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Items: 1 to 20 of 109

1.

DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection.

Friedrich ML, Wen BG, Bain G, Kee BL, Katayama C, Murre C, Hedrick SM, Walsh CM.

Int Immunol. 2005 Nov;17(11):1379-90. Epub 2005 Sep 19.

PMID:
16172133
2.

Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development.

Gatzka M, Newton RH, Walsh CM.

J Immunol. 2009 Jul 1;183(1):285-97. doi: 10.4049/jimmunol.0803530.

3.
4.

Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity.

Ramos SJ, Hernandez JB, Gatzka M, Walsh CM.

J Immunol. 2008 Dec 1;181(11):7606-16.

5.

Modulation of DRAK2 autophosphorylation by antigen receptor signaling in primary lymphocytes.

Friedrich ML, Cui M, Hernandez JB, Weist BM, Andersen HM, Zhang X, Huang L, Walsh CM.

J Biol Chem. 2007 Feb 16;282(7):4573-84. Epub 2006 Dec 20.

6.

Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation.

Na SY, Patra A, Scheuring Y, Marx A, Tolaini M, Kioussis D, Hemmings BA, Hünig T, Bommhardt U.

J Immunol. 2003 Aug 1;171(3):1285-96. Erratum in: J Immunol. 2006 Feb 15;176(4):2669. Hemmings, Brian [corrected to Hemmings, Brian A].

7.

TCR engagement of CD4+CD8+ thymocytes in vitro induces early aspects of positive selection, but not apoptosis.

Groves T, Parsons M, Miyamoto NG, Guidos CJ.

J Immunol. 1997 Jan 1;158(1):65-75.

PMID:
8977176
8.

Defective thymocyte maturation by transgenic expression of a truncated form of the T lymphocyte adapter molecule and Fyn substrate, Sin.

Donlin LT, Roman CA, Adlam M, Regelmann AG, Alexandropoulos K.

J Immunol. 2002 Dec 15;169(12):6900-9. Erratum in: J Immunol. 2003 Feb 15;170(4):2242..

9.

The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes.

Rincón M, Whitmarsh A, Yang DD, Weiss L, Dérijard B, Jayaraj P, Davis RJ, Flavell RA.

J Exp Med. 1998 Nov 16;188(10):1817-30.

10.

Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.

Newton RH, Leverrier S, Srikanth S, Gwack Y, Cahalan MD, Walsh CM.

J Immunol. 2011 Jan 15;186(2):940-50. doi: 10.4049/jimmunol.1000942. Epub 2010 Dec 10.

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12.

Immature thymocyte antigen-1: a novel thymocyte marker discriminating pre- and post-selected thymocytes.

Kishi H, Tong JJ, Nagata T, Muraguchi A.

Int Immunol. 1998 Jul;10(7):951-60.

PMID:
9701033
13.

CD45 can act as a negative regulator for the transition from early to late CD4+ CD8+ thymocytes.

Sato T, Nunomura S, Sato C, Hozumi K, Kumagai Y, Nishimura T, Mak TW, Kishihara K, Habu S.

Int Immunol. 1999 Jan;11(1):89-97.

PMID:
10050677
14.

Activation of Cdk2 is a requirement for antigen-mediated thymic negative selection.

Williams O, Gil-Gómez G, Norton T, Kioussis D, Brady HJ.

Eur J Immunol. 2000 Feb;30(2):709-13.

15.

A requirement for IL-2/IL-2 receptor signaling in intrathymic negative selection.

Bassiri H, Carding SR.

J Immunol. 2001 May 15;166(10):5945-54.

17.

Transgenic drak2 overexpression in mice leads to increased T cell apoptosis and compromised memory T cell development.

Mao J, Qiao X, Luo H, Wu J.

J Biol Chem. 2006 May 5;281(18):12587-95. Epub 2006 Mar 3.

18.

Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation.

Vespa GN, Lewis LA, Kozak KR, Moran M, Nguyen JT, Baum LG, Miceli MC.

J Immunol. 1999 Jan 15;162(2):799-806.

19.

Con A activates an Akt/PKB dependent survival mechanism to modulate TCR induced cell death in double positive thymocytes.

Pongracz J, Parnell S, Anderson G, Jaffrézou JP, Jenkinson E.

Mol Immunol. 2003 Jun;39(16):1013-23.

PMID:
12749908
20.

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