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Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and I(Kr).

Rajamani S, Anderson CL, Valdivia CR, Eckhardt LL, Foell JD, Robertson GA, Kamp TJ, Makielski JC, Anson BD, January CT.

Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1278-88.


Inhibition of the rapid component of the delayed rectifier potassium current in ventricular myocytes by angiotensin II via the AT1 receptor.

Wang YH, Shi CX, Dong F, Sheng JW, Xu YF.

Br J Pharmacol. 2008 May;154(2):429-39. doi: 10.1038/bjp.2008.95.


Isolation and characterization of I(Kr) in cardiac myocytes by Cs+ permeation.

Zhang S.

Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1038-49.


Interaction between the cardiac rapidly (IKr) and slowly (IKs) activating delayed rectifier potassium channels revealed by low K+-induced hERG endocytic degradation.

Guo J, Wang T, Yang T, Xu J, Li W, Fridman MD, Fisher JT, Zhang S.

J Biol Chem. 2011 Oct 7;286(40):34664-74. doi: 10.1074/jbc.M111.253351.


Involvement of caveolin in low K+-induced endocytic degradation of cell-surface human ether-a-go-go-related gene (hERG) channels.

Massaeli H, Sun T, Li X, Shallow H, Wu J, Xu J, Li W, Hanson C, Guo J, Zhang S.

J Biol Chem. 2010 Aug 27;285(35):27259-64. doi: 10.1074/jbc.M110.124909.


Extracellular K+ is a prerequisite for the function and plasma membrane stability of HERG channels.

Massaeli H, Guo J, Xu J, Zhang S.

Circ Res. 2010 Apr 2;106(6):1072-82. doi: 10.1161/CIRCRESAHA.109.215970.


Identification of Ikr kinetics and drug binding in native myocytes.

Zhou Q, Zygmunt AC, Cordeiro JM, Siso-Nadal F, Miller RE, Buzzard GT, Fox JJ.

Ann Biomed Eng. 2009 Jul;37(7):1294-309. doi: 10.1007/s10439-009-9690-5.


Kv11.1 (ERG1) K+ channels localize in cholesterol and sphingolipid enriched membranes and are modulated by membrane cholesterol.

Balijepalli RC, Delisle BP, Balijepalli SY, Foell JD, Slind JK, Kamp TJ, January CT.

Channels (Austin). 2007 Jul-Aug;1(4):263-72.


Mechanistic basis for type 2 long QT syndrome caused by KCNH2 mutations that disrupt conserved arginine residues in the voltage sensor.

McBride CM, Smith AM, Smith JL, Reloj AR, Velasco EJ, Powell J, Elayi CS, Bartos DC, Burgess DE, Delisle BP.

J Membr Biol. 2013 May;246(5):355-64. doi: 10.1007/s00232-013-9539-6.


Mechanism of loss of Kv11.1 K+ current in mutant T421M-Kv11.1-expressing rat ventricular myocytes: interaction of trafficking and gating.

Balijepalli SY, Lim E, Concannon SP, Chew CL, Holzem KE, Tester DJ, Ackerman MJ, Delisle BP, Balijepalli RC, January CT.

Circulation. 2012 Dec 11;126(24):2809-18. doi: 10.1161/CIRCULATIONAHA.112.118018.


Deciphering hERG channels: molecular basis of the rapid component of the delayed rectifier potassium current.

Jonsson MK, van der Heyden MA, van Veen TA.

J Mol Cell Cardiol. 2012 Sep;53(3):369-74. doi: 10.1016/j.yjmcc.2012.06.011. Review.


Characterization of the rapidly activating delayed rectifier potassium current, I (Kr), in HL-1 mouse atrial myocytes.

Toyoda F, Ding WG, Zankov DP, Omatsu-Kanbe M, Isono T, Horie M, Matsuura H.

J Membr Biol. 2010 Jun;235(2):73-87. doi: 10.1007/s00232-010-9257-2.


Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes.

Guo J, Massaeli H, Li W, Xu J, Luo T, Shaw J, Kirshenbaum LA, Zhang S.

J Pharmacol Exp Ther. 2007 Jun;321(3):911-20.


Expression of distinct ERG proteins in rat, mouse, and human heart. Relation to functional I(Kr) channels.

Pond AL, Scheve BK, Benedict AT, Petrecca K, Van Wagoner DR, Shrier A, Nerbonne JM.

J Biol Chem. 2000 Feb 25;275(8):5997-6006.


Single HERG delayed rectifier K+ channels expressed in Xenopus oocytes.

Zou A, Curran ME, Keating MT, Sanguinetti MC.

Am J Physiol. 1997 Mar;272(3 Pt 2):H1309-14.


Inhibition of lysosomal degradation rescues pentamidine-mediated decreases of K(IR)2.1 ion channel expression but not that of K(v)11.1.

Nalos L, de Boer TP, Houtman MJ, Rook MB, Vos MA, van der Heyden MA.

Eur J Pharmacol. 2011 Feb 10;652(1-3):96-103. doi: 10.1016/j.ejphar.2010.10.093.


A minK-HERG complex regulates the cardiac potassium current I(Kr).

McDonald TV, Yu Z, Ming Z, Palma E, Meyers MB, Wang KW, Goldstein SA, Fishman GI.

Nature. 1997 Jul 17;388(6639):289-92.


Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643.

Grunnet M, Abbruzzese J, Sachse FB, Sanguinetti MC.

Mol Pharmacol. 2011 Jan;79(1):1-9. doi: 10.1124/mol.110.067728.


Downregulation of the HERG (KCNH2) K(+) channel by ceramide: evidence for ubiquitin-mediated lysosomal degradation.

Chapman H, Ramström C, Korhonen L, Laine M, Wann KT, Lindholm D, Pasternack M, Törnquist K.

J Cell Sci. 2005 Nov 15;118(Pt 22):5325-34.

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