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Items: 1 to 20 of 130

1.

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1.

El-Khamisy SF, Saifi GM, Weinfeld M, Johansson F, Helleday T, Lupski JR, Caldecott KW.

Nature. 2005 Mar 3;434(7029):108-13.

PMID:
15744309
2.

Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes.

Miao ZH, Agama K, Sordet O, Povirk L, Kohn KW, Pommier Y.

DNA Repair (Amst). 2006 Dec 9;5(12):1489-94. Epub 2006 Aug 28.

PMID:
16935573
3.

DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1.

el-Khamisy SF, Caldecott KW.

Neuroscience. 2007 Apr 14;145(4):1260-6. Epub 2006 Oct 11. Review.

PMID:
17045754
4.

TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo.

Katyal S, el-Khamisy SF, Russell HR, Li Y, Ju L, Caldecott KW, McKinnon PJ.

EMBO J. 2007 Nov 14;26(22):4720-31. Epub 2007 Oct 4.

5.

TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks.

El-Khamisy SF, Hartsuiker E, Caldecott KW.

DNA Repair (Amst). 2007 Oct 1;6(10):1485-95. Epub 2007 Jun 28.

PMID:
17600775
6.

Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin.

El-Khamisy SF, Katyal S, Patel P, Ju L, McKinnon PJ, Caldecott KW.

DNA Repair (Amst). 2009 Jun 4;8(6):760-6. doi: 10.1016/j.dnarep.2009.02.002. Epub 2009 Mar 19.

7.

Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?

Hirano R, Interthal H, Huang C, Nakamura T, Deguchi K, Choi K, Bhattacharjee MB, Arimura K, Umehara F, Izumo S, Northrop JL, Salih MA, Inoue K, Armstrong DL, Champoux JJ, Takashima H, Boerkoel CF.

EMBO J. 2007 Nov 14;26(22):4732-43. Epub 2007 Oct 18.

8.

Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavage.

Comeaux EQ, Cuya SM, Kojima K, Jafari N, Wanzeck KC, Mobley JA, Bjornsti MA, van Waardenburg RC.

J Biol Chem. 2015 Mar 6;290(10):6203-14. doi: 10.1074/jbc.M114.635284. Epub 2015 Jan 21.

9.

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

Zeng Z, Sharma A, Ju L, Murai J, Umans L, Vermeire L, Pommier Y, Takeda S, Huylebroeck D, Caldecott KW, El-Khamisy SF.

Nucleic Acids Res. 2012 Sep 1;40(17):8371-80. Epub 2012 Jun 26.

10.

Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.

Zhou T, Akopiants K, Mohapatra S, Lin PS, Valerie K, Ramsden DA, Lees-Miller SP, Povirk LF.

DNA Repair (Amst). 2009 Aug 6;8(8):901-11. doi: 10.1016/j.dnarep.2009.05.003. Epub 2009 Jun 7.

11.

Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1).

Zhou T, Lee JW, Tatavarthi H, Lupski JR, Valerie K, Povirk LF.

Nucleic Acids Res. 2005 Jan 12;33(1):289-97. Print 2005.

12.

In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation.

Hawkins AJ, Subler MA, Akopiants K, Wiley JL, Taylor SM, Rice AC, Windle JJ, Valerie K, Povirk LF.

DNA Repair (Amst). 2009 May 1;8(5):654-63. doi: 10.1016/j.dnarep.2008.12.012. Epub 2009 Feb 10.

13.

Spinocerebellar ataxia with axonal neuropathy.

Walton C, Interthal H, Hirano R, Salih MA, Takashima H, Boerkoel CF.

Adv Exp Med Biol. 2010;685:75-83. Review.

PMID:
20687496
14.

Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions.

Plo I, Liao ZY, Barceló JM, Kohlhagen G, Caldecott KW, Weinfeld M, Pommier Y.

DNA Repair (Amst). 2003 Oct 7;2(10):1087-100.

PMID:
13679147
15.

Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy.

Takashima H, Boerkoel CF, John J, Saifi GM, Salih MA, Armstrong D, Mao Y, Quiocho FA, Roa BB, Nakagawa M, Stockton DW, Lupski JR.

Nat Genet. 2002 Oct;32(2):267-72. Epub 2002 Sep 16.

PMID:
12244316
16.

TDP1-dependent DNA single-strand break repair and neurodegeneration.

El-Khamisy SF, Caldecott KW.

Mutagenesis. 2006 Jul;21(4):219-24. Epub 2006 Jun 14. Review.

PMID:
16775218
17.

SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity.

Interthal H, Chen HJ, Kehl-Fie TE, Zotzmann J, Leppard JB, Champoux JJ.

EMBO J. 2005 Jun 15;24(12):2224-33. Epub 2005 May 26.

18.

SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair.

Hudson JJ, Chiang SC, Wells OS, Rookyard C, El-Khamisy SF.

Nat Commun. 2012 Mar 13;3:733. doi: 10.1038/ncomms1739.

19.

A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage.

Cortes Ledesma F, El Khamisy SF, Zuma MC, Osborn K, Caldecott KW.

Nature. 2009 Oct 1;461(7264):674-8. doi: 10.1038/nature08444.

PMID:
19794497
20.

ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells.

Alagoz M, Chiang SC, Sharma A, El-Khamisy SF.

PLoS One. 2013 Apr 23;8(4):e58239. doi: 10.1371/journal.pone.0058239. Print 2013.

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