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Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage.

Kobayashi M, Squires GR, Mousa A, Tanzer M, Zukor DJ, Antoniou J, Feige U, Poole AR.

Arthritis Rheum. 2005 Jan;52(1):128-35.


Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: relationship to mediators of systemic and local inflammation.

Fraser A, Fearon U, Billinghurst RC, Ionescu M, Reece R, Barwick T, Emery P, Poole AR, Veale DJ.

Arthritis Rheum. 2003 Nov;48(11):3085-95.


Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1).

Dahlberg L, Billinghurst RC, Manner P, Nelson F, Webb G, Ionescu M, Reiner A, Tanzer M, Zukor D, Chen J, van Wart HE, Poole AR.

Arthritis Rheum. 2000 Mar;43(3):673-82.


Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.

Little CB, Flannery CR, Hughes CE, Mort JS, Roughley PJ, Dent C, Caterson B.

Biochem J. 1999 Nov 15;344 Pt 1:61-8.


Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis.

Shlopov BV, Gumanovskaya ML, Hasty KA.

Arthritis Rheum. 2000 Jan;43(1):195-205.


Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage.

Sui Y, Lee JH, DiMicco MA, Vanderploeg EJ, Blake SM, Hung HH, Plaas AH, James IE, Song XY, Lark MW, Grodzinsky AJ.

Arthritis Rheum. 2009 Oct;60(10):2985-96. doi: 10.1002/art.24857.


Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines.

Patwari P, Cook MN, DiMicco MA, Blake SM, James IE, Kumar S, Cole AA, Lark MW, Grodzinsky AJ.

Arthritis Rheum. 2003 May;48(5):1292-301.


Activation of cartilage matrix metalloproteinases by activated protein C.

Jackson MT, Smith MM, Smith SM, Jackson CJ, Xue M, Little CB.

Arthritis Rheum. 2009 Mar;60(3):780-91. doi: 10.1002/art.24303.


Efficacy and mechanism of action of KHBJ-9B, a new herbal medicine, and its major compound triterpenoids in human cartilage culture and in a rabbit model of collagenase-induced osteoarthritis.

Huh JE, Baek YH, Ryu SR, Lee JD, Choi DY, Park DS.

Int Immunopharmacol. 2009 Feb;9(2):230-40. doi: 10.1016/j.intimp.2008.11.016. Epub 2008 Dec 17.


The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytes.

Kim HA, Cho ML, Choi HY, Yoon CS, Jhun JY, Oh HJ, Kim HY.

Arthritis Rheum. 2006 Jul;54(7):2152-63.


Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage.

Yasuda T, Tchetina E, Ohsawa K, Roughley PJ, Wu W, Mousa A, Ionescu M, Pidoux I, Poole AR.

Matrix Biol. 2006 Sep;25(7):419-29. Epub 2006 Jun 30.


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