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Items: 1 to 20 of 221

1.

Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding.

Zhu J, Balan V, Bronisz A, Balan K, Sun H, Leicht DT, Luo Z, Qin J, Avruch J, Tzivion G.

Mol Biol Cell. 2005 Oct;16(10):4733-44. Epub 2005 Aug 10.

2.

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

Alessi DR, Saito Y, Campbell DG, Cohen P, Sithanandam G, Rapp U, Ashworth A, Marshall CJ, Cowley S.

EMBO J. 1994 Apr 1;13(7):1610-9.

3.

Regulation of Raf through phosphorylation and N terminus-C terminus interaction.

Chong H, Guan KL.

J Biol Chem. 2003 Sep 19;278(38):36269-76. Epub 2003 Jul 14.

4.

Protein kinase C alpha activates RAF-1 by direct phosphorylation.

Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Finkenzeller G, Marmé D, Rapp UR.

Nature. 1993 Jul 15;364(6434):249-52.

PMID:
8321321
5.

Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf-->MEK-->ERK pathway.

Woodrow MA, Woods D, Cherwinski HM, Stokoe D, McMahon M.

Exp Cell Res. 2003 Jul 15;287(2):325-38.

PMID:
12837288
6.

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.

Mason CS, Springer CJ, Cooper RG, Superti-Furga G, Marshall CJ, Marais R.

EMBO J. 1999 Apr 15;18(8):2137-48.

7.

Raf: a strategic target for therapeutic development against cancer.

Beeram M, Patnaik A, Rowinsky EK.

J Clin Oncol. 2005 Sep 20;23(27):6771-90. Review.

PMID:
16170185
8.

B-Raf is critical for MAPK activation during mitosis and is regulated in an M phase-dependent manner in Xenopus egg extracts.

Borysov SI, Cheng AW, Guadagno TM.

J Biol Chem. 2006 Aug 11;281(32):22586-96. Epub 2006 Jun 8.

9.

Mutations in conserved regions 1, 2, and 3 of Raf-1 that activate transforming activity.

Chan EY, Stang SL, Bottorff DA, Stone JC.

Mol Carcinog. 2002 Apr;33(4):189-97.

PMID:
11933072
10.

Activated raf induces the hyperphosphorylation of stathmin and the reorganization of the microtubule network.

Lovrić J, Dammeier S, Kieser A, Mischak H, Kolch W.

J Biol Chem. 1998 Aug 28;273(35):22848-55.

11.
12.

Regulation of the Raf-1 kinase domain by phosphorylation and 14-3-3 association.

Yip-Schneider MT, Miao W, Lin A, Barnard DS, Tzivion G, Marshall MS.

Biochem J. 2000 Oct 1;351(Pt 1):151-9.

13.

Detection of kinases that phosphorylate 14-3-3 binding sites of Raf-1 using in situ gel kinase assay.

Kinuya M, Takishima K, Mamiya G.

Biol Pharm Bull. 2000 Oct;23(10):1158-62.

PMID:
11041243
14.

A different function for a critical tryptophan in c-Raf and Hck.

McPherson RA, Taylor MM, Hershey ED, Sturgill TW.

Oncogene. 2000 Jul 27;19(32):3616-22.

15.

Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites.

Baljuls A, Schmitz W, Mueller T, Zahedi RP, Sickmann A, Hekman M, Rapp UR.

J Biol Chem. 2008 Oct 3;283(40):27239-54. doi: 10.1074/jbc.M801782200. Epub 2008 Jul 28.

16.

Phosphorylation of c-Raf-1 by protein kinase A interferes with activation.

Schramm K, Niehof M, Radziwill G, Rommel C, Moelling K.

Biochem Biophys Res Commun. 1994 Jun 15;201(2):740-7.

PMID:
8003010
17.

Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells.

Yip-Schneider MT, Klein PJ, Wentz SC, Zeni A, Menze A, Schmidt CM.

J Pharmacol Exp Ther. 2009 Jun;329(3):1063-70. doi: 10.1124/jpet.108.147306. Epub 2009 Mar 3.

18.

Role of raf proteins in cardiac hypertrophy and cardiomyocyte survival.

Muslin AJ.

Trends Cardiovasc Med. 2005 Aug;15(6):225-9. Review.

PMID:
16182133
19.

Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase.

Balan V, Leicht DT, Zhu J, Balan K, Kaplun A, Singh-Gupta V, Qin J, Ruan H, Comb MJ, Tzivion G.

Mol Biol Cell. 2006 Mar;17(3):1141-53. Epub 2006 Jan 11.

20.

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