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Items: 1 to 20 of 88

1.

DSCR1 (ADAPT78) lethality: evidence for a protective effect of trisomy 21 genes?

Kluetzman KS, Perez AV, Crawford DR.

Biochem Biophys Res Commun. 2005 Nov 18;337(2):595-601. Epub 2005 Sep 22.

PMID:
16198305
3.

Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease.

Ermak G, Morgan TE, Davies KJ.

J Biol Chem. 2001 Oct 19;276(42):38787-94. Epub 2001 Aug 1.

6.

Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16.

Pash J, Popescu N, Matocha M, Rapoport S, Bustin M.

Proc Natl Acad Sci U S A. 1990 May;87(10):3836-40.

7.

A single extra copy of Dscr1 improves survival of mice developing spontaneous lung tumors through suppression of tumor angiogenesis.

Shin J, Lee JC, Baek KH.

Cancer Lett. 2014 Jan 1;342(1):70-81. doi: 10.1016/j.canlet.2013.08.047. Epub 2013 Sep 16.

PMID:
24051307
8.

Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease.

Harris CD, Ermak G, Davies KJ.

Cell Mol Life Sci. 2005 Nov;62(21):2477-86. Review.

PMID:
16231093
9.

Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis.

Casas C, Martínez S, Pritchard MA, Fuentes JJ, Nadal M, Guimerà J, Arbonés M, Flórez J, Soriano E, Estivill X, Alcántara S.

Mech Dev. 2001 Mar;101(1-2):289-92.

10.

DSCR1(Adapt78) modulates expression of SOD1.

Ermak G, Cheadle C, Becker KG, Harris CD, Davies KJ.

FASEB J. 2004 Jan;18(1):62-9. Erratum in: FASEB J. 2004 Feb;18(2):iv.

PMID:
14718387
11.

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR.

Nature. 2006 Jun 1;441(7093):595-600. Epub 2006 Mar 22.

PMID:
16554754
12.

Down syndrome critical region 1 enhances the proteolytic cleavage of calcineurin.

Lee JE, Jang H, Cho EJ, Youn HD.

Exp Mol Med. 2009 Jul 31;41(7):471-7. doi: 10.3858/emm.2009.41.7.052.

13.

DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease.

Keating DJ, Dubach D, Zanin MP, Yu Y, Martin K, Zhao YF, Chen C, Porta S, Arbonés ML, Mittaz L, Pritchard MA.

Hum Mol Genet. 2008 Apr 1;17(7):1020-30. doi: 10.1093/hmg/ddm374. Epub 2008 Jan 7.

PMID:
18180251
14.

Models for Down syndrome: chromosome 21-specific genes in mice.

Epstein CJ, Berger CN, Carlson EJ, Chan PH, Huang TT.

Prog Clin Biol Res. 1990;360:215-32. Review. No abstract available.

PMID:
2147287
15.

Global up-regulation of chromosome 21 gene expression in the developing Down syndrome brain.

Mao R, Zielke CL, Zielke HR, Pevsner J.

Genomics. 2003 May;81(5):457-67.

PMID:
12706104
17.

Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.

Dierssen M, Arqué G, McDonald J, Andreu N, Martínez-Cué C, Flórez J, Fillat C.

PLoS One. 2011 Feb 25;6(2):e17010. doi: 10.1371/journal.pone.0017010.

18.

Overexpression of DSCR1 blocks zinc-induced neuronal cell death through the formation of nuclear aggregates.

Lee EJ, Lee JY, Seo SR, Chung KC.

Mol Cell Neurosci. 2007 Aug;35(4):585-95. Epub 2007 May 18.

PMID:
17596961
19.

Association of metastin/a G-protein-coupled receptor signaling and Down syndrome critical region 1 in epithelial ovarian cancer.

Hata K, Watanabe Y, Nakai H, Minami T, Ohsaki H, Hirakawa E, Hoshiai H.

Anticancer Res. 2009 Feb;29(2):617-23.

20.

Transcriptional disruptions in Down syndrome: a case study in the Ts1Cje mouse cerebellum during post-natal development.

Potier MC, Rivals I, Mercier G, Ettwiller L, Moldrich RX, Laffaire J, Personnaz L, Rossier J, Dauphinot L.

J Neurochem. 2006 Apr;97 Suppl 1:104-9.

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