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Items: 1 to 20 of 125

1.

TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.

Reiser J, Polu KR, Möller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR.

Nat Genet. 2005 Jul;37(7):739-44. Epub 2005 May 27.

2.

Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease.

Sonneveld R, Ferrè S, Hoenderop JG, Dijkman HB, Berden JH, Bindels RJ, Wetzels JF, van der Vlag J, Nijenhuis T.

Am J Pathol. 2013 Apr;182(4):1196-204. doi: 10.1016/j.ajpath.2012.12.011. Epub 2013 Feb 4.

PMID:
23385000
3.

A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis.

Winn MP, Conlon PJ, Lynn KL, Farrington MK, Creazzo T, Hawkins AF, Daskalakis N, Kwan SY, Ebersviller S, Burchette JL, Pericak-Vance MA, Howell DN, Vance JM, Rosenberg PB.

Science. 2005 Jun 17;308(5729):1801-4. Epub 2005 May 5.

4.

Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease.

Kistler AD, Singh G, Altintas MM, Yu H, Fernandez IC, Gu C, Wilson C, Srivastava SK, Dietrich A, Walz K, Kerjaschki D, Ruiz P, Dryer S, Sever S, Dinda AK, Faul C, Reiser J.

J Biol Chem. 2013 Dec 20;288(51):36598-609. doi: 10.1074/jbc.M113.488122. Epub 2013 Nov 5.

5.

TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology.

Dryer SE, Reiser J.

Am J Physiol Renal Physiol. 2010 Oct;299(4):F689-701. doi: 10.1152/ajprenal.00298.2010. Epub 2010 Aug 4. Review.

6.

A new TRP to kidney disease.

Gudermann T.

Nat Genet. 2005 Jul;37(7):663-4. No abstract available.

PMID:
15990884
7.

New TRPC6 gain-of-function mutation in a non-consanguineous Dutch family with late-onset focal segmental glomerulosclerosis.

Hofstra JM, Lainez S, van Kuijk WH, Schoots J, Baltissen MP, Hoefsloot LH, Knoers NV, Berden JH, Bindels RJ, van der Vlag J, Hoenderop JG, Wetzels JF, Nijenhuis T.

Nephrol Dial Transplant. 2013 Jul;28(7):1830-8. doi: 10.1093/ndt/gfs572. Epub 2013 Jan 4.

PMID:
23291369
8.

Regulation of TRPC6 ion channels in podocytes - Implications for focal segmental glomerulosclerosis and acquired forms of proteinuric diseases.

Szabó T, Ambrus L, Zákány N, Balla G, Bíró T.

Acta Physiol Hung. 2015 Sep;102(3):241-51. doi: 10.1556/036.102.2015.3.2. Review.

PMID:
26551740
9.

TRPC6 channel as an emerging determinant of the podocyte injury susceptibility in kidney diseases.

Ilatovskaya DV, Staruschenko A.

Am J Physiol Renal Physiol. 2015 Sep 1;309(5):F393-7. doi: 10.1152/ajprenal.00186.2015. Epub 2015 Jun 17. Review.

10.

TRPC6 and FSGS: the latest TRP channelopathy.

Mukerji N, Damodaran TV, Winn MP.

Biochim Biophys Acta. 2007 Aug;1772(8):859-68. Epub 2007 Mar 20. Review.

11.

TRPC6 - a new podocyte gene involved in focal segmental glomerulosclerosis.

Kriz W.

Trends Mol Med. 2005 Dec;11(12):527-30. Epub 2005 Nov 11. Review.

PMID:
16290061
12.

Gq signaling causes glomerular injury by activating TRPC6.

Wang L, Jirka G, Rosenberg PB, Buckley AF, Gomez JA, Fields TA, Winn MP, Spurney RF.

J Clin Invest. 2015 May;125(5):1913-26. doi: 10.1172/JCI76767. Epub 2015 Apr 6.

13.

Sensitizing the Slit Diaphragm with TRPC6 ion channels.

Möller CC, Flesche J, Reiser J.

J Am Soc Nephrol. 2009 May;20(5):950-3. doi: 10.1681/ASN.2008030329. Epub 2008 Sep 10.

14.

Genetic Interactions Between TRPC6 and NPHS1 Variants Affect Posttransplant Risk of Recurrent Focal Segmental Glomerulosclerosis.

Sun ZJ, Ng KH, Liao P, Zhang Y, Ng JL, Liu ID, Tan PH, Chong SS, Chan YH, Liu J, Davila S, Heng CK, Jordan SC, Soong TW, Yap HK.

Am J Transplant. 2015 Dec;15(12):3229-38. doi: 10.1111/ajt.13378. Epub 2015 Jul 3.

15.

TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription.

Schlöndorff J, Del Camino D, Carrasquillo R, Lacey V, Pollak MR.

Am J Physiol Cell Physiol. 2009 Mar;296(3):C558-69. doi: 10.1152/ajpcell.00077.2008. Epub 2009 Jan 7.

16.

TRPC6 in glomerular health and disease: what we know and what we believe.

Schlöndorff JS, Pollak MR.

Semin Cell Dev Biol. 2006 Dec;17(6):667-74. Epub 2006 Nov 20. Review.

17.

Genetic kidney diseases disclose the pathogenesis of proteinuria.

Jalanko H, Patrakka J, Tryggvason K, Holmberg C.

Ann Med. 2001 Nov;33(8):526-33. Review.

PMID:
11730159
18.

Developmental changes in the expression and function of TRPC6 channels related the F-actin organization during differentiation in podocytes.

Liu Z, Yang J, Zhang X, Xu P, Zhang T, Yang Z.

Cell Calcium. 2015 Dec;58(6):541-8. doi: 10.1016/j.ceca.2015.09.001. Epub 2015 Sep 3.

PMID:
26363733
19.

MYO1E mutations and childhood familial focal segmental glomerulosclerosis.

Mele C, Iatropoulos P, Donadelli R, Calabria A, Maranta R, Cassis P, Buelli S, Tomasoni S, Piras R, Krendel M, Bettoni S, Morigi M, Delledonne M, Pecoraro C, Abbate I, Capobianchi MR, Hildebrandt F, Otto E, Schaefer F, Macciardi F, Ozaltin F, Emre S, Ibsirlioglu T, Benigni A, Remuzzi G, Noris M; PodoNet Consortium.

N Engl J Med. 2011 Jul 28;365(4):295-306. doi: 10.1056/NEJMoa1101273. Epub 2011 Jul 14.

20.

Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol.

Anderson M, Kim EY, Hagmann H, Benzing T, Dryer SE.

Am J Physiol Cell Physiol. 2013 Aug 1;305(3):C276-89. doi: 10.1152/ajpcell.00095.2013. Epub 2013 May 8.

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