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Items: 1 to 20 of 141


Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle.

Cuthbertson D, Smith K, Babraj J, Leese G, Waddell T, Atherton P, Wackerhage H, Taylor PM, Rennie MJ.

FASEB J. 2005 Mar;19(3):422-4. Epub 2004 Dec 13.


Leucine-enriched essential amino acid supplementation during moderate steady state exercise enhances postexercise muscle protein synthesis.

Pasiakos SM, McClung HL, McClung JP, Margolis LM, Andersen NE, Cloutier GJ, Pikosky MA, Rood JC, Fielding RA, Young AJ.

Am J Clin Nutr. 2011 Sep;94(3):809-18. doi: 10.3945/ajcn.111.017061. Epub 2011 Jul 20.


Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging.

Drummond MJ, Dreyer HC, Pennings B, Fry CS, Dhanani S, Dillon EL, Sheffield-Moore M, Volpi E, Rasmussen BB.

J Appl Physiol (1985). 2008 May;104(5):1452-61. doi: 10.1152/japplphysiol.00021.2008. Epub 2008 Mar 6.


Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults.

Drummond MJ, Dickinson JM, Fry CS, Walker DK, Gundermann DM, Reidy PT, Timmerman KL, Markofski MM, Paddon-Jones D, Rasmussen BB, Volpi E.

Am J Physiol Endocrinol Metab. 2012 May 15;302(9):E1113-22. doi: 10.1152/ajpendo.00603.2011. Epub 2012 Feb 14.


Branched-chain amino acids as fuels and anabolic signals in human muscle.

Rennie MJ, Bohé J, Smith K, Wackerhage H, Greenhaff P.

J Nutr. 2006 Jan;136(1 Suppl):264S-8S. Review.


Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling.

Atherton PJ, Etheridge T, Watt PW, Wilkinson D, Selby A, Rankin D, Smith K, Rennie MJ.

Am J Clin Nutr. 2010 Nov;92(5):1080-8. doi: 10.3945/ajcn.2010.29819. Epub 2010 Sep 15.


The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply.

Mitchell WK, Phillips BE, Williams JP, Rankin D, Lund JN, Wilkinson DJ, Smith K, Atherton PJ.

Am J Physiol Endocrinol Metab. 2015 Sep 1;309(5):E450-7. doi: 10.1152/ajpendo.00112.2015. Epub 2015 Jul 7.


Whey and casein labeled with L-[1-13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion.

Reitelseder S, Agergaard J, Doessing S, Helmark IC, Lund P, Kristensen NB, Frystyk J, Flyvbjerg A, Schjerling P, van Hall G, Kjaer M, Holm L.

Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E231-42. doi: 10.1152/ajpendo.00513.2010. Epub 2010 Nov 2.


Anabolic signaling and protein synthesis in human skeletal muscle after dynamic shortening or lengthening exercise.

Cuthbertson DJ, Babraj J, Smith K, Wilkes E, Fedele MJ, Esser K, Rennie M.

Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E731-8. Epub 2005 Nov 1.


Glucocorticoids modulate amino acid-induced translation initiation in human skeletal muscle.

Liu Z, Li G, Kimball SR, Jahn LA, Barrett EJ.

Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E275-81. Epub 2004 Mar 23.


Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise.

West DW, Burd NA, Coffey VG, Baker SK, Burke LM, Hawley JA, Moore DR, Stellingwerff T, Phillips SM.

Am J Clin Nutr. 2011 Sep;94(3):795-803. doi: 10.3945/ajcn.111.013722. Epub 2011 Jul 27.


Activation of mTORC1 by leucine is potentiated by branched-chain amino acids and even more so by essential amino acids following resistance exercise.

Moberg M, Apró W, Ekblom B, van Hall G, Holmberg HC, Blomstrand E.

Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C874-84. doi: 10.1152/ajpcell.00374.2015. Epub 2016 Apr 6.


Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids.

Dickinson JM, Fry CS, Drummond MJ, Gundermann DM, Walker DK, Glynn EL, Timmerman KL, Dhanani S, Volpi E, Rasmussen BB.

J Nutr. 2011 May;141(5):856-62. doi: 10.3945/jn.111.139485. Epub 2011 Mar 23.


Essential amino acids regulate both initiation and elongation of mRNA translation independent of insulin in MAC-T cells and bovine mammary tissue slices.

Appuhamy JA, Bell AL, Nayananjalie WA, Escobar J, Hanigan MD.

J Nutr. 2011 Jun;141(6):1209-15. doi: 10.3945/jn.110.136143. Epub 2011 Apr 27.


Isoleucine and leucine independently regulate mTOR signaling and protein synthesis in MAC-T cells and bovine mammary tissue slices.

Appuhamy JA, Knoebel NA, Nayananjalie WA, Escobar J, Hanigan MD.

J Nutr. 2012 Mar;142(3):484-91. doi: 10.3945/jn.111.152595. Epub 2012 Feb 1.


Supplemental dietary leucine and the skeletal muscle anabolic response to essential amino acids.

Pasiakos SM, McClung JP.

Nutr Rev. 2011 Sep;69(9):550-7. doi: 10.1111/j.1753-4887.2011.00420.x. Review.


Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle.

Dreyer HC, Drummond MJ, Pennings B, Fujita S, Glynn EL, Chinkes DL, Dhanani S, Volpi E, Rasmussen BB.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E392-400. Epub 2007 Dec 4.


Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men.

Moore DR, Robinson MJ, Fry JL, Tang JE, Glover EI, Wilkinson SB, Prior T, Tarnopolsky MA, Phillips SM.

Am J Clin Nutr. 2009 Jan;89(1):161-8. doi: 10.3945/ajcn.2008.26401. Epub 2008 Dec 3.


An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle.

Drummond MJ, Glynn EL, Fry CS, Timmerman KL, Volpi E, Rasmussen BB.

Am J Physiol Endocrinol Metab. 2010 May;298(5):E1011-8. doi: 10.1152/ajpendo.00690.2009. Epub 2010 Feb 9.


Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans.

Guillet C, Prod'homme M, Balage M, Gachon P, Giraudet C, Morin L, Grizard J, Boirie Y.

FASEB J. 2004 Oct;18(13):1586-7. Epub 2004 Aug 19.


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