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Items: 1 to 20 of 61

1.

A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.

Huang DT, Miller DW, Mathew R, Cassell R, Holton JM, Roussel MF, Schulman BA.

Nat Struct Mol Biol. 2004 Oct;11(10):927-35. Epub 2004 Sep 7.

2.

Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1.

Souphron J, Waddell MB, Paydar A, Tokgöz-Gromley Z, Roussel MF, Schulman BA.

Biochemistry. 2008 Aug 26;47(34):8961-9. doi: 10.1021/bi800604c. Epub 2008 Jul 25.

3.

Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.

Huang DT, Hunt HW, Zhuang M, Ohi MD, Holton JM, Schulman BA.

Nature. 2007 Jan 25;445(7126):394-8. Epub 2007 Jan 14.

4.

Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.

Huang DT, Paydar A, Zhuang M, Waddell MB, Holton JM, Schulman BA.

Mol Cell. 2005 Feb 4;17(3):341-50.

5.

The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.

Walden H, Podgorski MS, Huang DT, Miller DW, Howard RJ, Minor DL Jr, Holton JM, Schulman BA.

Mol Cell. 2003 Dec;12(6):1427-37.

6.

Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2.

Huang DT, Zhuang M, Ayrault O, Schulman BA.

Nat Struct Mol Biol. 2008 Mar;15(3):280-7. doi: 10.1038/nsmb.1387. Epub 2008 Feb 10.

PMID:
18264111
7.

E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.

Huang DT, Ayrault O, Hunt HW, Taherbhoy AM, Duda DM, Scott DC, Borg LA, Neale G, Murray PJ, Roussel MF, Schulman BA.

Mol Cell. 2009 Feb 27;33(4):483-95. doi: 10.1016/j.molcel.2009.01.011.

8.

Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways.

Wang J, Taherbhoy AM, Hunt HW, Seyedin SN, Miller DW, Miller DJ, Huang DT, Schulman BA.

PLoS One. 2010 Dec 30;5(12):e15805. doi: 10.1371/journal.pone.0015805.

9.
10.

Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.

Walden H, Podgorski MS, Schulman BA.

Nature. 2003 Mar 20;422(6929):330-4.

PMID:
12646924
11.

In vitro systems for NEDD8 conjugation by Ubc12.

Chiba T.

Methods Enzymol. 2005;398:68-73.

PMID:
16275320
12.

Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes.

Whitby FG, Xia G, Pickart CM, Hill CP.

J Biol Chem. 1998 Dec 25;273(52):34983-91.

13.

Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8.

Scott DC, Sviderskiy VO, Monda JK, Lydeard JR, Cho SE, Harper JW, Schulman BA.

Cell. 2014 Jun 19;157(7):1671-84. doi: 10.1016/j.cell.2014.04.037.

14.

Protein-protein interactions regulate Ubl conjugation.

Knipscheer P, Sixma TK.

Curr Opin Struct Biol. 2007 Dec;17(6):665-73. Epub 2007 Oct 15.

PMID:
17933515
15.
16.

E2-binding surface on Uba3 β-grasp domain undergoes a conformational transition.

Elgin ES, Sökmen N, Peterson FC, Volkman BF, Dağ C, Haas AL.

Proteins. 2012 Oct;80(10):2482-7. doi: 10.1002/prot.24148. Epub 2012 Jul 31.

PMID:
22821745
17.

The mechanism of poly-NEDD8 chain formation in vitro.

Ohki Y, Funatsu N, Konishi N, Chiba T.

Biochem Biophys Res Commun. 2009 Apr 10;381(3):443-7. doi: 10.1016/j.bbrc.2009.02.090. Epub 2009 Feb 24.

PMID:
19245792
18.

A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo.

Wada H, Yeh ET, Kamitani T.

J Biol Chem. 2000 Jun 2;275(22):17008-15.

19.

Profiling the cross reactivity of ubiquitin with the Nedd8 activating enzyme by phage display.

Zhao B, Zhang K, Bhuripanyo K, Choi CH, Villhauer EB, Li H, Zheng N, Kiyokawa H, Schindelin H, Yin J.

PLoS One. 2013 Aug 1;8(8):e70312. doi: 10.1371/journal.pone.0070312. Print 2013.

20.

E1-E2 interactions in ubiquitin and Nedd8 ligation pathways.

Tokgöz Z, Siepmann TJ, Streich F Jr, Kumar B, Klein JM, Haas AL.

J Biol Chem. 2012 Jan 2;287(1):311-21. doi: 10.1074/jbc.M111.294975. Epub 2011 Nov 8.

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