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Items: 1 to 20 of 121

1.
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p21-activated kinase links Rac/Cdc42 signaling to merlin.

Xiao GH, Beeser A, Chernoff J, Testa JR.

J Biol Chem. 2002 Jan 11;277(2):883-6. Epub 2001 Nov 21.

4.

PAK kinase regulates Rac GTPase and is a potential target in human schwannomas.

Flaiz C, Chernoff J, Ammoun S, Peterson JR, Hanemann CO.

Exp Neurol. 2009 Jul;218(1):137-44. doi: 10.1016/j.expneurol.2009.04.019. Epub 2009 May 3.

5.

Inactivation of the NF2 tumor suppressor protein merlin in DU145 prostate cancer cells.

Horiguchi A, Zheng R, Shen R, Nanus DM.

Prostate. 2008 Jun 15;68(9):975-84. doi: 10.1002/pros.20760.

PMID:
18361411
6.

The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression.

Xiao GH, Gallagher R, Shetler J, Skele K, Altomare DA, Pestell RG, Jhanwar S, Testa JR.

Mol Cell Biol. 2005 Mar;25(6):2384-94.

7.

Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration.

Dise RS, Frey MR, Whitehead RH, Polk DB.

Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G276-85. Epub 2007 Nov 8.

8.

The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP.

Striedinger K, VandenBerg SR, Baia GS, McDermott MW, Gutmann DH, Lal A.

Neoplasia. 2008 Nov;10(11):1204-12.

9.

Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species.

Bäumer AT, Ten Freyhaus H, Sauer H, Wartenberg M, Kappert K, Schnabel P, Konkol C, Hescheler J, Vantler M, Rosenkranz S.

J Biol Chem. 2008 Mar 21;283(12):7864-76. Epub 2007 Dec 10.

10.
11.

β1 integrin-dependent Rac/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2/merlin.

Sabra H, Brunner M, Mandati V, Wehrle-Haller B, Lallemand D, Ribba AS, Chevalier G, Guardiola P, Block MR, Bouvard D.

J Biol Chem. 2017 Nov 24;292(47):19179-19197. doi: 10.1074/jbc.M117.808063. Epub 2017 Sep 29.

PMID:
28972170
12.

Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1.

Kissil JL, Wilker EW, Johnson KC, Eckman MS, Yaffe MB, Jacks T.

Mol Cell. 2003 Oct;12(4):841-9.

13.

Neurofibromatosis 2 tumor suppressor, the gene induced by valproic acid, mediates neurite outgrowth through interaction with paxillin.

Yamauchi J, Miyamoto Y, Kusakawa S, Torii T, Mizutani R, Sanbe A, Nakajima H, Kiyokawa N, Tanoue A.

Exp Cell Res. 2008 Jul 1;314(11-12):2279-88. doi: 10.1016/j.yexcr.2008.03.019. Epub 2008 Apr 8.

PMID:
18486129
14.

Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas.

Lallemand D, Manent J, Couvelard A, Watilliaux A, Siena M, Chareyre F, Lampin A, Niwa-Kawakita M, Kalamarides M, Giovannini M.

Oncogene. 2009 Feb 12;28(6):854-65. doi: 10.1038/onc.2008.427. Epub 2008 Nov 24.

PMID:
19029950
15.

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.

del Pozo MA, Price LS, Alderson NB, Ren XD, Schwartz MA.

EMBO J. 2000 May 2;19(9):2008-14.

16.

Heregulin beta1 promotes breast cancer cell proliferation through Rac/ERK-dependent induction of cyclin D1 and p21Cip1.

Yang C, Klein EA, Assoian RK, Kazanietz MG.

Biochem J. 2008 Feb 15;410(1):167-75.

PMID:
17941827
17.

Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus.

Li W, Cooper J, Karajannis MA, Giancotti FG.

EMBO Rep. 2012 Mar;13(3):204-15. Review.

18.

The GTPase Rac regulates the proliferation and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients.

Chan A, Akhtar M, Brenner M, Zheng Y, Gulko PS, Symons M.

Mol Med. 2007 May-Jun;13(5-6):297-304.

20.

NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation.

Bosco EE, Nakai Y, Hennigan RF, Ratner N, Zheng Y.

Oncogene. 2010 Apr 29;29(17):2540-9. doi: 10.1038/onc.2010.20. Epub 2010 Feb 15.

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