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Items: 1 to 20 of 102


Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.

Baillat D, Hakimi MA, Näär AM, Shilatifard A, Cooch N, Shiekhattar R.

Cell. 2005 Oct 21;123(2):265-76.


Serine-7 of the RNA polymerase II CTD is specifically required for snRNA gene expression.

Egloff S, O'Reilly D, Chapman RD, Taylor A, Tanzhaus K, Pitts L, Eick D, Murphy S.

Science. 2007 Dec 14;318(5857):1777-9.


Role of the C-terminal domain of RNA polymerase II in U2 snRNA transcription and 3' processing.

Jacobs EY, Ogiwara I, Weiner AM.

Mol Cell Biol. 2004 Jan;24(2):846-55.


Integrator mediates the biogenesis of enhancer RNAs.

Lai F, Gardini A, Zhang A, Shiekhattar R.

Nature. 2015 Sep 17;525(7569):399-403. doi: 10.1038/nature14906. Epub 2015 Aug 26.


Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes.

Egloff S, Zaborowska J, Laitem C, Kiss T, Murphy S.

Mol Cell. 2012 Jan 13;45(1):111-22. doi: 10.1016/j.molcel.2011.11.006. Epub 2011 Dec 1.


A subset of Drosophila integrator proteins is essential for efficient U7 snRNA and spliceosomal snRNA 3'-end formation.

Ezzeddine N, Chen J, Waltenspiel B, Burch B, Albrecht T, Zhuo M, Warren WD, Marzluff WF, Wagner EJ.

Mol Cell Biol. 2011 Jan;31(2):328-41. doi: 10.1128/MCB.00943-10. Epub 2010 Nov 15.


The integrator complex recognizes a new double mark on the RNA polymerase II carboxyl-terminal domain.

Egloff S, Szczepaniak SA, Dienstbier M, Taylor A, Knight S, Murphy S.

J Biol Chem. 2010 Jul 2;285(27):20564-9. doi: 10.1074/jbc.M110.132530. Epub 2010 May 10.


CTD serine-2 plays a critical role in splicing and termination factor recruitment to RNA polymerase II in vivo.

Gu B, Eick D, Bensaude O.

Nucleic Acids Res. 2013 Feb 1;41(3):1591-603. doi: 10.1093/nar/gks1327. Epub 2012 Dec 28.


Expression of human snRNA genes from beginning to end.

Egloff S, O'Reilly D, Murphy S.

Biochem Soc Trans. 2008 Aug;36(Pt 4):590-4. doi: 10.1042/BST0360590. Review.


Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex.

Chen J, Waltenspiel B, Warren WD, Wagner EJ.

J Biol Chem. 2013 Feb 15;288(7):4867-77. doi: 10.1074/jbc.M112.425892. Epub 2013 Jan 3.


Role of the C-terminal domain of RNA polymerase II in expression of small nuclear RNA genes.

Egloff S, Murphy S.

Biochem Soc Trans. 2008 Jun;36(Pt 3):537-9. doi: 10.1042/BST0360537.


Role of Ser7 phosphorylation of the CTD during transcription of snRNA genes.

Egloff S.

RNA Biol. 2012 Aug;9(8):1033-8. doi: 10.4161/rna.21166. Epub 2012 Aug 1.


DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes.

Yamamoto J, Hagiwara Y, Chiba K, Isobe T, Narita T, Handa H, Yamaguchi Y.

Nat Commun. 2014 Jun 27;5:4263. doi: 10.1038/ncomms5263.


The RNA polymerase II C-terminal domain-interacting domain of yeast Nrd1 contributes to the choice of termination pathway and couples to RNA processing by the nuclear exosome.

Heo DH, Yoo I, Kong J, Lidschreiber M, Mayer A, Choi BY, Hahn Y, Cramer P, Buratowski S, Kim M.

J Biol Chem. 2013 Dec 20;288(51):36676-90. doi: 10.1074/jbc.M113.508267. Epub 2013 Nov 6.


The C-terminal domain of RNA polymerase II couples mRNA processing to transcription.

McCracken S, Fong N, Yankulov K, Ballantyne S, Pan G, Greenblatt J, Patterson SD, Wickens M, Bentley DL.

Nature. 1997 Jan 23;385(6614):357-61.


The Integrator complex controls the termination of transcription at diverse classes of gene targets.

Skaar JR, Ferris AL, Wu X, Saraf A, Khanna KK, Florens L, Washburn MP, Hughes SH, Pagano M.

Cell Res. 2015 Mar;25(3):288-305. doi: 10.1038/cr.2015.19. Epub 2015 Feb 13.


CDKF;1 and CDKD protein kinases regulate phosphorylation of serine residues in the C-terminal domain of Arabidopsis RNA polymerase II.

Hajheidari M, Farrona S, Huettel B, Koncz Z, Koncz C.

Plant Cell. 2012 Apr;24(4):1626-42. doi: 10.1105/tpc.112.096834. Epub 2012 Apr 30.


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