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Items: 1 to 20 of 297

1.

Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics.

Espeseth AS, Xu M, Huang Q, Coburn CA, Jones KL, Ferrer M, Zuck PD, Strulovici B, Price EA, Wu G, Wolfe AL, Lineberger JE, Sardana M, Tugusheva K, Pietrak BL, Crouthamel MC, Lai MT, Dodson EC, Bazzo R, Shi XP, Simon AJ, Li Y, Hazuda DJ.

J Biol Chem. 2005 May 6;280(18):17792-7. Epub 2005 Feb 25.

2.

Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.

Shi XP, Tugusheva K, Bruce JE, Lucka A, Wu GX, Chen-Dodson E, Price E, Li Y, Xu M, Huang Q, Sardana MK, Hazuda DJ.

J Biol Chem. 2003 Jun 6;278(23):21286-94. Epub 2003 Mar 27.

3.

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.

Farzan M, Schnitzler CE, Vasilieva N, Leung D, Choe H.

Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9712-7.

4.

The beta-secretase, BACE: a prime drug target for Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2001 Oct;17(2):157-70. Review.

PMID:
11816789
5.

BACE1: the beta-secretase enzyme in Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2004;23(1-2):105-14. Review.

PMID:
15126696
6.
7.

Beta-secretase (BACE) as a drug target for Alzheimer's disease.

Vassar R.

Adv Drug Deliv Rev. 2002 Dec 7;54(12):1589-602. Review.

PMID:
12453676
8.

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.

J Pharmacol Exp Ther. 2008 Mar;324(3):957-69. Epub 2007 Dec 21.

9.

RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.

Désiré L, Bourdin J, Loiseau N, Peillon H, Picard V, De Oliveira C, Bachelot F, Leblond B, Taverne T, Beausoleil E, Lacombe S, Drouin D, Schweighoffer F.

J Biol Chem. 2005 Nov 11;280(45):37516-25. Epub 2005 Sep 8.

10.

PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein.

Xie J, Guo Q.

J Biol Chem. 2005 Apr 8;280(14):13824-32. Epub 2005 Jan 25.

11.
12.
13.

Positive-negative epitope-tagging of beta amyloid precursor protein to identify inhibitors of A beta processing.

Seiffert D, Mitchell T, Stern AM, Roach A, Zhan Y, Grzanna R.

Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):115-26.

PMID:
11113538
14.

Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.

Shi XP, Tugusheva K, Bruce JE, Lucka A, Chen-Dodson E, Hu B, Wu GX, Price E, Register RB, Lineberger J, Miller R, Tang MJ, Espeseth A, Kahana J, Wolfe A, Crouthamel MC, Sankaranarayanan S, Simon A, Chen L, Lai MT, Pietrak B, DiMuzio J, Li Y, Xu M, Huang Q, Garsky V, Sardana MK, Hazuda DJ.

J Alzheimers Dis. 2005 Apr;7(2):139-48; discussion 173-80.

PMID:
15851852
15.

Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.

Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N.

Neurobiol Dis. 2005 Nov;20(2):625-37. Epub 2005 Jun 3.

PMID:
15936948
16.

Human beta-secretase (BACE) and BACE inhibitors: progress report.

John V.

Curr Top Med Chem. 2006;6(6):569-78. Review.

PMID:
16712492
17.

Effects of peptides derived from BACE1 catalytic domain on APP processing.

Yeon SW, Jeon YJ, Hwang EM, Kim TY.

Peptides. 2007 Apr;28(4):838-44. Epub 2007 Jan 19.

PMID:
17293005
18.
20.

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.

Hussain I, Hawkins J, Harrison D, Hille C, Wayne G, Cutler L, Buck T, Walter D, Demont E, Howes C, Naylor A, Jeffrey P, Gonzalez MI, Dingwall C, Michel A, Redshaw S, Davis JB.

J Neurochem. 2007 Feb;100(3):802-9.

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