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Items: 1 to 20 of 83


Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.

Shen B, Singh P, Liu R, Qiu J, Zheng L, Finger LD, Alas S.

Bioessays. 2005 Jul;27(7):717-29. Review.


Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways.

Guo Z, Chavez V, Singh P, Finger LD, Hang H, Hegde ML, Shen B.

J Mol Biol. 2008 Mar 28;377(3):679-90. doi: 10.1016/j.jmb.2007.10.074. Epub 2007 Nov 4.


The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations.

Liu R, Qiu J, Finger LD, Zheng L, Shen B.

Nucleic Acids Res. 2006 Mar 31;34(6):1772-84. Print 2006.


Functional regulation of FEN1 nuclease and its link to cancer.

Zheng L, Jia J, Finger LD, Guo Z, Zer C, Shen B.

Nucleic Acids Res. 2011 Feb;39(3):781-94. doi: 10.1093/nar/gkq884. Epub 2010 Oct 6. Review.


Expression and biochemical characterization of the Plasmodium falciparum DNA repair enzyme, flap endonuclease-1 (PfFEN-1).

Casta LJ, Buguliskis JS, Matsumoto Y, Taraschi TF.

Mol Biochem Parasitol. 2008 Jan;157(1):1-12. Epub 2007 Sep 2.


Substrate recognition and catalysis by flap endonucleases and related enzymes.

Tomlinson CG, Atack JM, Chapados B, Tainer JA, Grasby JA.

Biochem Soc Trans. 2010 Apr;38(2):433-7. doi: 10.1042/BST0380433. Review.


The wonders of flap endonucleases: structure, function, mechanism and regulation.

Finger LD, Atack JM, Tsutakawa S, Classen S, Tainer J, Grasby J, Shen B.

Subcell Biochem. 2012;62:301-26. doi: 10.1007/978-94-007-4572-8_16. Review.


Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks.

Zheng L, Zhou M, Chai Q, Parrish J, Xue D, Patrick SM, Turchi JJ, Yannone SM, Chen D, Shen B.

EMBO Rep. 2005 Jan;6(1):83-9.


Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA.

Wu X, Li J, Li X, Hsieh CL, Burgers PM, Lieber MR.

Nucleic Acids Res. 1996 Jun 1;24(11):2036-43.


The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA.

Sharma S, Sommers JA, Gary RK, Friedrich-Heineken E, Hübscher U, Brosh RM Jr.

Nucleic Acids Res. 2005 Dec 2;33(21):6769-81. Print 2005.


Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability.

Querol-Audí J, Yan C, Xu X, Tsutakawa SE, Tsai MS, Tainer JA, Cooper PK, Nogales E, Ivanov I.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8528-33. doi: 10.1073/pnas.1121116109. Epub 2012 May 14.


Proliferating cell nuclear antigen facilitates excision in long-patch base excision repair.

Gary R, Kim K, Cornelius HL, Park MS, Matsumoto Y.

J Biol Chem. 1999 Feb 12;274(7):4354-63.


Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1.

Hegde ML, Theriot CA, Das A, Hegde PM, Guo Z, Gary RK, Hazra TK, Shen B, Mitra S.

J Biol Chem. 2008 Oct 3;283(40):27028-37. doi: 10.1074/jbc.M802712200. Epub 2008 Jul 28.

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