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Items: 1 to 20 of 227

1.

Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines .

Sauerberg P, Olesen PH, Nielsen S, Treppendahl S, Sheardown MJ, Honoré T, Mitch CH, Ward JS, Pike AJ, Bymaster FP, et al.

J Med Chem. 1992 Jun 12;35(12):2274-83.

PMID:
1613751
2.
3.

Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore.

Ward JS, Merritt L, Klimkowski VJ, Lamb ML, Mitch CH, Bymaster FP, Sawyer B, Shannon HE, Olesen PH, Honoré T, et al.

J Med Chem. 1992 Oct 30;35(22):4011-9.

PMID:
1433209
4.

M1 receptor agonist activity is not a requirement for muscarinic antinociception.

Sheardown MJ, Shannon HE, Swedberg MD, Suzdak PD, Bymaster FP, Olesen PH, Mitch CH, Ward JS, Sauerberg P.

J Pharmacol Exp Ther. 1997 May;281(2):868-75.

5.

Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors.

Shannon HE, Bymaster FP, Calligaro DO, Greenwood B, Mitch CH, Sawyer BD, Ward JS, Wong DT, Olesen PH, Sheardown MJ, Swedberg MD, Suzdak PD, Sauerberg P.

J Pharmacol Exp Ther. 1994 Apr;269(1):271-81.

PMID:
7909557
6.

Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity.

Sauerberg P, Olesen PH, Sheardown MJ, Rimvall K, Thøgersen H, Shannon HE, Sawyer BD, Ward JS, Bymaster FP, DeLapp NW, Calligaro DO, Swedberg MD.

J Med Chem. 1998 Jan 1;41(1):109-16.

PMID:
9438027
7.

Muscarinic M1 receptor agonist actions of muscarinic receptor agonists in rabbit vas deferens.

Shannon HE, Sawyer BD, Bemis KG, Bymaster FP, Health I, Mitch CH, Ward JS.

Eur J Pharmacol. 1993 Feb 23;232(1):47-57.

PMID:
8458395
8.

The design and pharmacology of novel selective muscarinic agonists and antagonists.

Lambrecht G, Gross J, Hacksell U, Hermanni U, Hildebrandt C, Hou X, Moser U, Nilsson BM, Pfaff O, Waelbroeck M, et al.

Life Sci. 1995;56(11-12):815-22.

PMID:
10188780
9.

Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M.

Dallanoce C, Conti P, De Amici M, De Micheli C, Barocelli E, Chiavarini M, Ballabeni V, Bertoni S, Impicciatore M.

Bioorg Med Chem. 1999 Aug;7(8):1539-47.

PMID:
10482446
10.
11.

Stereoselective recognition of the enantiomers of phenglutarimide and of six related compounds by four muscarinic receptor subtypes.

Waelbroeck M, Lazareno S, Pfaff O, Friebe T, Tastenoy M, Mutschler E, Lambrecht G.

Br J Pharmacol. 1996 Dec;119(7):1319-30.

12.
14.

Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.

Dunbar PG, Durant GJ, Fang Z, Abuh YF, el-Assadi AA, Ngur DO, Periyasamy S, Hoss WP, Messer WS Jr.

J Med Chem. 1993 Apr 2;36(7):842-7.

PMID:
8464038
15.

Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity: SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs.

Sauerberg P, Olesen PH, Sheardown MJ, Suzdak PD, Shannon HE, Bymaster FP, Calligaro DO, Mitch CH, Ward JS, Swedberg MD.

Life Sci. 1995;56(11-12):807-14.

PMID:
10188779
16.

Pharmacology of butylthio[2.2.2] (LY297802/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity.

Shannon HE, Sheardown MJ, Bymaster FP, Calligaro DO, Delapp NW, Gidda J, Mitch CH, Sawyer BD, Stengel PW, Ward JS, Wong DT, Olesen PH, Suzdak PD, Sauerberg P, Swedberg MD.

J Pharmacol Exp Ther. 1997 May;281(2):884-94.

17.
18.

New analogues of oxotremorine and oxotremorine-M: estimation of their in vitro affinity and efficacy at muscarinic receptor subtypes.

Barocelli E, Ballabeni V, Bertoni S, Dallanoce C, De Amici M, De Micheli C, Impicciatore M.

Life Sci. 2000 Jun 30;67(6):717-23.

PMID:
12659177
19.

Deoxamuscaroneoxime derivatives as useful muscarinic agonists to explore the muscarinic subsite: demox, a modulator of orthosteric and allosteric sites at cardiac muscarinic M2 receptors.

Angeli P, Marucci G, Buccioni M, Piergentili A, Giannella M, Quaglia W, Pigini M, Cantalamessa F, Nasuti C, Novi F, Maggio R, Qasem AR, Spampinato S.

Life Sci. 2002 Feb 8;70(12):1427-46.

PMID:
11883718
20.

Pharmacological properties of (2R)-N-[1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: a novel mucarinic antagonist with M(2)-sparing antagonistic activity.

Hirose H, Aoki I, Kimura T, Fujikawa T, Numazawa T, Sasaki K, Sato A, Hasegawa T, Nishikibe M, Mitsuya M, Ohtake N, Mase T, Noguchi K.

J Pharmacol Exp Ther. 2001 May;297(2):790-7.

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