, Xiao Q, Srinivasula SM.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1427-32. doi: 10.1073/pnas.1014156108. Epub 2011 Jan 10.

6.

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both.

Narendra D, Kane LA, Hauser DN, Fearnley IM, Youle RJ.

Autophagy. 2010 Nov;6(8):1090-106.

7.

The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway.

Zheng YT, Shahnazari S, Brech A, Lamark T, Johansen T, Brumell JH.

J Immunol. 2009 Nov 1;183(9):5909-16. doi: 10.4049/jimmunol.0900441. Epub 2009 Oct 7.

8.
9.

Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding.

Cha-Molstad H, Sung KS, Hwang J, Kim KA, Yu JE, Yoo YD, Jang JM, Han DH, Molstad M, Kim JG, Lee YJ, Zakrzewska A, Kim SH, Kim ST, Kim SY, Lee HG, Soung NK, Ahn JS, Ciechanover A, Kim BY, Kwon YT.

Nat Cell Biol. 2015 Jul;17(7):917-29. doi: 10.1038/ncb3177. Epub 2015 Jun 15.

10.

Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis.

Sergin I, Bhattacharya S, Emanuel R, Esen E, Stokes CJ, Evans TD, Arif B, Curci JA, Razani B.

Sci Signal. 2016 Jan 5;9(409):ra2. doi: 10.1126/scisignal.aad5614.

11.

p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells.

Viiri J, Hyttinen JM, Ryhänen T, Rilla K, Paimela T, Kuusisto E, Siitonen A, Urtti A, Salminen A, Kaarniranta K.

Mol Vis. 2010 Jul 27;16:1399-414.

12.

Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates.

Lim J, Lachenmayer ML, Wu S, Liu W, Kundu M, Wang R, Komatsu M, Oh YJ, Zhao Y, Yue Z.

PLoS Genet. 2015 Feb 27;11(2):e1004987. doi: 10.1371/journal.pgen.1004987. eCollection 2015.

13.

The selective autophagy receptor p62 forms a flexible filamentous helical scaffold.

Ciuffa R, Lamark T, Tarafder AK, Guesdon A, Rybina S, Hagen WJ, Johansen T, Sachse C.

Cell Rep. 2015 May 5;11(5):748-58. doi: 10.1016/j.celrep.2015.03.062. Epub 2015 Apr 23.

14.

Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury.

Sarkar C, Zhao Z, Aungst S, Sabirzhanov B, Faden AI, Lipinski MM.

Autophagy. 2014;10(12):2208-22. doi: 10.4161/15548627.2014.981787.

15.

Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy.

Fan W, Tang Z, Chen D, Moughon D, Ding X, Chen S, Zhu M, Zhong Q.

Autophagy. 2010 Jul;6(5):614-21. doi: 10.4161/auto.6.5.12189. Epub 2010 Jul 1.

16.

Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1.

Svenning S, Lamark T, Krause K, Johansen T.

Autophagy. 2011 Sep;7(9):993-1010. Epub 2011 Sep 1.

17.

Depletion of the ubiquitin-binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr ΔF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery.

Abdulrahman BA, Khweek AA, Akhter A, Caution K, Tazi M, Hassan H, Zhang Y, Rowland PD, Malhotra S, Aeffner F, Davis IC, Valvano MA, Amer AO.

J Biol Chem. 2013 Jan 18;288(3):2049-58. doi: 10.1074/jbc.M112.411728. Epub 2012 Nov 12.

18.

Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism.

Gal J, Ström AL, Kwinter DM, Kilty R, Zhang J, Shi P, Fu W, Wooten MW, Zhu H.

J Neurochem. 2009 Nov;111(4):1062-73. doi: 10.1111/j.1471-4159.2009.06388.x. Epub 2009 Sep 18.

19.

Autophagic flux determines cell death and survival in response to Apo2L/TRAIL (dulanermin).

Singh K, Sharma A, Mir MC, Drazba JA, Heston WD, Magi-Galluzzi C, Hansel D, Rubin BP, Klein EA, Almasan A.

Mol Cancer. 2014 Mar 23;13:70. doi: 10.1186/1476-4598-13-70.

20.

p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways.

Christian F, Anthony DF, Vadrevu S, Riddell T, Day JP, McLeod R, Adams DR, Baillie GS, Houslay MD.

Cell Signal. 2010 Oct;22(10):1576-96. doi: 10.1016/j.cellsig.2010.06.003. Epub 2010 Jun 19.

PMID:
20600853

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