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Items: 1 to 20 of 106


The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions.

Simeoni L, Posevitz V, Kölsch U, Meinert I, Bruyns E, Pfeffer K, Reinhold D, Schraven B.

Mol Cell Biol. 2005 Sep;25(17):7557-68.


SIT and TRIM determine T cell fate in the thymus.

Koelsch U, Schraven B, Simeoni L.

J Immunol. 2008 Nov 1;181(9):5930-9.


The transmembrane adaptor protein SIT inhibits TCR-mediated signaling.

Arndt B, Krieger T, Kalinski T, Thielitz A, Reinhold D, Roessner A, Schraven B, Simeoni L.

PLoS One. 2011;6(9):e23761. doi: 10.1371/journal.pone.0023761. Epub 2011 Sep 21.


Bcl10/Malt1 signaling is essential for TCR-induced NF-kappaB activation in thymocytes but dispensable for positive or negative selection.

Jost PJ, Weiss S, Ferch U, Gross O, Mak TW, Peschel C, Ruland J.

J Immunol. 2007 Jan 15;178(2):953-60.


Normal T-cell development and immune functions in TRIM-deficient mice.

Kölsch U, Arndt B, Reinhold D, Lindquist JA, Jüling N, Kliche S, Pfeffer K, Bruyns E, Schraven B, Simeoni L.

Mol Cell Biol. 2006 May;26(9):3639-48.


Contributions of the T cell receptor-associated CD3gamma-ITAM to thymocyte selection.

Haks MC, Pépin E, van den Brakel JH, Smeele SA, Belkowski SM, Kessels HW, Krimpenfort P, Kruisbeek AM.

J Exp Med. 2002 Jul 1;196(1):1-13.


CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling.

Ho KC, Chiang YJ, Lai AC, Liao NS, Chang YJ, Yang-Yen HF, Yen JJ.

Cell Death Dis. 2014 Nov 13;5:e1518. doi: 10.1038/cddis.2014.474.


A shift from negative to positive selection of autoreactive T cells by the reduced level of TCR signal in TCR-transgenic CD3 zeta-deficient mice.

Yamazaki T, Arase H, Ono S, Ohno H, Watanabe H, Saito T.

J Immunol. 1997 Feb 15;158(4):1634-40.


Dampening of death pathways by schnurri-2 is essential for T-cell development.

Staton TL, Lazarevic V, Jones DC, Lanser AJ, Takagi T, Ishii S, Glimcher LH.

Nature. 2011 Apr 7;472(7341):105-9. doi: 10.1038/nature09848.


Programmed death-1 (PD-1):PD-ligand 1 interactions inhibit TCR-mediated positive selection of thymocytes.

Keir ME, Latchman YE, Freeman GJ, Sharpe AH.

J Immunol. 2005 Dec 1;175(11):7372-9.


Impaired thymic selection in mice expressing altered levels of the SLP-76 adaptor protein.

Ramsey K, Luckashenak N, Koretzky GA, Clements JL.

J Leukoc Biol. 2008 Feb;83(2):419-29. Epub 2007 Oct 26.


The orphan adapter protein SLY1 as a novel anti-apoptotic protein required for thymocyte development.

Reis B, Pfeffer K, Beer-Hammer S.

BMC Immunol. 2009 Jul 15;10:38. doi: 10.1186/1471-2172-10-38.


Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development.

Gatzka M, Newton RH, Walsh CM.

J Immunol. 2009 Jul 1;183(1):285-97. doi: 10.4049/jimmunol.0803530.


Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire.

Shores EW, Tran T, Grinberg A, Sommers CL, Shen H, Love PE.

J Exp Med. 1997 Mar 3;185(5):893-900.


The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus.

Tao W, Teh SJ, Melhado I, Jirik F, Korsmeyer SJ, Teh HS.

J Exp Med. 1994 Jan 1;179(1):145-53.


Expression of the Bcl-2 family member A1 is developmentally regulated in T cells.

Tomayko MM, Punt JA, Bolcavage JM, Levy SL, Allman DM, Cancro MP.

Int Immunol. 1999 Nov;11(11):1753-61.


Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient mice.

DeKoning J, DiMolfetto L, Reilly C, Wei Q, Havran WL, Lo D.

J Immunol. 1997 Mar 15;158(6):2558-66.


Diethylstilbestrol alters positive and negative selection of T cells in the thymus and modulates T-cell repertoire in the periphery.

Brown N, Nagarkatti M, Nagarkatti PS.

Toxicol Appl Pharmacol. 2006 Apr 15;212(2):119-26. Epub 2005 Aug 24.


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