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Identification of a human heme exporter that is essential for erythropoiesis.

Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, Berg CL, Sassa S, Wood BL, Abkowitz JL.

Cell. 2004 Sep 17;118(6):757-66.


A heme export protein is required for red blood cell differentiation and iron homeostasis.

Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Vaughn MB, Kaplan J, Palis J, Abkowitz JL.

Science. 2008 Feb 8;319(5864):825-8. doi: 10.1126/science.1151133.


Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin.

Yang Z, Philips JD, Doty RT, Giraudi P, Ostrow JD, Tiribelli C, Smith A, Abkowitz JL.

J Biol Chem. 2010 Sep 10;285(37):28874-82. doi: 10.1074/jbc.M110.119131. Epub 2010 Jul 7.


TLR Stimulation Dynamically Regulates Heme and Iron Export Gene Expression in Macrophages.

Philip M, Chiu EY, Hajjar AM, Abkowitz JL.

J Immunol Res. 2016;2016:4039038. doi: 10.1155/2016/4039038. Epub 2016 Feb 24.


FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function.

Byon JC, Chen J, Doty RT, Abkowitz JL.

Blood. 2013 Oct 17;122(16):2903-10. doi: 10.1182/blood-2012-10-465104. Epub 2013 Sep 10.


Heme exporter FLVCR is required for T cell development and peripheral survival.

Philip M, Funkhouser SA, Chiu EY, Phelps SR, Delrow JJ, Cox J, Fink PJ, Abkowitz JL.

J Immunol. 2015 Feb 15;194(4):1677-85. doi: 10.4049/jimmunol.1402172. Epub 2015 Jan 12.


Heme and FLVCR-related transporter families SLC48 and SLC49.

Khan AA, Quigley JG.

Mol Aspects Med. 2013 Apr-Jun;34(2-3):669-82. doi: 10.1016/j.mam.2012.07.013. Review.


The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation.

Chiabrando D, Marro S, Mercurio S, Giorgi C, Petrillo S, Vinchi F, Fiorito V, Fagoonee S, Camporeale A, Turco E, Merlo GR, Silengo L, Altruda F, Pinton P, Tolosano E.

J Clin Invest. 2012 Dec;122(12):4569-79. doi: 10.1172/JCI62422. Epub 2012 Nov 26.


Coordinate expression of heme and globin is essential for effective erythropoiesis.

Doty RT, Phelps SR, Shadle C, Sanchez-Bonilla M, Keel SB, Abkowitz JL.

J Clin Invest. 2015 Dec;125(12):4681-91. doi: 10.1172/JCI83054. Epub 2015 Nov 9.


The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation.

Mercurio S, Petrillo S, Chiabrando D, Bassi ZI, Gays D, Camporeale A, Vacaru A, Miniscalco B, Valperga G, Silengo L, Altruda F, Baron MH, Santoro MM, Tolosano E.

Haematologica. 2015 Jun;100(6):720-9. doi: 10.3324/haematol.2014.114488. Epub 2015 Mar 20.


Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells.

Alves LR, Costa ES, Sorgine MH, Nascimento-Silva MC, Teodosio C, Bárcena P, Castro-Faria-Neto HC, Bozza PT, Orfao A, Oliveira PL, Maya-Monteiro CM.

PLoS One. 2011;6(7):e21358. doi: 10.1371/journal.pone.0021358. Epub 2011 Jul 13.


Investigation of a putative role for FLVCR, a cytoplasmic heme exporter, in Diamond-Blackfan anemia.

Quigley JG, Gazda H, Yang Z, Ball S, Sieff CA, Abkowitz JL.

Blood Cells Mol Dis. 2005 Sep-Oct;35(2):189-92.


Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450.

Vinchi F, Ingoglia G, Chiabrando D, Mercurio S, Turco E, Silengo L, Altruda F, Tolosano E.

Gastroenterology. 2014 May;146(5):1325-38. doi: 10.1053/j.gastro.2014.01.053. Epub 2014 Jan 31.


Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia.

Quigley JG, Burns CC, Anderson MM, Lynch ED, Sabo KM, Overbaugh J, Abkowitz JL.

Blood. 2000 Feb 1;95(3):1093-9. Erratum in: Blood 2000 Jul 1;96(1):8.


An all-feline retroviral packaging system for transduction of human cells.

Doty RT, Sabo KM, Chen J, Miller AD, Abkowitz JL.

Hum Gene Ther. 2010 Aug;21(8):1019-27. doi: 10.1089/hum.2010.032.


Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis.

Gnana-Prakasam JP, Reddy SK, Veeranan-Karmegam R, Smith SB, Martin PM, Ganapathy V.

Invest Ophthalmol Vis Sci. 2011 Nov 29;52(12):9279-86. doi: 10.1167/iovs.11-8264.


Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis.

Rey MA, Duffy SP, Brown JK, Kennedy JA, Dick JE, Dror Y, Tailor CS.

Haematologica. 2008 Nov;93(11):1617-26. doi: 10.3324/haematol.13359. Epub 2008 Sep 24.


Crucial Role of FLVCR1a in the Maintenance of Intestinal Heme Homeostasis.

Fiorito V, Forni M, Silengo L, Altruda F, Tolosano E.

Antioxid Redox Signal. 2015 Dec 20;23(18):1410-23. doi: 10.1089/ars.2014.6216. Epub 2015 Jul 20.


The Fowler syndrome-associated protein FLVCR2 is an importer of heme.

Duffy SP, Shing J, Saraon P, Berger LC, Eiden MV, Wilde A, Tailor CS.

Mol Cell Biol. 2010 Nov;30(22):5318-24. doi: 10.1128/MCB.00690-10. Epub 2010 Sep 7.

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