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Items: 1 to 20 of 166

1.

Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway.

Fukuhara S, Sakurai A, Sano H, Yamagishi A, Somekawa S, Takakura N, Saito Y, Kangawa K, Mochizuki N.

Mol Cell Biol. 2005 Jan;25(1):136-46.

2.

Vascular endothelial-cadherin stabilizes at cell-cell junctions by anchoring to circumferential actin bundles through alpha- and beta-catenins in cyclic AMP-Epac-Rap1 signal-activated endothelial cells.

Noda K, Zhang J, Fukuhara S, Kunimoto S, Yoshimura M, Mochizuki N.

Mol Biol Cell. 2010 Feb 15;21(4):584-96. doi: 10.1091/mbc.E09-07-0580. Epub 2009 Dec 23.

3.

Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor.

Rangarajan S, Enserink JM, Kuiperij HB, de Rooij J, Price LS, Schwede F, Bos JL.

J Cell Biol. 2003 Feb 17;160(4):487-93. Epub 2003 Feb 10.

4.

Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery.

Adamson RH, Ly JC, Sarai RK, Lenz JF, Altangerel A, Drenckhahn D, Curry FE.

Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1188-96. doi: 10.1152/ajpheart.00937.2007. Epub 2008 Jan 4.

5.

Prostacyclin post-treatment improves LPS-induced acute lung injury and endothelial barrier recovery via Rap1.

Birukova AA, Meng F, Tian Y, Meliton A, Sarich N, Quilliam LA, Birukov KG.

Biochim Biophys Acta. 2015 May;1852(5):778-91. doi: 10.1016/j.bbadis.2014.12.016. Epub 2014 Dec 26.

6.

Epac1 regulates integrity of endothelial cell junctions through VE-cadherin.

Kooistra MR, Corada M, Dejana E, Bos JL.

FEBS Lett. 2005 Sep 12;579(22):4966-72.

7.

MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion.

Sakurai A, Fukuhara S, Yamagishi A, Sako K, Kamioka Y, Masuda M, Nakaoka Y, Mochizuki N.

Mol Biol Cell. 2006 Feb;17(2):966-76. Epub 2005 Dec 7.

8.

Rac GTPase is a hub for protein kinase A and Epac signaling in endothelial barrier protection by cAMP.

Birukova AA, Burdette D, Moldobaeva N, Xing J, Fu P, Birukov KG.

Microvasc Res. 2010 Mar;79(2):128-38. doi: 10.1016/j.mvr.2009.11.007. Epub 2009 Dec 3.

9.

[Signaling mechanism involved in regulation of endothelial cell-cell junctions].

Fukuhara S, Mochizuki N.

Yakugaku Zasshi. 2010 Nov;130(11):1413-20. Review. Japanese.

10.

Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation.

Birukova AA, Zagranichnaya T, Fu P, Alekseeva E, Chen W, Jacobson JR, Birukov KG.

Exp Cell Res. 2007 Jul 1;313(11):2504-20. Epub 2007 Apr 6.

12.

Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability.

Rampersad SN, Ovens JD, Huston E, Umana MB, Wilson LS, Netherton SJ, Lynch MJ, Baillie GS, Houslay MD, Maurice DH.

J Biol Chem. 2010 Oct 29;285(44):33614-22. doi: 10.1074/jbc.M110.140004. Epub 2010 Aug 23.

13.

Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways.

Li J, O'Connor KL, Cheng X, Mei FC, Uchida T, Townsend CM Jr, Evers BM.

Mol Endocrinol. 2007 Jan;21(1):159-71. Epub 2006 Oct 26.

PMID:
17068197
14.

Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU.

Murphy MM, Zayed MA, Evans A, Parker CE, Ataga KI, Telen MJ, Parise LV.

Blood. 2005 Apr 15;105(8):3322-9. Epub 2004 Dec 21.

15.

Proline-rich tyrosine kinase 2 (Pyk2) mediates vascular endothelial-cadherin-based cell-cell adhesion by regulating beta-catenin tyrosine phosphorylation.

van Buul JD, Anthony EC, Fernandez-Borja M, Burridge K, Hordijk PL.

J Biol Chem. 2005 Jun 3;280(22):21129-36. Epub 2005 Mar 18.

16.

Enhanced functional gap junction neoformation by protein kinase A-dependent and Epac-dependent signals downstream of cAMP in cardiac myocytes.

Somekawa S, Fukuhara S, Nakaoka Y, Fujita H, Saito Y, Mochizuki N.

Circ Res. 2005 Sep 30;97(7):655-62. Epub 2005 Aug 25.

17.

Functions for the cAMP/Epac/Rap1 Signaling Pathway in Low-Dose Endothelial Monocyte-Activating Polypeptide-II-Induced Opening of Blood-Tumor Barrier.

Li Z, Liu XB, Liu YH, Xue YX, Wang P, Liu LB, Yao YL, Ma J.

J Mol Neurosci. 2015 Sep;57(1):1-10. doi: 10.1007/s12031-015-0594-6. Epub 2015 Jun 5.

PMID:
26044663
18.

Molecular mechanisms mediating protective effect of cAMP on lipopolysaccharide (LPS)-induced human lung microvascular endothelial cells (HLMVEC) hyperpermeability.

Bogatcheva NV, Zemskova MA, Kovalenkov Y, Poirier C, Verin AD.

J Cell Physiol. 2009 Dec;221(3):750-9. doi: 10.1002/jcp.21913.

19.

Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation.

Wang Z, Dillon TJ, Pokala V, Mishra S, Labudda K, Hunter B, Stork PJ.

Mol Cell Biol. 2006 Mar;26(6):2130-45.

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