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Items: 1 to 20 of 256

1.
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Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.

Das I, Craig C, Funahashi Y, Jung KM, Kim TW, Byers R, Weng AP, Kutok JL, Aster JC, Kitajewski J.

J Biol Chem. 2004 Jul 16;279(29):30771-80. Epub 2004 May 3.

4.

Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.

Li G, Percontino L, Sun Q, Qazi AS, Frederikse PH.

Mol Vis. 2003 May 1;9:179-83.

5.

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1.

Zhang Z, Nadeau P, Song W, Donoviel D, Yuan M, Bernstein A, Yankner BA.

Nat Cell Biol. 2000 Jul;2(7):463-5. No abstract available.

PMID:
10878814
6.
7.

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.

Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT.

J Biol Chem. 2003 Nov 28;278(48):47370-5. Epub 2003 Sep 5.

8.

The role of presenilin 1 during somite segmentation.

Koizumi K, Nakajima M, Yuasa S, Saga Y, Sakai T, Kuriyama T, Shirasawa T, Koseki H.

Development. 2001 Apr;128(8):1391-402.

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Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.

Zhang L, Lee J, Song L, Sun X, Shen J, Terracina G, Parker EM.

Biochemistry. 2005 Mar 22;44(11):4450-7.

PMID:
15766275
12.

Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.

Li J, Fici GJ, Mao CA, Myers RL, Shuang R, Donoho GP, Pauley AM, Himes CS, Qin W, Kola I, Merchant KM, Nye JS.

J Biol Chem. 2003 Aug 29;278(35):33445-9. Epub 2003 Jun 18.

13.

Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation.

Feller J, Schneider A, Schuster-Gossler K, Gossler A.

Genes Dev. 2008 Aug 15;22(16):2166-71. doi: 10.1101/gad.480408.

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The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite.

Oginuma M, Takahashi Y, Kitajima S, Kiso M, Kanno J, Kimura A, Saga Y.

Development. 2010 May;137(9):1515-22. doi: 10.1242/dev.044545. Epub 2010 Mar 24.

16.

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation.

Herreman A, Van Gassen G, Bentahir M, Nyabi O, Craessaerts K, Mueller U, Annaert W, De Strooper B.

J Cell Sci. 2003 Mar 15;116(Pt 6):1127-36.

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A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex.

Lee SF, Shah S, Yu C, Wigley WC, Li H, Lim M, Pedersen K, Han W, Thomas P, Lundkvist J, Hao YH, Yu G.

J Biol Chem. 2004 Feb 6;279(6):4144-52. Epub 2003 Nov 19.

20.

Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors.

Leimeister C, Dale K, Fischer A, Klamt B, Hrabe de Angelis M, Radtke F, McGrew MJ, Pourquié O, Gessler M.

Dev Biol. 2000 Nov 1;227(1):91-103.

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