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Items: 1 to 20 of 159

1.

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.

Semënov M, Tamai K, He X.

J Biol Chem. 2005 Jul 22;280(29):26770-5. Epub 2005 May 20.

2.

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling.

Li X, Zhang Y, Kang H, Liu W, Liu P, Zhang J, Harris SE, Wu D.

J Biol Chem. 2005 May 20;280(20):19883-7. Epub 2005 Mar 18.

3.

LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST.

Semenov MV, He X.

J Biol Chem. 2006 Dec 15;281(50):38276-84. Epub 2006 Oct 19.

4.

Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.

Ellies DL, Viviano B, McCarthy J, Rey JP, Itasaki N, Saunders S, Krumlauf R.

J Bone Miner Res. 2006 Nov;21(11):1738-49.

5.

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.

Semënov MV, Tamai K, Brott BK, Kühl M, Sokol S, He X.

Curr Biol. 2001 Jun 26;11(12):951-61.

6.

Expression, purification and functional characterization of Wnt signaling co-receptors LRP5 and LRP6.

Fleury D, Vayssiere B, Touitou R, Gillard C, Lebhar H, Rawadi G, Mollat P.

Protein Expr Purif. 2010 Mar;70(1):39-47. doi: 10.1016/j.pep.2009.08.012. Epub 2009 Aug 27.

PMID:
19716419
7.

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.

Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C.

Nature. 2001 May 17;411(6835):321-5.

PMID:
11357136
8.

Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling.

Mao B, Niehrs C.

Gene. 2003 Jan 2;302(1-2):179-83.

PMID:
12527209
9.

[Recent topics on bone remodeling].

Shinoda Y, Ogata N, Chung UI, Kawaguchi H.

Clin Calcium. 2004 Jan;14(1):70-4. Review. Japanese.

PMID:
15576958
10.

The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations.

Balemans W, Piters E, Cleiren E, Ai M, Van Wesenbeeck L, Warman ML, Van Hul W.

Calcif Tissue Int. 2008 Jun;82(6):445-53. doi: 10.1007/s00223-008-9130-9.

PMID:
18521528
11.

Analysis of association of LRP5, LRP6, SOST, DKK1, and CTNNB1 genes with bone mineral density in a Slovenian population.

Mencej-Bedrac S, Prezelj J, Kocjan T, Komadina R, Marc J.

Calcif Tissue Int. 2009 Dec;85(6):501-6. doi: 10.1007/s00223-009-9306-y. Epub 2009 Nov 7.

PMID:
19898734
12.

LDL-receptor-related proteins in Wnt signal transduction.

Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X.

Nature. 2000 Sep 28;407(6803):530-5.

PMID:
11029007
13.

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling.

Holmen SL, Salic A, Zylstra CR, Kirschner MW, Williams BO.

J Biol Chem. 2002 Sep 20;277(38):34727-35. Epub 2002 Jul 16.

14.

Function and biological roles of the Dickkopf family of Wnt modulators.

Niehrs C.

Oncogene. 2006 Dec 4;25(57):7469-81. Review.

PMID:
17143291
15.

[Wnt signaling and bone metabolism].

Asaba H, Sakai J.

Clin Calcium. 2005 May;15(5):813-8. Japanese.

PMID:
15876744
16.

Wnt signalling: antagonistic Dickkopfs.

Zorn AM.

Curr Biol. 2001 Aug 7;11(15):R592-5.

17.

Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo.

Choi HY, Dieckmann M, Herz J, Niemeier A.

PLoS One. 2009 Nov 20;4(11):e7930. doi: 10.1371/journal.pone.0007930.

18.

A model for signaling specificity of Wnt/Frizzled combinations through co-receptor recruitment.

Verkaar F, Zaman GJ.

FEBS Lett. 2010 Sep 24;584(18):3850-4. doi: 10.1016/j.febslet.2010.08.030. Epub 2010 Aug 25.

19.

Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.

Nam JS, Turcotte TJ, Smith PF, Choi S, Yoon JK.

J Biol Chem. 2006 May 12;281(19):13247-57. Epub 2006 Mar 16.

20.

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.

Bourhis E, Tam C, Franke Y, Bazan JF, Ernst J, Hwang J, Costa M, Cochran AG, Hannoush RN.

J Biol Chem. 2010 Mar 19;285(12):9172-9. doi: 10.1074/jbc.M109.092130. Epub 2010 Jan 21.

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