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Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation.

Kuzmichev A, Margueron R, Vaquero A, Preissner TS, Scher M, Kirmizis A, Ouyang X, Brockdorff N, Abate-Shen C, Farnham P, Reinberg D.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1859-64. Epub 2005 Jan 31.


Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer.

Hoffmann MJ, Engers R, Florl AR, Otte AP, Muller M, Schulz WA.

Cancer Biol Ther. 2007 Sep;6(9):1403-12.


Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.

Kirmizis A, Bartley SM, Kuzmichev A, Margueron R, Reinberg D, Green R, Farnham PJ.

Genes Dev. 2004 Jul 1;18(13):1592-605.


Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells.

Fiskus W, Pranpat M, Balasis M, Herger B, Rao R, Chinnaiyan A, Atadja P, Bhalla K.

Mol Cancer Ther. 2006 Dec;5(12):3096-104.


Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3.

Kuzmichev A, Jenuwein T, Tempst P, Reinberg D.

Mol Cell. 2004 Apr 23;14(2):183-93.


The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.

Aoki R, Chiba T, Miyagi S, Negishi M, Konuma T, Taniguchi H, Ogawa M, Yokosuka O, Iwama A.

J Hepatol. 2010 Jun;52(6):854-63. doi: 10.1016/j.jhep.2010.01.027. Epub 2010 Mar 24.


Polycomb repressive complex 2 is required for MLL-AF9 leukemia.

Neff T, Sinha AU, Kluk MJ, Zhu N, Khattab MH, Stein L, Xie H, Orkin SH, Armstrong SA.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5028-33. doi: 10.1073/pnas.1202258109. Epub 2012 Mar 6.


CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells.

Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC.

Nat Cell Biol. 2011 Jan;13(1):87-94. doi: 10.1038/ncb2139. Epub 2010 Dec 5.


Polycomb group protein-associated chromatin is reproduced in post-mitotic G1 phase and is required for S phase progression.

Aoto T, Saitoh N, Sakamoto Y, Watanabe S, Nakao M.

J Biol Chem. 2008 Jul 4;283(27):18905-15. doi: 10.1074/jbc.M709322200. Epub 2008 May 2.


Repression of E-cadherin by the polycomb group protein EZH2 in cancer.

Cao Q, Yu J, Dhanasekaran SM, Kim JH, Mani RS, Tomlins SA, Mehra R, Laxman B, Cao X, Yu J, Kleer CG, Varambally S, Chinnaiyan AM.

Oncogene. 2008 Dec 11;27(58):7274-84. doi: 10.1038/onc.2008.333. Epub 2008 Sep 22.


Substrate preferences of the EZH2 histone methyltransferase complex.

Martin C, Cao R, Zhang Y.

J Biol Chem. 2006 Mar 31;281(13):8365-70. Epub 2006 Jan 23.


Jarid2 and PRC2, partners in regulating gene expression.

Li G, Margueron R, Ku M, Chambon P, Bernstein BE, Reinberg D.

Genes Dev. 2010 Feb 15;24(4):368-80. doi: 10.1101/gad.1886410. Epub 2010 Feb 1.


Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer.

Berezovska OP, Glinskii AB, Yang Z, Li XM, Hoffman RM, Glinsky GV.

Cell Cycle. 2006 Aug;5(16):1886-901. Epub 2006 Aug 15.


Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.

Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D.

Genes Dev. 2002 Nov 15;16(22):2893-905.


Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.

Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K.

EMBO J. 2004 Oct 13;23(20):4061-71. Epub 2004 Sep 23.


The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation.

Kalantry S, Mills KC, Yee D, Otte AP, Panning B, Magnuson T.

Nat Cell Biol. 2006 Feb;8(2):195-202. Epub 2006 Jan 15.


Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features.

van Leenders GJ, Dukers D, Hessels D, van den Kieboom SW, Hulsbergen CA, Witjes JA, Otte AP, Meijer CJ, Raaphorst FM.

Eur Urol. 2007 Aug;52(2):455-63. Epub 2006 Nov 17.


Role of histone H3 lysine 27 methylation in Polycomb-group silencing.

Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y.

Science. 2002 Nov 1;298(5595):1039-43. Epub 2002 Sep 26.

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