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Items: 1 to 20 of 156

1.

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

Jia J, Tong C, Wang B, Luo L, Jiang J.

Nature. 2004 Dec 23;432(7020):1045-50.

PMID:
15616566
2.

Sequential phosphorylation of smoothened transduces graded hedgehog signaling.

Su Y, Ospina JK, Zhang J, Michelson AP, Schoen AM, Zhu AJ.

Sci Signal. 2011 Jul 5;4(180):ra43. doi: 10.1126/scisignal.2001747.

3.

Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila.

Jiang K, Liu Y, Fan J, Epperly G, Gao T, Jiang J, Jia J.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4842-50. doi: 10.1073/pnas.1417147111. Epub 2014 Oct 27.

4.

Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction.

Apionishev S, Katanayeva NM, Marks SA, Kalderon D, Tomlinson A.

Nat Cell Biol. 2005 Jan;7(1):86-92. Epub 2004 Dec 12.

PMID:
15592457
5.

Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation.

Li S, Ma G, Wang B, Jiang J.

Sci Signal. 2014 Jul 1;7(332):ra62. doi: 10.1126/scisignal.2005414.

6.

G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.

Ogden SK, Fei DL, Schilling NS, Ahmed YF, Hwa J, Robbins DJ.

Nature. 2008 Dec 18;456(7224):967-70. doi: 10.1038/nature07459.

7.
8.
9.

Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus.

Jia H, Liu Y, Xia R, Tong C, Yue T, Jiang J, Jia J.

J Biol Chem. 2010 Nov 26;285(48):37218-26. doi: 10.1074/jbc.M110.174565. Epub 2010 Sep 27.

10.

Extensive phosphorylation of Smoothened in Hedgehog pathway activation.

Zhang C, Williams EH, Guo Y, Lum L, Beachy PA.

Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):17900-7. Epub 2004 Dec 14.

11.

Analysis of Smoothened Phosphorylation and Activation in Cultured Cells and Wing Discs of Drosophila.

Jiang K, Jia J.

Methods Mol Biol. 2015;1322:45-60. doi: 10.1007/978-1-4939-2772-2_5.

PMID:
26179038
12.

Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling.

Ruel L, Gallet A, Raisin S, Truchi A, Staccini-Lavenant L, Cervantes A, Thérond PP.

Development. 2007 Oct;134(20):3677-89. Epub 2007 Sep 19.

13.

Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila.

Li S, Chen Y, Shi Q, Yue T, Wang B, Jiang J.

PLoS Biol. 2012 Jan;10(1):e1001239. doi: 10.1371/journal.pbio.1001239. Epub 2012 Jan 10.

14.

Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex.

Ranieri N, Thérond PP, Ruel L.

Nat Commun. 2014 Oct 7;5:5034. doi: 10.1038/ncomms6034.

PMID:
25289679
15.

Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila.

Nakano Y, Nystedt S, Shivdasani AA, Strutt H, Thomas C, Ingham PW.

Mech Dev. 2004 Jun;121(6):507-18.

16.

Regulation of smoothened by Drosophila G-protein-coupled receptor kinases.

Cheng S, Maier D, Neubueser D, Hipfner DR.

Dev Biol. 2010 Jan 1;337(1):99-109. doi: 10.1016/j.ydbio.2009.10.014. Epub 2009 Oct 20.

17.

A broadly conserved g-protein-coupled receptor kinase phosphorylation mechanism controls Drosophila smoothened activity.

Maier D, Cheng S, Faubert D, Hipfner DR.

PLoS Genet. 2014 Jul 10;10(7):e1004399. doi: 10.1371/journal.pgen.1004399. eCollection 2014 Jul.

18.
19.

Transducing the Hedgehog signal across the plasma membrane.

Zhao Y, Tong C, Jiang J.

Fly (Austin). 2007 Nov-Dec;1(6):333-6. Epub 2007 Nov 15. Review.

PMID:
18820483
20.

Hedgehog regulates smoothened activity by inducing a conformational switch.

Zhao Y, Tong C, Jiang J.

Nature. 2007 Nov 8;450(7167):252-8. Epub 2007 Oct 24.

PMID:
17960137

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