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Items: 1 to 20 of 214


A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.

Sun Y, Jiang X, Chen S, Fernandes N, Price BD.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13182-7. Epub 2005 Sep 2.


DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.

Sun Y, Xu Y, Roy K, Price BD.

Mol Cell Biol. 2007 Dec;27(24):8502-9. Epub 2007 Oct 8.


The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.

Jiang X, Sun Y, Chen S, Roy K, Price BD.

J Biol Chem. 2006 Jun 9;281(23):15741-6. Epub 2006 Apr 9.


Tip60 in DNA damage response and growth control: many tricks in one HAT.

Squatrito M, Gorrini C, Amati B.

Trends Cell Biol. 2006 Sep;16(9):433-42. Epub 2006 Aug 9. Review.


Tip60: connecting chromatin to DNA damage signaling.

Sun Y, Jiang X, Price BD.

Cell Cycle. 2010 Mar 1;9(5):930-6. Epub 2010 Mar 11. Review.


Mechanistic links between ATM and histone methylation codes during DNA repair.

Xu Y, Xu C, Price BD.

Prog Mol Biol Transl Sci. 2012;110:263-88. doi: 10.1016/B978-0-12-387665-2.00010-9. Review.


Regulation of TIP60 by ATF2 modulates ATM activation.

Bhoumik A, Singha N, O'Connell MJ, Ronai ZA.

J Biol Chem. 2008 Jun 20;283(25):17605-14. doi: 10.1074/jbc.M802030200. Epub 2008 Apr 8.


p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress.

Eymin B, Claverie P, Salon C, Leduc C, Col E, Brambilla E, Khochbin S, Gazzeri S.

Mol Cell Biol. 2006 Jun;26(11):4339-50.


Involvement of human MOF in ATM function.

Gupta A, Sharma GG, Young CS, Agarwal M, Smith ER, Paull TT, Lucchesi JC, Khanna KK, Ludwig T, Pandita TK.

Mol Cell Biol. 2005 Jun;25(12):5292-305.


Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.

Coffey K, Blackburn TJ, Cook S, Golding BT, Griffin RJ, Hardcastle IR, Hewitt L, Huberman K, McNeill HV, Newell DR, Roche C, Ryan-Munden CA, Watson A, Robson CN.

PLoS One. 2012;7(10):e45539. doi: 10.1371/journal.pone.0045539. Epub 2012 Oct 8.


Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation.

Kobayashi J, Kato A, Ota Y, Ohba R, Komatsu K.

Mol Cancer. 2010 Feb 9;9:34. doi: 10.1186/1476-4598-9-34.


ATM regulates ATR chromatin loading in response to DNA double-strand breaks.

Cuadrado M, Martinez-Pastor B, Murga M, Toledo LI, Gutierrez-Martinez P, Lopez E, Fernandez-Capetillo O.

J Exp Med. 2006 Feb 20;203(2):297-303. Epub 2006 Feb 6.


DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.

Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD.

J Biol Chem. 2005 Apr 15;280(15):15158-64. Epub 2005 Feb 15.


Specific role for p300/CREB-binding protein-associated factor activity in E2F1 stabilization in response to DNA damage.

Ianari A, Gallo R, Palma M, Alesse E, Gulino A.

J Biol Chem. 2004 Jul 16;279(29):30830-5. Epub 2004 May 3.


Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation.

Sun Y, Jiang X, Chen S, Price BD.

FEBS Lett. 2006 Aug 7;580(18):4353-6. Epub 2006 Jul 10.


Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.

Bahassi el M, Myer DL, McKenney RJ, Hennigan RF, Stambrook PJ.

Mutat Res. 2006 Apr 11;596(1-2):166-76. Epub 2006 Feb 14.


Aven-dependent activation of ATM following DNA damage.

Guo JY, Yamada A, Kajino T, Wu JQ, Tang W, Freel CD, Feng J, Chau BN, Wang MZ, Margolis SS, Yoo HY, Wang XF, Dunphy WG, Irusta PM, Hardwick JM, Kornbluth S.

Curr Biol. 2008 Jul 8;18(13):933-42. doi: 10.1016/j.cub.2008.05.045. Epub 2008 Jun 19.


MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii.

Vonlaufen N, Naguleswaran A, Coppens I, Sullivan WJ Jr.

J Biol Chem. 2010 Apr 9;285(15):11154-61. doi: 10.1074/jbc.M109.066134. Epub 2010 Feb 16.


KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling.

Kaidi A, Jackson SP.

Nature. 2013 Jun 6;498(7452):70-4. doi: 10.1038/nature12201. Epub 2013 May 26.


Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.

Falck J, Coates J, Jackson SP.

Nature. 2005 Mar 31;434(7033):605-11. Epub 2005 Mar 2.


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