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Scaffolding by ERK3 regulates MK5 in development.

Schumacher S, Laass K, Kant S, Shi Y, Visel A, Gruber AD, Kotlyarov A, Gaestel M.

EMBO J. 2004 Dec 8;23(24):4770-9. Epub 2004 Nov 11.


Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5.

Kant S, Schumacher S, Singh MK, Kispert A, Kotlyarov A, Gaestel M.

J Biol Chem. 2006 Nov 17;281(46):35511-9. Epub 2006 Sep 13.


Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5.

Déléris P, Rousseau J, Coulombe P, Rodier G, Tanguay PL, Meloche S.

J Cell Physiol. 2008 Dec;217(3):778-88. doi: 10.1002/jcp.21560.


Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway.

Seternes OM, Mikalsen T, Johansen B, Michaelsen E, Armstrong CG, Morrice NA, Turgeon B, Meloche S, Moens U, Keyse SM.

EMBO J. 2004 Dec 8;23(24):4780-91. Epub 2004 Dec 2. Erratum in: EMBO J. 2005 Feb 23;24(4):873.


Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4.

Aberg E, Perander M, Johansen B, Julien C, Meloche S, Keyse SM, Seternes OM.

J Biol Chem. 2006 Nov 17;281(46):35499-510. Epub 2006 Sep 13.


The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5.

Perander M, Aberg E, Johansen B, Dreyer B, Guldvik IJ, Outzen H, Keyse SM, Seternes OM.

Biochem J. 2008 May 1;411(3):613-22. doi: 10.1042/BJ20071369.


The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology.

Brand F, Schumacher S, Kant S, Menon MB, Simon R, Turgeon B, Britsch S, Meloche S, Gaestel M, Kotlyarov A.

Mol Cell Biol. 2012 Jul;32(13):2467-78. doi: 10.1128/MCB.06633-11. Epub 2012 Apr 16.


Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif.

Aberg E, Torgersen KM, Johansen B, Keyse SM, Perander M, Seternes OM.

J Biol Chem. 2009 Jul 17;284(29):19392-401. doi: 10.1074/jbc.M109.023283. Epub 2009 May 27.


Does MK5 reconcile classical and atypical MAP kinases?

Perander M, Keyse SM, Seternes OM.

Front Biosci. 2008 May 1;13:4617-24.


Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination.

Shi Y, Kotlyarov A, Laabeta K, Gruber AD, Butt E, Marcus K, Meyer HE, Friedrich A, Volk HD, Gaestel M.

Mol Cell Biol. 2003 Nov;23(21):7732-41.


Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.

Déléris P, Trost M, Topisirovic I, Tanguay PL, Borden KL, Thibault P, Meloche S.

J Biol Chem. 2011 Feb 25;286(8):6470-8. doi: 10.1074/jbc.M110.181529. Epub 2010 Dec 22.


Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo.

Robinson MJ, Xu Be BE, Stippec S, Cobb MH.

J Biol Chem. 2002 Feb 15;277(7):5094-100. Epub 2001 Dec 6.


A novel role for atypical MAPK kinase ERK3 in regulating breast cancer cell morphology and migration.

Al-Mahdi R, Babteen N, Thillai K, Holt M, Johansen B, Wetting HL, Seternes OM, Wells CM.

Cell Adh Migr. 2015;9(6):483-94. doi: 10.1080/19336918.2015.1112485.


Characterization of the expression and regulation of MK5 in the murine ventricular myocardium.

Dingar D, Benoit MJ, Mamarbachi AM, Villeneuve LR, Gillis MA, Grandy S, Gaestel M, Fiset C, Allen BG.

Cell Signal. 2010 Jul;22(7):1063-75. doi: 10.1016/j.cellsig.2010.02.009. Epub 2010 Mar 7.


Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3.

Sun M, Wei Y, Yao L, Xie J, Chen X, Wang H, Jiang J, Gu J.

Biochem Biophys Res Commun. 2006 Feb 3;340(1):209-14. Epub 2005 Dec 9.


PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5.

Kostenko S, Johannessen M, Moens U.

Cell Signal. 2009 May;21(5):712-8. doi: 10.1016/j.cellsig.2009.01.009. Epub 2009 Jan 8.


New insights into the activation, interaction partners and possible functions of MK5/PRAK.

Perander M, Keyse SM, Seternes OM.

Front Biosci (Landmark Ed). 2016 Jan 1;21:374-84. Review.


The transcriptional regulation and cell-specific expression of the MAPK-activated protein kinase MK5.

Gerits N, Shiryaev A, Kostenko S, Klenow H, Shiryaeva O, Johannessen M, Moens U.

Cell Mol Biol Lett. 2009;14(4):548-74. doi: 10.2478/s11658-009-0020-6. Epub 2009 May 30.


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