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Items: 1 to 20 of 181

1.
2.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.

Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M.

Mol Cell Biol. 2004 Aug;24(16):7130-9.

3.

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M.

Mol Cell Biol. 2004 Dec;24(24):10941-53.

5.

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.

Zhang DD, Lo SC, Sun Z, Habib GM, Lieberman MW, Hannink M.

J Biol Chem. 2005 Aug 26;280(34):30091-9. Epub 2005 Jun 27.

7.
8.

The Keap1-Nrf2 system as an in vivo sensor for electrophiles.

Uruno A, Motohashi H.

Nitric Oxide. 2011 Aug 1;25(2):153-60. doi: 10.1016/j.niox.2011.02.007. Epub 2011 Mar 6.

PMID:
21385624
9.

Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.

Villeneuve NF, Lau A, Zhang DD.

Antioxid Redox Signal. 2010 Dec 1;13(11):1699-712. doi: 10.1089/ars.2010.3211. Epub 2010 Aug 14. Review.

10.

Prothymosin-alpha mediates nuclear import of the INrf2/Cul3 Rbx1 complex to degrade nuclear Nrf2.

Niture SK, Jaiswal AK.

J Biol Chem. 2009 May 15;284(20):13856-68. doi: 10.1074/jbc.M808084200. Epub 2009 Mar 11. Retraction in: J Biol Chem. 2017 Feb 3;292(5):2049.

12.

Keap1 degradation by autophagy for the maintenance of redox homeostasis.

Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, Yamamoto M.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13561-6. doi: 10.1073/pnas.1121572109. Epub 2012 Aug 7.

13.

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm.

Zipper LM, Mulcahy RT.

J Biol Chem. 2002 Sep 27;277(39):36544-52. Epub 2002 Jul 26.

15.

Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes.

Kang MI, Kobayashi A, Wakabayashi N, Kim SG, Yamamoto M.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2046-51. Epub 2004 Feb 5.

16.

Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation.

Hong F, Sekhar KR, Freeman ML, Liebler DC.

J Biol Chem. 2005 Sep 9;280(36):31768-75. Epub 2005 Jun 28.

17.

Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells.

Iso T, Suzuki T, Baird L, Yamamoto M.

Mol Cell Biol. 2016 Nov 28;36(24):3100-3112. Print 2016 Dec 15.

18.

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.

Rada P, Rojo AI, Chowdhry S, McMahon M, Hayes JD, Cuadrado A.

Mol Cell Biol. 2011 Mar;31(6):1121-33. doi: 10.1128/MCB.01204-10. Epub 2011 Jan 18.

19.

Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes.

Ichikawa T, Li J, Meyer CJ, Janicki JS, Hannink M, Cui T.

PLoS One. 2009 Dec 21;4(12):e8391. doi: 10.1371/journal.pone.0008391.

20.

Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation.

Kobayashi M, Yamamoto M.

Antioxid Redox Signal. 2005 Mar-Apr;7(3-4):385-94. Review.

PMID:
15706085

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