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Items: 1 to 20 of 66


A compendium of signals and responses triggered by prodeath and prosurvival cytokines.

Gaudet S, Janes KA, Albeck JG, Pace EA, Lauffenburger DA, Sorger PK.

Mol Cell Proteomics. 2005 Oct;4(10):1569-90. Epub 2005 Jul 18.


Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor necrosis-factor-induced apoptosis.

Miller-Jensen K, Janes KA, Wong YL, Griffith LG, Lauffenburger DA.

J Cell Sci. 2006 Sep 15;119(Pt 18):3788-98. Epub 2006 Aug 29.


A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis.

Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB.

Mol Cell Proteomics. 2003 Jul;2(7):463-73. Epub 2003 Jun 26.


A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.

Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB.

Science. 2005 Dec 9;310(5754):1646-53.


Tumor necrosis factor-alpha-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts.

Smith PC, Guerrero J, Tobar N, Cáceres M, González MJ, Martínez J.

J Periodontal Res. 2009 Feb;44(1):73-80. doi: 10.1111/j.1600-0765.2007.01081.x.


RNAi-mediated silencing of insulin receptor substrate 1 (IRS-1) enhances tamoxifen-induced cell death in MCF-7 breast cancer cells.

Cesarone G, Garofalo C, Abrams MT, Igoucheva O, Alexeev V, Yoon K, Surmacz E, Wickstrom E.

J Cell Biochem. 2006 May 15;98(2):440-50.


Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data.

Janes KA, Kelly JR, Gaudet S, Albeck JG, Sorger PK, Lauffenburger DA.

J Comput Biol. 2004;11(4):544-61.


Src homology 2 domain-based high throughput assays for profiling downstream molecules in receptor tyrosine kinase pathways.

Yaoi T, Chamnongpol S, Jiang X, Li X.

Mol Cell Proteomics. 2006 May;5(5):959-68. Epub 2006 Feb 13.


Profiling receptor tyrosine kinase activation by using Ab microarrays.

Nielsen UB, Cardone MH, Sinskey AJ, MacBeath G, Sorger PK.

Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9330-5. Epub 2003 Jul 22.


The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal.

Weigert C, Hennige AM, Brischmann T, Beck A, Moeschel K, Schaüble M, Brodbeck K, Häring HU, Schleicher ED, Lehmann R.

J Biol Chem. 2005 Nov 11;280(45):37393-9. Epub 2005 Aug 29.


Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II.

David-Dufilho M, Millanvoye-Van Brussel E, Topal G, Walch L, Brunet A, Rendu F.

J Biol Chem. 2005 Oct 28;280(43):35999-6006. Epub 2005 Aug 26.


RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas.

Fagiani E, Giardina G, Luzi L, Cesaroni M, Quarto M, Capra M, Germano G, Bono M, Capillo M, Pelicci P, Lanfrancone L.

Cancer Res. 2007 Apr 1;67(7):3064-73.


Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041.

Tong J, Taylor P, Peterman SM, Prakash A, Moran MF.

Mol Cell Proteomics. 2009 Sep;8(9):2131-44. doi: 10.1074/mcp.M900148-MCP200. Epub 2009 Jun 15.


Crosstalk between androgen receptor and epidermal growth factor receptor-signalling pathways: a molecular switch for epithelial cell differentiation.

Léotoing L, Manin M, Monté D, Baron S, Communal Y, Lours C, Veyssière G, Morel L, Beaudoin C.

J Mol Endocrinol. 2007 Aug;39(2):151-62.


Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate.

Santos SD, Verveer PJ, Bastiaens PI.

Nat Cell Biol. 2007 Mar;9(3):324-30. Epub 2007 Feb 18.


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