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Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance.

Marriott HM, Bingle CD, Read RC, Braley KE, Kroemer G, Hellewell PG, Craig RW, Whyte MK, Dockrell DH.

J Clin Invest. 2005 Feb;115(2):359-68.


A small hairpin RNA targeting myeloid cell leukemia-1 enhances apoptosis in host macrophages infected with Mycobacterium tuberculosis.

Wang FY, Zhang YQ, Wang XM, Wang C, Wang XF, Wu JD, Wu F, Zhang WJ, Zhang L.

J Microbiol. 2016 Apr;54(4):330-7. doi: 10.1007/s12275-016-5627-5. Epub 2016 Apr 1.


Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection.

Marriott HM, Ali F, Read RC, Mitchell TJ, Whyte MK, Dockrell DH.

FASEB J. 2004 Jul;18(10):1126-8. Epub 2004 May 7.


Leishmania donovani Exploits Myeloid Cell Leukemia 1 (MCL-1) Protein to Prevent Mitochondria-dependent Host Cell Apoptosis.

Giri J, Srivastav S, Basu M, Palit S, Gupta P, Ukil A.

J Biol Chem. 2016 Feb 12;291(7):3496-507. doi: 10.1074/jbc.M115.672873. Epub 2015 Dec 15.


Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival.

Liu H, Ma Y, Cole SM, Zander C, Chen KH, Karras J, Pope RM.

Blood. 2003 Jul 1;102(1):344-52. Epub 2003 Mar 13.


The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages.

Dzhagalov I, St John A, He YW.

Blood. 2007 Feb 15;109(4):1620-6. Epub 2006 Oct 24.


Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae.

Bewley MA, Pham TK, Marriott HM, Noirel J, Chu HP, Ow SY, Ryazanov AG, Read RC, Whyte MK, Chain B, Wright PC, Dockrell DH.

Mol Cell Proteomics. 2011 Jun;10(6):M111.008193. doi: 10.1074/mcp.M111.008193. Epub 2011 Apr 7.


Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to HIV-Vpr-induced apoptosis.

Busca A, Saxena M, Kumar A.

J Biol Chem. 2012 Apr 27;287(18):15118-33. doi: 10.1074/jbc.M111.312660. Epub 2012 Mar 8.


A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.

Bewley MA, Marriott HM, Tulone C, Francis SE, Mitchell TJ, Read RC, Chain B, Kroemer G, Whyte MK, Dockrell DH.

PLoS Pathog. 2011 Jan 27;7(1):e1001262. doi: 10.1371/journal.ppat.1001262.


Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia.

Marriott HM, Hellewell PG, Cross SS, Ince PG, Whyte MK, Dockrell DH.

J Immunol. 2006 Nov 1;177(9):6480-8.


Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death.

Bingle CD, Craig RW, Swales BM, Singleton V, Zhou P, Whyte MK.

J Biol Chem. 2000 Jul 21;275(29):22136-46.


The role of the macrophage in lung disease mediated by bacteria.

Marriott HM, Dockrell DH.

Exp Lung Res. 2007 Dec;33(10):493-505. Review.


Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung.

Lucas CD, Dorward DA, Tait MA, Fox S, Marwick JA, Allen KC, Robb CT, Hirani N, Haslett C, Duffin R, Rossi AG.

Mucosal Immunol. 2014 Jul;7(4):857-68. doi: 10.1038/mi.2013.102. Epub 2013 Nov 27.


MCL-1 inhibits BAX in the absence of MCL-1/BAX Interaction.

Germain M, Milburn J, Duronio V.

J Biol Chem. 2008 Mar 7;283(10):6384-92. Epub 2007 Dec 18.


Human oral cancers have altered expression of Bcl-2 family members and increased expression of the anti-apoptotic splice variant of Mcl-1.

Mallick S, Patil R, Gyanchandani R, Pawar S, Palve V, Kannan S, Pathak KA, Choudhary M, Teni TR.

J Pathol. 2009 Feb;217(3):398-407. doi: 10.1002/path.2459.


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