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Items: 1 to 20 of 185

1.

The porphobilinogen synthase catalyzed reaction mechanism.

Jaffe EK.

Bioorg Chem. 2004 Oct;32(5):316-25. Review.

PMID:
15381398
2.

Mechanistic implications of mutations to the active site lysine of porphobilinogen synthase.

Mitchell LW, Volin M, Martins J, Jaffe EK.

J Biol Chem. 2001 Jan 12;276(2):1538-44.

3.
4.

Mechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid, an inhibitor that shows dramatic species selectivity.

Kervinen J, Jaffe EK, Stauffer F, Neier R, Wlodawer A, Zdanov A.

Biochemistry. 2001 Jul 27;40(28):8227-36.

PMID:
11444968
5.

Structure of porphobilinogen synthase from Pseudomonas aeruginosa in complex with 5-fluorolevulinic acid suggests a double Schiff base mechanism.

Frère F, Schubert WD, Stauffer F, Frankenberg N, Neier R, Jahn D, Heinz DW.

J Mol Biol. 2002 Jul 5;320(2):237-47.

PMID:
12079382
7.

5-Chlorolevulinate modification of porphobilinogen synthase identifies a potential role for the catalytic zinc.

Jaffe EK, Abrams WR, Kaempfen HX, Harris KA Jr.

Biochemistry. 1992 Feb 25;31(7):2113-23.

PMID:
1346974
8.

Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid.

Jaffe EK, Kervinen J, Martins J, Stauffer F, Neier R, Wlodawer A, Zdanov A.

J Biol Chem. 2002 May 31;277(22):19792-9. Epub 2002 Mar 21.

9.

Computational insights into the mechanism of porphobilinogen synthase.

Erdtman E, Bushnell EA, Gauld JW, Eriksson LA.

J Phys Chem B. 2010 Dec 23;114(50):16860-70. doi: 10.1021/jp103590d. Epub 2010 Nov 23.

PMID:
21090799
10.
11.
12.

Porphobilinogen synthase from pea: expression from an artificial gene, kinetic characterization, and novel implications for subunit interactions.

Kervinen J, Dunbrack RL Jr, Litwin S, Martins J, Scarrow RC, Volin M, Yeung AT, Yoon E, Jaffe EK.

Biochemistry. 2000 Aug 1;39(30):9018-29.

PMID:
10913315
13.
14.

Tracking the evolution of porphobilinogen synthase metal dependence in vitro.

Frère F, Reents H, Schubert WD, Heinz DW, Jahn D.

J Mol Biol. 2005 Feb 4;345(5):1059-70. Epub 2004 Dec 21.

PMID:
15644204
15.

Crystallization and preliminary X-ray diffraction studies of E. coli porphobilinogen synthase and its heavy-atom derivatives.

Shimoni-Livny L, Carrell HL, Wagner T, Kaufman Katz A, Afshar C, Mitchell LW, Volin M, Jaffe EK, Glusker JP.

Acta Crystallogr D Biol Crystallogr. 1998 May 1;54(Pt 3):438-40.

PMID:
9761921
16.

Characterization of the role of the stimulatory magnesium of Escherichia coli porphobilinogen synthase.

Jaffe EK, Ali S, Mitchell LW, Taylor KM, Volin M, Markham GD.

Biochemistry. 1995 Jan 10;34(1):244-51.

PMID:
7819203
17.

High resolution crystal structure of a Mg2+-dependent porphobilinogen synthase.

Frankenberg N, Erskine PT, Cooper JB, Shoolingin-Jordan PM, Jahn D, Heinz DW.

J Mol Biol. 1999 Jun 11;289(3):591-602.

PMID:
10356331
18.

5-Aminolaevulinic acid dehydratase: metals, mutants and mechanism.

Shoolingin-Jordan PM, Spencer P, Sarwar M, Erskine PE, Cheung KM, Cooper JB, Norton EB.

Biochem Soc Trans. 2002 Aug;30(4):584-90. Review.

PMID:
12196142
19.

Porphobilinogen synthase from Escherichia coli is a Zn(II) metalloenzyme stimulated by Mg(II).

Mitchell LW, Jaffe EK.

Arch Biochem Biophys. 1993 Jan;300(1):169-77.

PMID:
8424649
20.

Inhibition studies of porphobilinogen synthase from Escherichia coli differentiating between the two recognition sites.

Stauffer F, Zizzari E, Engeloch-Jarret C, Faurite JP, Bobálová J, Neier R.

Chembiochem. 2001 May 4;2(5):343-54.

PMID:
11828463

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