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Items: 1 to 20 of 319

1.

TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68.

Wei JH, Chou YF, Ou YH, Yeh YH, Tyan SW, Sun TP, Shen CY, Shieh SY.

J Biol Chem. 2005 Mar 4;280(9):7748-57. Epub 2004 Dec 23.

2.

The cell cycle checkpoint kinase CHK2 mediates DNA damage-induced stabilization of TTK/hMps1.

Yeh YH, Huang YF, Lin TY, Shieh SY.

Oncogene. 2009 Mar 12;28(10):1366-78. doi: 10.1038/onc.2008.477. Epub 2009 Jan 19.

PMID:
19151762
3.

Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.

Bahassi el M, Myer DL, McKenney RJ, Hennigan RF, Stambrook PJ.

Mutat Res. 2006 Apr 11;596(1-2):166-76. Epub 2006 Feb 14.

PMID:
16481012
4.

The Plk1 Polo box domain mediates a cell cycle and DNA damage regulated interaction with Chk2.

Tsvetkov LM, Tsekova RT, Xu X, Stern DF.

Cell Cycle. 2005 Apr;4(4):609-17. Epub 2005 Apr 9.

PMID:
15876876
5.

The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe.

Castedo M, Perfettini JL, Roumier T, Yakushijin K, Horne D, Medema R, Kroemer G.

Oncogene. 2004 May 27;23(25):4353-61.

PMID:
15048074
6.

Genistein-induced neuronal apoptosis and G2/M cell cycle arrest is associated with MDC1 up-regulation and PLK1 down-regulation.

Ismail IA, Kang KS, Lee HA, Kim JW, Sohn YK.

Eur J Pharmacol. 2007 Dec 1;575(1-3):12-20. Epub 2007 Jul 28.

PMID:
17706963
7.

Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation.

Wei F, Xie Y, Tao L, Tang D.

Cell Signal. 2010 Nov;22(11):1783-9. doi: 10.1016/j.cellsig.2010.07.007. Epub 2010 Jul 15.

PMID:
20637859
8.

Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53.

Tominaga K, Morisaki H, Kaneko Y, Fujimoto A, Tanaka T, Ohtsubo M, Hirai M, Okayama H, Ikeda K, Nakanishi M.

J Biol Chem. 1999 Oct 29;274(44):31463-7.

9.

Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.

Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W.

J Biol Chem. 2001 Nov 16;276(46):43305-12. Epub 2001 Sep 10.

11.

Genistein arrests hepatoma cells at G2/M phase: involvement of ATM activation and upregulation of p21waf1/cip1 and Wee1.

Chang KL, Kung ML, Chow NH, Su SJ.

Biochem Pharmacol. 2004 Feb 15;67(4):717-26.

PMID:
14757171
12.

Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation.

Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ.

Oncogene. 2004 Apr 8;23(15):2658-63.

PMID:
14968113
13.
14.

Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer.

Matsuoka S, Nakagawa T, Masuda A, Haruki N, Elledge SJ, Takahashi T.

Cancer Res. 2001 Jul 15;61(14):5362-5.

15.

Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin.

Zimmermann M, Arachchige-Don AS, Donaldson MS, Dallapiazza RF, Cowan CE, Horne MC.

J Biol Chem. 2012 Jun 29;287(27):22838-53. doi: 10.1074/jbc.M112.376855. Epub 2012 May 15.

17.
18.

DNA damage checkpoint kinase Chk2 triggers replicative senescence.

Gire V, Roux P, Wynford-Thomas D, Brondello JM, Dulic V.

EMBO J. 2004 Jul 7;23(13):2554-63. Epub 2004 Jun 10.

19.
20.

The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway.

Tosti E, Waldbaum L, Warshaw G, Gross EA, Ruggieri R.

J Biol Chem. 2004 Nov 12;279(46):47652-60. Epub 2004 Sep 1.

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