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Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11.

Landrette SF, Kuo YH, Hensen K, Barjesteh van Waalwijk van Doorn-Khosrovani S, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH.

Blood. 2005 Apr 1;105(7):2900-7. Epub 2004 Dec 7.


Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia.

Kuo YH, Landrette SF, Heilman SA, Perrat PN, Garrett L, Liu PP, Le Beau MM, Kogan SC, Castilla LH.

Cancer Cell. 2006 Jan;9(1):57-68.


Cbfbeta reduces Cbfbeta-SMMHC-associated acute myeloid leukemia in mice.

Heilman SA, Kuo YH, Goudswaard CS, Valk PJ, Castilla LH.

Cancer Res. 2006 Dec 1;66(23):11214-8.


Mechanism of leukemogenesis by the inv(16) chimeric gene CBFB/PEBP2B-MHY11.

Shigesada K, van de Sluis B, Liu PP.

Oncogene. 2004 May 24;23(24):4297-307. Review.


Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11.

Kundu M, Chen A, Anderson S, Kirby M, Xu L, Castilla LH, Bodine D, Liu PP.

Blood. 2002 Oct 1;100(7):2449-56.


CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16).

Helbling D, Mueller BU, Timchenko NA, Schardt J, Eyer M, Betts DR, Jotterand M, Meyer-Monard S, Fey MF, Pabst T.

Blood. 2005 Aug 15;106(4):1369-75. Epub 2005 Apr 26.


The chimeric protein, PEBP2 beta/CBF beta-SMMHC, disorganizes cytoplasmic stress fibers and inhibits transcriptional activation.

Tanaka Y, Fujii M, Hayashi K, Chiba N, Akaishi T, Shineha R, Nishihira T, Satomi S, Ito Y, Watanabe T, Satake M.

Oncogene. 1998 Aug 13;17(6):699-708.


CBFbeta-SMMHC slows proliferation of primary murine and human myeloid progenitors.

D'Costa J, Chaudhuri S, Civin CI, Friedman AD.

Leukemia. 2005 Jun;19(6):921-9.


Function of the inv(16) fusion gene CBFB-MYH11.

Kundu M, Liu PP.

Curr Opin Hematol. 2001 Jul;8(4):201-5. Review.


c-Myc overcomes cell cycle inhibition by CBFbeta-SMMHC, a myeloid leukemia oncoprotein.

Bernardin F, Yang Y, Civin CI, Friedman AD.

Cancer Biol Ther. 2002 Sep-Oct;1(5):492-6.


Core binding factor beta-smooth muscle myosin heavy chain chimeric protein involved in acute myeloid leukemia forms unusual nuclear rod-like structures in transformed NIH 3T3 cells.

Wijmenga C, Gregory PE, Hajra A, Schröck E, Ried T, Eils R, Liu PP, Collins FS.

Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1630-5. Erratum in: Proc Natl Acad Sci U S A 1996 Dec 24;93(26):15522.


Heterogeneity in CBF beta/MYH11 fusion messages encoded by the inv(16)(p13q22) and the t(16;16)(p13;q22) in acute myelogenous leukemia.

Shurtleff SA, Meyers S, Hiebert SW, Raimondi SC, Head DR, Willman CL, Wolman S, Slovak ML, Carroll AJ, Behm F, et al.

Blood. 1995 Jun 15;85(12):3695-703.


Sumoylation and acetylation play opposite roles in the transactivation of PLAG1 and PLAGL2.

Zheng G, Yang YC.

J Biol Chem. 2005 Dec 9;280(49):40773-81. Epub 2005 Oct 5.


Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia.

Castilla LH, Perrat P, Martinez NJ, Landrette SF, Keys R, Oikemus S, Flanegan J, Heilman S, Garrett L, Dutra A, Anderson S, Pihan GA, Wolff L, Liu PP.

Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4924-9. Epub 2004 Mar 24.


Acceleration of G(1) cooperates with core binding factor beta-smooth muscle myosin heavy chain to induce acute leukemia in mice.

Yang Y, Wang W, Cleaves R, Zahurak M, Cheng L, Civin CI, Friedman AD.

Cancer Res. 2002 Apr 15;62(8):2232-5.


Common gene expression signatures in t(8;21)- and inv(16)-acute myeloid leukaemia.

Ichikawa H, Tanabe K, Mizushima H, Hayashi Y, Mizutani S, Ishii E, Hongo T, Kikuchi A, Satake M.

Br J Haematol. 2006 Nov;135(3):336-47. Epub 2006 Sep 21.


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