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Items: 1 to 20 of 194

1.

Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.

Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC.

Science. 2005 Oct 14;310(5746):306-10.

2.

Role of histone H3 lysine 27 methylation in Polycomb-group silencing.

Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y.

Science. 2002 Nov 1;298(5595):1039-43. Epub 2002 Sep 26.

3.

CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells.

Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC.

Nat Cell Biol. 2011 Jan;13(1):87-94. doi: 10.1038/ncb2139. Epub 2010 Dec 5.

4.

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27).

McCabe MT, Graves AP, Ganji G, Diaz E, Halsey WS, Jiang Y, Smitheman KN, Ott HM, Pappalardi MB, Allen KE, Chen SB, Della Pietra A 3rd, Dul E, Hughes AM, Gilbert SA, Thrall SH, Tummino PJ, Kruger RG, Brandt M, Schwartz B, Creasy CL.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2989-94. doi: 10.1073/pnas.1116418109. Epub 2012 Feb 8.

5.

Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells.

Fiskus W, Pranpat M, Balasis M, Herger B, Rao R, Chinnaiyan A, Atadja P, Bhalla K.

Mol Cancer Ther. 2006 Dec;5(12):3096-104.

7.

Substrate preferences of the EZH2 histone methyltransferase complex.

Martin C, Cao R, Zhang Y.

J Biol Chem. 2006 Mar 31;281(13):8365-70. Epub 2006 Jan 23.

8.
9.

Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer.

Gonzalez ME, DuPrie ML, Krueger H, Merajver SD, Ventura AC, Toy KA, Kleer CG.

Cancer Res. 2011 Mar 15;71(6):2360-70. doi: 10.1158/0008-5472.CAN-10-1933.

10.

Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2.

Friedman J, Cho WK, Chu CK, Keedy KS, Archin NM, Margolis DM, Karn J.

J Virol. 2011 Sep;85(17):9078-89. doi: 10.1128/JVI.00836-11. Epub 2011 Jun 29.

11.

Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27 histone modification.

Gherardi S, Ripoche D, Mikaelian I, Chanal M, Teinturier R, Goehrig D, Cordier-Bussat M, Zhang CX, Hennino A, Bertolino P.

Biochim Biophys Acta. 2017 Apr;1860(4):427-437. doi: 10.1016/j.bbagrm.2017.02.003. Epub 2017 Feb 12.

PMID:
28215965
13.

Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.

Kirmizis A, Bartley SM, Kuzmichev A, Margueron R, Reinberg D, Green R, Farnham PJ.

Genes Dev. 2004 Jul 1;18(13):1592-605.

14.

Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy.

Sasaki D, Imaizumi Y, Hasegawa H, Osaka A, Tsukasaki K, Choi YL, Mano H, Marquez VE, Hayashi T, Yanagihara K, Moriwaki Y, Miyazaki Y, Kamihira S, Yamada Y.

Haematologica. 2011 May;96(5):712-9. doi: 10.3324/haematol.2010.028605. Epub 2011 Jan 12.

15.

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.

Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH.

Mol Cell. 2008 Nov 21;32(4):491-502. doi: 10.1016/j.molcel.2008.10.016.

16.

The transcriptional repressor NIPP1 is an essential player in EZH2-mediated gene silencing.

Nuytten M, Beke L, Van Eynde A, Ceulemans H, Beullens M, Van Hummelen P, Fuks F, Bollen M.

Oncogene. 2008 Feb 28;27(10):1449-60. Epub 2007 Sep 3.

PMID:
17724462
17.

Epigenetic regulation of cell adhesion and communication by enhancer of zeste homolog 2 in human endothelial cells.

Dreger H, Ludwig A, Weller A, Stangl V, Baumann G, Meiners S, Stangl K.

Hypertension. 2012 Nov;60(5):1176-83. doi: 10.1161/HYPERTENSIONAHA.112.191098. Epub 2012 Sep 10.

18.

The polycomb group protein SUZ12 regulates histone H3 lysine 9 methylation and HP1 alpha distribution.

de la Cruz CC, Kirmizis A, Simon MD, Isono K, Koseki H, Panning B.

Chromosome Res. 2007;15(3):299-314. Epub 2007 May 10.

PMID:
17406994
19.

The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation.

Caretti G, Di Padova M, Micales B, Lyons GE, Sartorelli V.

Genes Dev. 2004 Nov 1;18(21):2627-38. Erratum in: Genes Dev. 2005 Mar 15;19(6):768.

20.

The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination.

Kogure M, Takawa M, Saloura V, Sone K, Piao L, Ueda K, Ibrahim R, Tsunoda T, Sugiyama M, Atomi Y, Nakamura Y, Hamamoto R.

Neoplasia. 2013 Nov;15(11):1251-61.

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