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Items: 1 to 20 of 150

1.

Presenilin-1-dependent transcriptome changes.

Mirnics K, Korade Z, Arion D, Lazarov O, Unger T, Macioce M, Sabatini M, Terrano D, Douglass KC, Schor NF, Sisodia SS.

J Neurosci. 2005 Feb 9;25(6):1571-8.

2.

Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway.

Jaffar S, Counts SE, Ma SY, Dadko E, Gordon MN, Morgan D, Mufson EJ.

Exp Neurol. 2001 Aug;170(2):227-43.

PMID:
11476589
3.

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS.

Neuron. 1997 Oct;19(4):939-45.

4.

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

Saura CA, Chen G, Malkani S, Choi SY, Takahashi RH, Zhang D, Gouras GK, Kirkwood A, Morris RG, Shen J.

J Neurosci. 2005 Jul 20;25(29):6755-64.

5.

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.

Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, Copeland NG, Jenkins NA, Price DL, Younkin SG, Sisodia SS.

Neuron. 1996 Nov;17(5):1005-13.

6.

The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.

Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA.

Exp Neurol. 2004 Aug;188(2):224-37.

PMID:
15246822
7.
8.

APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.

Jankowsky JL, Slunt HH, Gonzales V, Jenkins NA, Copeland NG, Borchelt DR.

Neurobiol Aging. 2004 Aug;25(7):885-92.

PMID:
15212842
9.

Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice.

Dickey CA, Loring JF, Montgomery J, Gordon MN, Eastman PS, Morgan D.

J Neurosci. 2003 Jun 15;23(12):5219-26.

10.

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.

Lee MK, Borchelt DR, Kim G, Thinakaran G, Slunt HH, Ratovitski T, Martin LJ, Kittur A, Gandy S, Levey AI, Jenkins N, Copeland N, Price DL, Sisodia SS.

Nat Med. 1997 Jul;3(7):756-60.

PMID:
9212102
11.

Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.

Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A.

J Biol Chem. 2008 Jun 13;283(24):16488-96. doi: 10.1074/jbc.M801279200. Epub 2008 Apr 21.

12.

Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.

Berezovska O, Lleo A, Herl LD, Frosch MP, Stern EA, Bacskai BJ, Hyman BT.

J Neurosci. 2005 Mar 16;25(11):3009-17.

13.

Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions.

Ramirez MJ, Heslop KE, Francis PT, Rattray M.

Brain Res. 2001 Jul 13;907(1-2):222-32.

PMID:
11430905
14.

Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice.

Dickey CA, Gordon MN, Mason JE, Wilson NJ, Diamond DM, Guzowski JF, Morgan D.

J Neurochem. 2004 Jan;88(2):434-42.

16.

True and false discovery in DNA microarray experiments: transcriptome changes in the hippocampus of presenilin 1 mutant mice.

Unger T, Korade Z, Lazarov O, Terrano D, Sisodia SS, Mirnics K.

Methods. 2005 Nov;37(3):261-73.

PMID:
16308155
17.

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice.

Yu H, Saura CA, Choi SY, Sun LD, Yang X, Handler M, Kawarabayashi T, Younkin L, Fedeles B, Wilson MA, Younkin S, Kandel ER, Kirkwood A, Shen J.

Neuron. 2001 Sep 13;31(5):713-26.

18.
19.

Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.

Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T.

J Neurosci. 2007 Nov 28;27(48):13092-7.

20.

Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.

Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G.

Nat Cell Biol. 2000 Dec;2(12):863-70.

PMID:
11146649

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