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Antibody-based profiling of the phosphoinositide 3-kinase pathway in clinical prostate cancer.

Thomas GV, Horvath S, Smith BL, Crosby K, Lebel LA, Schrage M, Said J, De Kernion J, Reiter RE, Sawyers CL.

Clin Cancer Res. 2004 Dec 15;10(24):8351-6.


The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway.

Wu X, Senechal K, Neshat MS, Whang YE, Sawyers CL.

Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15587-91.


PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase.

Leenders F, Möpert K, Schmiedeknecht A, Santel A, Czauderna F, Aleku M, Penschuck S, Dames S, Sternberger M, Röhl T, Wellmann A, Arnold W, Giese K, Kaufmann J, Klippel A.

EMBO J. 2004 Aug 18;23(16):3303-13. Epub 2004 Jul 29.


The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells.

Asano T, Yao Y, Zhu J, Li D, Abbruzzese JL, Reddy SA.

Oncogene. 2004 Nov 11;23(53):8571-80. Erratum in: Oncogene. 2005 Jun 16;24(26)4320.


Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo.

Choe G, Horvath S, Cloughesy TF, Crosby K, Seligson D, Palotie A, Inge L, Smith BL, Sawyers CL, Mischel PS.

Cancer Res. 2003 Jun 1;63(11):2742-6.


Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization.

Motti ML, Califano D, Troncone G, De Marco C, Migliaccio I, Palmieri E, Pezzullo L, Palombini L, Fusco A, Viglietto G.

Am J Pathol. 2005 Mar;166(3):737-49.


Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells.

St-Germain ME, Gagnon V, Mathieu I, Parent S, Asselin E.

Int J Oncol. 2004 May;24(5):1311-24.


Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.

Lu Y, Yu Q, Liu JH, Zhang J, Wang H, Koul D, McMurray JS, Fang X, Yung WK, Siminovitch KA, Mills GB.

J Biol Chem. 2003 Oct 10;278(41):40057-66. Epub 2003 Jul 17.


Pharmacogenomic profiling of the PI3K/PTEN-AKT-mTOR pathway in common human tumors.

Xu G, Zhang W, Bertram P, Zheng XF, McLeod H.

Int J Oncol. 2004 Apr;24(4):893-900.


PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway.

Kim S, Domon-Dell C, Wang Q, Chung DH, Di Cristofano A, Pandolfi PP, Freund JN, Evers BM.

Gastroenterology. 2002 Oct;123(4):1163-78.


Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B.

Lizcano JM, Alrubaie S, Kieloch A, Deak M, Leevers SJ, Alessi DR.

Biochem J. 2003 Sep 1;374(Pt 2):297-306.


Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells.

Van de Sande T, De Schrijver E, Heyns W, Verhoeven G, Swinnen JV.

Cancer Res. 2002 Feb 1;62(3):642-6.


Loss of PTEN expression leading to high Akt activation in human multiple myelomas.

Hyun T, Yam A, Pece S, Xie X, Zhang J, Miki T, Gutkind JS, Li W.

Blood. 2000 Nov 15;96(10):3560-8.


Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster.

Miron M, Lasko P, Sonenberg N.

Mol Cell Biol. 2003 Dec;23(24):9117-26.

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