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Items: 1 to 20 of 68

1.

DNA damage regulates Chk2 association with chromatin.

Li J, Stern DF.

J Biol Chem. 2005 Nov 11;280(45):37948-56. Epub 2005 Sep 8.

2.

Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.

Bahassi el M, Myer DL, McKenney RJ, Hennigan RF, Stambrook PJ.

Mutat Res. 2006 Apr 11;596(1-2):166-76. Epub 2006 Feb 14.

PMID:
16481012
3.

Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner.

Gibson SL, Bindra RS, Glazer PM.

Cancer Res. 2005 Dec 1;65(23):10734-41.

5.

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.

Lou Z, Minter-Dykhouse K, Wu X, Chen J.

Nature. 2003 Feb 27;421(6926):957-61.

PMID:
12607004
6.

Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation.

Wei F, Xie Y, Tao L, Tang D.

Cell Signal. 2010 Nov;22(11):1783-9. doi: 10.1016/j.cellsig.2010.07.007. Epub 2010 Jul 15.

PMID:
20637859
7.

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.

Ziv Y, Bielopolski D, Galanty Y, Lukas C, Taya Y, Schultz DC, Lukas J, Bekker-Jensen S, Bartek J, Shiloh Y.

Nat Cell Biol. 2006 Aug;8(8):870-6. Epub 2006 Jul 23.

PMID:
16862143
8.
9.

Constitutive phosphorylation of ATM in lymphoblastoid cell lines from patients with ICF syndrome without downstream kinase activity.

Goldstine JV, Nahas S, Gamo K, Gartler SM, Hansen RS, Roelfsema JH, Gatti RA, Marahrens Y.

DNA Repair (Amst). 2006 Apr 8;5(4):432-43. Epub 2006 Jan 19.

PMID:
16426903
10.

ATR dependent activation of Chk2.

Wang XQ, Redpath JL, Fan ST, Stanbridge EJ.

J Cell Physiol. 2006 Sep;208(3):613-9.

PMID:
16741947
11.

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity.

Zhou BB, Chaturvedi P, Spring K, Scott SP, Johanson RA, Mishra R, Mattern MR, Winkler JD, Khanna KK.

J Biol Chem. 2000 Apr 7;275(14):10342-8.

12.

Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair.

Zhang J, Willers H, Feng Z, Ghosh JC, Kim S, Weaver DT, Chung JH, Powell SN, Xia F.

Mol Cell Biol. 2004 Jan;24(2):708-18.

13.

Cell cycle-dependent DNA damage signaling induced by ICRF-193 involves ATM, ATR, CHK2, and BRCA1.

Park I, Avraham HK.

Exp Cell Res. 2006 Jul 1;312(11):1996-2008. Epub 2006 Apr 21.

PMID:
16630610
14.

Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.

Young DB, Jonnalagadda J, Gatei M, Jans DA, Meyn S, Khanna KK.

J Biol Chem. 2005 Jul 29;280(30):27587-94. Epub 2005 Jun 1.

15.

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.

Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ.

Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10389-94.

16.

E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis.

Powers JT, Hong S, Mayhew CN, Rogers PM, Knudsen ES, Johnson DG.

Mol Cancer Res. 2004 Apr;2(4):203-14.

17.

The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.

Ye R, Bodero A, Zhou BB, Khanna KK, Lavin MF, Lees-Miller SP.

J Biol Chem. 2001 Feb 16;276(7):4828-33. Epub 2000 Nov 28.

18.

Restoration of fragile histidine triad expression restores Chk2 activity in response to ionizing radiation in oral squamous cell carcinoma cells.

Yutori H, Semba S, Komori T, Yokozaki H.

Cancer Sci. 2008 Mar;99(3):524-30. doi: 10.1111/j.1349-7006.2007.00707.x. Epub 2007 Dec 27.

19.

Cellular processing determinants for the activation of damage signals in response to topoisomerase I-linked DNA breakage.

Huang TH, Chen HC, Chou SM, Yang YC, Fan JR, Li TK.

Cell Res. 2010 Sep;20(9):1060-75. doi: 10.1038/cr.2010.95. Epub 2010 Jul 6.

PMID:
20603643
20.

Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responses.

Fan JR, Huang TH, Wen CY, Shen TL, Li TK.

Eur J Pharmacol. 2010 Jul 25;638(1-3):13-20. doi: 10.1016/j.ejphar.2010.04.012. Epub 2010 Apr 18.

PMID:
20406630

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