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Items: 1 to 20 of 151


Binding affinity of lactose permease is not altered by the H+ electrochemical gradient.

Guan L, Kaback HR.

Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12148-52. Epub 2004 Aug 10.


Site-directed alkylation and the alternating access model for LacY.

Kaback HR, Dunten R, Frillingos S, Venkatesan P, Kwaw I, Zhang W, Ermolova N.

Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):491-4. Epub 2006 Dec 15.


Lactose permease and the alternating access mechanism.

Smirnova I, Kasho V, Kaback HR.

Biochemistry. 2011 Nov 15;50(45):9684-93. doi: 10.1021/bi2014294. Epub 2011 Oct 19.


Site-directed alkylation of LacY: effect of the proton electrochemical gradient.

Nie Y, Ermolova N, Kaback HR.

J Mol Biol. 2007 Nov 23;374(2):356-64. Epub 2007 Sep 11.


The Cys154-->Gly mutation in LacY causes constitutive opening of the hydrophilic periplasmic pathway.

Nie Y, Sabetfard FE, Kaback HR.

J Mol Biol. 2008 Jun 13;379(4):695-703. doi: 10.1016/j.jmb.2008.04.015. Epub 2008 Apr 11.


Sugar recognition by CscB and LacY.

Sugihara J, Smirnova I, Kasho V, Kaback HR.

Biochemistry. 2011 Dec 27;50(51):11009-14. doi: 10.1021/bi201592y. Epub 2011 Dec 1.


The alternating access transport mechanism in LacY.

Kaback HR, Smirnova I, Kasho V, Nie Y, Zhou Y.

J Membr Biol. 2011 Jan;239(1-2):85-93. doi: 10.1007/s00232-010-9327-5. Epub 2010 Dec 16. Review.


Outward-facing conformers of LacY stabilized by nanobodies.

Smirnova I, Kasho V, Jiang X, Pardon E, Steyaert J, Kaback HR.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18548-53. doi: 10.1073/pnas.1422265112. Epub 2014 Dec 15.


Conservation of residues involved in sugar/H(+) symport by the sucrose permease of Escherichia coli relative to lactose permease.

Vadyvaloo V, Smirnova IN, Kasho VN, Kaback HR.

J Mol Biol. 2006 May 12;358(4):1051-9. Epub 2006 Mar 9.


Sugar binding induces the same global conformational change in purified LacY as in the native bacterial membrane.

Nie Y, Kaback HR.

Proc Natl Acad Sci U S A. 2010 May 25;107(21):9903-8. doi: 10.1073/pnas.1004515107. Epub 2010 May 10.


Role of the irreplaceable residues in the LacY alternating access mechanism.

Zhou Y, Jiang X, Kaback HR.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12438-42. doi: 10.1073/pnas.1210684109. Epub 2012 Jul 16.


Lessons from lactose permease.

Guan L, Kaback HR.

Annu Rev Biophys Biomol Struct. 2006;35:67-91. Review.


Residues gating the periplasmic pathway of LacY.

Zhou Y, Nie Y, Kaback HR.

J Mol Biol. 2009 Nov 27;394(2):219-25. doi: 10.1016/j.jmb.2009.09.043. Epub 2009 Sep 23.


Role of protons in sugar binding to LacY.

Smirnova I, Kasho V, Sugihara J, Vázquez-Ibar JL, Kaback HR.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16835-40. doi: 10.1073/pnas.1214890109. Epub 2012 Oct 2.


Real-time conformational changes in LacY.

Smirnova I, Kasho V, Kaback HR.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8440-5. doi: 10.1073/pnas.1408374111. Epub 2014 May 28.


Site-directed mutagenesis of cysteine-148 in the lac permease of Escherichia coli: effect on transport, binding, and sulfhydryl inactivation.

Viitanen PV, Menick DR, Sarkar HK, Trumble WR, Kaback HR.

Biochemistry. 1985 Dec 17;24(26):7628-35.


Probing the periplasmic-open state of lactose permease in response to sugar binding and proton translocation.

Pendse PY, Brooks BR, Klauda JB.

J Mol Biol. 2010 Dec 3;404(3):506-21. doi: 10.1016/j.jmb.2010.09.045. Epub 2010 Sep 25.


Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition.

Chaptal V, Kwon S, Sawaya MR, Guan L, Kaback HR, Abramson J.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9361-6. doi: 10.1073/pnas.1105687108. Epub 2011 May 18.


Direct sugar binding to LacY measured by resonance energy transfer.

Smirnova IN, Kasho VN, Kaback HR.

Biochemistry. 2006 Dec 26;45(51):15279-87. Epub 2006 Nov 29.

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