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Items: 1 to 20 of 117

1.

WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism.

Xu BE, Stippec S, Lazrak A, Huang CL, Cobb MH.

J Biol Chem. 2005 Oct 7;280(40):34218-23. Epub 2005 Aug 4.

2.

WNK1 activates SGK1 to regulate the epithelial sodium channel.

Xu BE, Stippec S, Chu PY, Lazrak A, Li XJ, Lee BH, English JM, Ortega B, Huang CL, Cobb MH.

Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10315-20. Epub 2005 Jul 8.

3.

Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1.

Cheng CJ, Huang CL.

J Am Soc Nephrol. 2011 Mar;22(3):460-71. doi: 10.1681/ASN.2010060681. Epub 2011 Feb 25.

4.

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate.

Vitari AC, Deak M, Collins BJ, Morrice N, Prescott AR, Phelan A, Humphreys S, Alessi DR.

Biochem J. 2004 Feb 15;378(Pt 1):257-68.

5.

Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.

Heise CJ, Xu BE, Deaton SL, Cha SK, Cheng CJ, Earnest S, Sengupta S, Juang YC, Stippec S, Xu Y, Zhao Y, Huang CL, Cobb MH.

J Biol Chem. 2010 Aug 13;285(33):25161-7. doi: 10.1074/jbc.M110.103432. Epub 2010 Jun 4.

6.

Glucocorticoids can activate the alpha-ENaC gene promoter independently of SGK1.

McTavish N, Getty J, Burchell A, Wilson SM.

Biochem J. 2009 Sep 25;423(2):189-97. doi: 10.1042/BJ20090366.

7.

Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cells.

Flores SY, Loffing-Cueni D, Kamynina E, Daidié D, Gerbex C, Chabanel S, Dudler J, Loffing J, Staub O.

J Am Soc Nephrol. 2005 Aug;16(8):2279-87. Epub 2005 Jun 15.

8.

NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions.

Pao AC, McCormick JA, Li H, Siu J, Govaerts C, Bhalla V, Soundararajan R, Pearce D.

Am J Physiol Renal Physiol. 2007 Jun;292(6):F1741-50. Epub 2007 Mar 13.

9.

Regulation of a third conserved phosphorylation site in SGK1.

Chen W, Chen Y, Xu BE, Juang YC, Stippec S, Zhao Y, Cobb MH.

J Biol Chem. 2009 Feb 6;284(6):3453-60. doi: 10.1074/jbc.M807502200. Epub 2008 Dec 9.

10.

Insulin upregulates the expression of epithelial sodium channel in vitro and in a mouse model of acute lung injury: role of mTORC2/SGK1 pathway.

He J, Qi D, Wang DX, Deng W, Ye Y, Feng LH, Zhu T, Zhao Y, Zhang CR.

Exp Cell Res. 2015 Feb 1;331(1):164-75. doi: 10.1016/j.yexcr.2014.09.024. Epub 2014 Sep 28.

PMID:
25265063
11.

Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.

Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP.

J Biol Chem. 2005 Jun 3;280(22):21622-8. Epub 2005 Mar 30.

13.

mTOR complex-2 activates ENaC by phosphorylating SGK1.

Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D.

J Am Soc Nephrol. 2010 May;21(5):811-8. doi: 10.1681/ASN.2009111168. Epub 2010 Mar 25.

14.

The neuronal-specific SGK1.1 kinase regulates {delta}-epithelial Na+ channel independently of PY motifs and couples it to phospholipase C signaling.

Wesch D, Miranda P, Afonso-Oramas D, Althaus M, Castro-Hernández J, Dominguez J, Morty RE, Clauss W, González-Hernández T, Alvarez de la Rosa D, Giraldez T.

Am J Physiol Cell Physiol. 2010 Oct;299(4):C779-90. doi: 10.1152/ajpcell.00184.2010. Epub 2010 Jul 14.

15.

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II.

Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH.

J Biol Chem. 2000 Jun 2;275(22):16795-801.

16.

Regulation of the Ca(2+) channel TRPV6 by the kinases SGK1, PKB/Akt, and PIKfyve.

Sopjani M, Kunert A, Czarkowski K, Klaus F, Laufer J, Föller M, Lang F.

J Membr Biol. 2010 Feb;233(1-3):35-41. doi: 10.1007/s00232-009-9222-0. Epub 2009 Dec 30.

PMID:
20041238
17.

SGK1 kinase upregulates GLUT1 activity and plasma membrane expression.

Palmada M, Boehmer C, Akel A, Rajamanickam J, Jeyaraj S, Keller K, Lang F.

Diabetes. 2006 Feb;55(2):421-7.

18.

Regulation of WNK1 by an autoinhibitory domain and autophosphorylation.

Xu BE, Min X, Stippec S, Lee BH, Goldsmith EJ, Cobb MH.

J Biol Chem. 2002 Dec 13;277(50):48456-62. Epub 2002 Oct 8.

19.

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism.

Xu BE, Stippec S, Lenertz L, Lee BH, Zhang W, Lee YK, Cobb MH.

J Biol Chem. 2004 Feb 27;279(9):7826-31. Epub 2003 Dec 16.

20.

Hypotonic induction of SGK1 and Na+ transport in A6 cells.

Rozansky DJ, Wang J, Doan N, Purdy T, Faulk T, Bhargava A, Dawson K, Pearce D.

Am J Physiol Renal Physiol. 2002 Jul;283(1):F105-13.

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