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Items: 1 to 20 of 225

1.

Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design.

Karki RG, Tang Y, Burke TR Jr, Nicklaus MC.

J Comput Aided Mol Des. 2004 Dec;18(12):739-60. Epub 2005 Jun 27.

PMID:
16075307
2.

Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors.

Chen X, Tsiang M, Yu F, Hung M, Jones GS, Zeynalzadegan A, Qi X, Jin H, Kim CU, Swaminathan S, Chen JM.

J Mol Biol. 2008 Jul 11;380(3):504-19. doi: 10.1016/j.jmb.2008.04.054. Epub 2008 May 1.

PMID:
18565342
3.

Modeling HIV-1 integrase complexes based on their hydrodynamic properties.

Podtelezhnikov AA, Gao K, Bushman FD, McCammon JA.

Biopolymers. 2003 Jan;68(1):110-20.

PMID:
12579583
4.

HIV-1 integrase: the next target for AIDS therapy?

d'Angelo J, Mouscadet JF, Desmaële D, Zouhiri F, Leh H.

Pathol Biol (Paris). 2001 Apr;49(3):237-46. Review.

PMID:
11367559
5.

Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain.

Molteni V, Greenwald J, Rhodes D, Hwang Y, Kwiatkowski W, Bushman FD, Siegel JS, Choe S.

Acta Crystallogr D Biol Crystallogr. 2001 Apr;57(Pt 4):536-44.

PMID:
11264582
6.

Structure and function of HIV-1 integrase.

Chiu TK, Davies DR.

Curr Top Med Chem. 2004;4(9):965-77. Review.

PMID:
15134551
7.

A three-dimensional model of the human immunodeficiency virus type 1 integration complex.

Wielens J, Crosby IT, Chalmers DK.

J Comput Aided Mol Des. 2005 May;19(5):301-17.

PMID:
16184433
8.

Characterization and structural analysis of HIV-1 integrase conservation.

Ceccherini-Silberstein F, Malet I, D'Arrigo R, Antinori A, Marcelin AG, Perno CF.

AIDS Rev. 2009 Jan-Mar;11(1):17-29. Review.

PMID:
19290031
9.

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution.

Ding J, Das K, Hsiou Y, Sarafianos SG, Clark AD Jr, Jacobo-Molina A, Tantillo C, Hughes SH, Arnold E.

J Mol Biol. 1998 Dec 11;284(4):1095-111.

PMID:
9837729
10.

HIV integrase: a target for drug discovery.

Lutzke RA, Plasterk RH.

Genes Funct. 1997 Dec;1(5-6):289-307. Review.

PMID:
17366700
11.

A platform for designing HIV integrase inhibitors. Part 2: a two-metal binding model as a potential mechanism of HIV integrase inhibitors.

Kawasuji T, Fuji M, Yoshinaga T, Sato A, Fujiwara T, Kiyama R.

Bioorg Med Chem. 2006 Dec 15;14(24):8420-9. Epub 2006 Sep 26.

PMID:
17005407
13.

Study on the interactions between diketo-acid inhibitors and prototype foamy virus integrase-DNA complex via molecular docking and comparative molecular dynamics simulation methods.

Hu JP, He HQ, Tang DY, Sun GF, Zhang YQ, Fan J, Chang S.

J Biomol Struct Dyn. 2013;31(7):734-47. doi: 10.1080/07391102.2012.709458. Epub 2012 Aug 22.

PMID:
22913375
14.

Dissecting Tn5 transposition using HIV-1 integrase diketoacid inhibitors.

Czyz A, Stillmock KA, Hazuda DJ, Reznikoff WS.

Biochemistry. 2007 Sep 25;46(38):10776-89. Epub 2007 Aug 29.

PMID:
17725323
15.

Docking dinucleotides to HIV-1 integrase carboxyl-terminal domain to find possible DNA binding sites.

Zhu HM, Chen WZ, Wang CX.

Bioorg Med Chem Lett. 2005 Jan 17;15(2):475-7.

PMID:
15603976
16.

HIV integrase as a target for antiviral chemotherapy.

Nair V.

Rev Med Virol. 2002 May-Jun;12(3):179-93. Review.

PMID:
11987143
17.

Changes to the HIV long terminal repeat and to HIV integrase differentially impact HIV integrase assembly, activity, and the binding of strand transfer inhibitors.

Dicker IB, Samanta HK, Li Z, Hong Y, Tian Y, Banville J, Remillard RR, Walker MA, Langley DR, Krystal M.

J Biol Chem. 2007 Oct 26;282(43):31186-96. Epub 2007 Aug 21.

18.

Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes.

Grobler JA, Stillmock K, Hu B, Witmer M, Felock P, Espeseth AS, Wolfe A, Egbertson M, Bourgeois M, Melamed J, Wai JS, Young S, Vacca J, Hazuda DJ.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6661-6. Epub 2002 May 7.

19.

Catalytic domain of human immunodeficiency virus type 1 integrase: identification of a soluble mutant by systematic replacement of hydrophobic residues.

Jenkins TM, Hickman AB, Dyda F, Ghirlando R, Davies DR, Craigie R.

Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6057-61.

20.

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