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Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia.

Maddux BA, Chang YN, Accili D, McGuinness OP, Youngren JF, Goldfine ID.

Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E746-9. Epub 2005 Nov 8.


Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance.

Dong H, Maddux BA, Altomonte J, Meseck M, Accili D, Terkeltaub R, Johnson K, Youngren JF, Goldfine ID.

Diabetes. 2005 Feb;54(2):367-72.


Metabolic consequences of ENPP1 overexpression in adipose tissue.

Pan W, Ciociola E, Saraf M, Tumurbaatar B, Tuvdendorj D, Prasad S, Chandalia M, Abate N.

Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E901-11. doi: 10.1152/ajpendo.00087.2011. Epub 2011 Aug 2.


No correlation of plasma cell 1 overexpression with insulin resistance in diabetic rats and 3T3-L1 adipocytes.

Sakoda H, Ogihara T, Anai M, Funaki M, Inukai K, Katagiri H, Fukushima Y, Onishi Y, Ono H, Yazaki Y, Kikuchi M, Oka Y, Asano T.

Diabetes. 1999 Jul;48(7):1365-71.


Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo.

Zhou HH, Chin CN, Wu M, Ni W, Quan S, Liu F, Dallas-Yang Q, Ellsworth K, Ho T, Zhang A, Natasha T, Li J, Chapman K, Strohl W, Li C, Wang IM, Berger J, An Z, Zhang BB, Jiang G.

Eur J Pharmacol. 2009 Aug 15;616(1-3):346-52. doi: 10.1016/j.ejphar.2009.06.057. Epub 2009 Jul 3.


Elevated plasma cell membrane glycoprotein levels and diminished insulin receptor autophosphorylation in obese, insulin-resistant rhesus monkeys.

Pender C, Ortmeyer HK, Hansen BC, Goldfine ID, Youngren JF.

Metabolism. 2002 Apr;51(4):465-70.


A cluster of three single nucleotide polymorphisms in the 3'-untranslated region of human glycoprotein PC-1 gene stabilizes PC-1 mRNA and is associated with increased PC-1 protein content and insulin resistance-related abnormalities.

Frittitta L, Ercolino T, Bozzali M, Argiolas A, Graci S, Santagati MG, Spampinato D, Di Paola R, Cisternino C, Tassi V, Vigneri R, Pizzuti A, Trischitta V.

Diabetes. 2001 Aug;50(8):1952-5.


The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities.

Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L.

Endocr Rev. 2008 Feb;29(1):62-75. doi: 10.1210/er.2007-0004. Epub 2008 Jan 16. Review. Erratum in: Endocr Rev. 2009 Feb;30(1):117.


Rats that are made insulin resistant by glucosamine treatment have impaired skeletal muscle insulin receptor phosphorylation.

Spampinato D, Giaccari A, Trischitta V, Costanzo BV, Morviducci L, Buongiorno A, Di Mario U, Vigneri R, Frittitta L.

Metabolism. 2003 Sep;52(9):1092-5.


Adipose tissue dysfunction in humans: a potential role for the transmembrane protein ENPP1.

Chandalia M, Davila H, Pan W, Szuszkiewicz M, Tuvdendorj D, Livingston EH, Abate N.

J Clin Endocrinol Metab. 2012 Dec;97(12):4663-72. doi: 10.1210/jc.2012-2018. Epub 2012 Sep 25.


Skeletal muscle content of membrane glycoprotein PC-1 in obesity. Relationship to muscle glucose transport.

Youngren JF, Maddux BA, Sasson S, Sbraccia P, Tapscott EB, Swanson MS, Dohm GL, Goldfine ID.

Diabetes. 1996 Oct;45(10):1324-8.


Role of PC-1 in the etiology of insulin resistance.

Goldfine ID, Maddux BA, Youngren JF, Trischitta V, Frittitta L.

Ann N Y Acad Sci. 1999 Nov 18;892:204-22. Review.


Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle.

Carvalho E, Kotani K, Peroni OD, Kahn BB.

Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E551-61. Epub 2005 May 31.


Regulation of glycogen synthase activity in cultured skeletal muscle cells from subjects with type II diabetes: role of chronic hyperinsulinemia and hyperglycemia.

Nikoulina SE, Ciaraldi TP, Abrams-Carter L, Mudaliar S, Park KS, Henry RR.

Diabetes. 1997 Jun;46(6):1017-24.


Hypoglycemic effects and mechanisms of electroacupuncture on insulin resistance.

Yin J, Kuang J, Chandalia M, Tuvdendorj D, Tumurbaatar B, Abate N, Chen JD.

Am J Physiol Regul Integr Comp Physiol. 2014 Aug 1;307(3):R332-9. doi: 10.1152/ajpregu.00465.2013. Epub 2014 May 21.


ENPP1 affects insulin action and secretion: evidences from in vitro studies.

Di Paola R, Caporarello N, Marucci A, Dimatteo C, Iadicicco C, Del Guerra S, Prudente S, Sudano D, Miele C, Parrino C, Piro S, Beguinot F, Marchetti P, Trischitta V, Frittitta L.

PLoS One. 2011 May 5;6(5):e19462. doi: 10.1371/journal.pone.0019462.


Liver ENPP1 protein increases with remission of type 2 diabetes after gastric bypass surgery.

Besic V, Stubbs RS, Hayes MT.

BMC Gastroenterol. 2014 Dec 24;14:222. doi: 10.1186/s12876-014-0222-x.


Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling.

Hong EG, Jung DY, Ko HJ, Zhang Z, Ma Z, Jun JY, Kim JH, Sumner AD, Vary TC, Gardner TW, Bronson SK, Kim JK.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1687-96. Epub 2007 Oct 2.


PANDER transgenic mice display fasting hyperglycemia and hepatic insulin resistance.

Robert-Cooperman CE, Dougan GC, Moak SL, Athanason MG, Kuehl MN, Bell-Temin H, Stevens SM Jr, Burkhardt BR.

J Endocrinol. 2014 Jan 27;220(3):219-31. doi: 10.1530/JOE-13-0338. Print 2014 Mar.

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