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Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor.

Roncagalli R, Taylor JE, Zhang S, Shi X, Chen R, Cruz-Munoz ME, Yin L, Latour S, Veillette A.

Nat Immunol. 2005 Oct;6(10):1002-10. Epub 2005 Aug 28.


NK cell regulation by SLAM family receptors and SAP-related adapters.

Veillette A.

Immunol Rev. 2006 Dec;214:22-34. Review.


Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors.

Chen R, Relouzat F, Roncagalli R, Aoukaty A, Tan R, Latour S, Veillette A.

Mol Cell Biol. 2004 Jun;24(12):5144-56.


Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP.

Tangye SG, Lazetic S, Woollatt E, Sutherland GR, Lanier LL, Phillips JH.

J Immunol. 1999 Jun 15;162(12):6981-5.


Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells.

Dong Z, Cruz-Munoz ME, Zhong MC, Chen R, Latour S, Veillette A.

Nat Immunol. 2009 Sep;10(9):973-80. doi: 10.1038/ni.1763. Epub 2009 Aug 2.


EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization.

Pérez-Quintero LA, Roncagalli R, Guo H, Latour S, Davidson D, Veillette A.

J Exp Med. 2014 Apr 7;211(4):727-42. doi: 10.1084/jem.20132038. Epub 2014 Mar 31.


Fine-tuning NK cell responses: it's a family affair.

Colonna M.

Nat Immunol. 2005 Oct;6(10):961-2. No abstract available.


B cell induction of IL-13 expression in NK cells: role of CD244 and SLAM-associated protein.

Gao N, Schwartzberg P, Wilder JA, Blazar BR, Yuan D.

J Immunol. 2006 Mar 1;176(5):2758-64.


Potential pathways for regulation of NK and T cell responses: differential X-linked lymphoproliferative syndrome gene product SAP interactions with SLAM and 2B4.

Sayós J, Nguyen KB, Wu C, Stepp SE, Howie D, Schatzle JD, Kumar V, Biron CA, Terhorst C.

Int Immunol. 2000 Dec;12(12):1749-57.


Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244).

Eissmann P, Beauchamp L, Wooters J, Tilton JC, Long EO, Watzl C.

Blood. 2005 Jun 15;105(12):4722-9. Epub 2005 Feb 15.


Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn.

Bloch-Queyrat C, Fondanèche MC, Chen R, Yin L, Relouzat F, Veillette A, Fischer A, Latour S.

J Exp Med. 2005 Jul 4;202(1):181-92.


Dynamic redistribution of the activating 2B4/SAP complex at the cytotoxic NK cell immune synapse.

Roda-Navarro P, Mittelbrunn M, Ortega M, Howie D, Terhorst C, Sánchez-Madrid F, Fernández-Ruiz E.

J Immunol. 2004 Sep 15;173(6):3640-6.


Fine specificity and molecular competition in SLAM family receptor signalling.

Wilson TJ, Garner LI, Metcalfe C, King E, Margraf S, Brown MH.

PLoS One. 2014 Mar 18;9(3):e92184. doi: 10.1371/journal.pone.0092184. eCollection 2014.


The murine NK receptor 2B4 (CD244) exhibits inhibitory function independent of signaling lymphocytic activation molecule-associated protein expression.

Mooney JM, Klem J, Wülfing C, Mijares LA, Schwartzberg PL, Bennett M, Schatzle JD.

J Immunol. 2004 Sep 15;173(6):3953-61.


The adaptor protein 3BP2 binds human CD244 and links this receptor to Vav signaling, ERK activation, and NK cell killing.

Saborit-Villarroya I, Del Valle JM, Romero X, Esplugues E, Lauzurica P, Engel P, Martín M.

J Immunol. 2005 Oct 1;175(7):4226-35.


Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.

Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C.

EMBO J. 2001 Nov 1;20(21):5840-52.

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