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Items: 1 to 20 of 254

1.

IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness.

Funato Y, Terabayashi T, Suenaga N, Seiki M, Takenawa T, Miki H.

Cancer Res. 2004 Aug 1;64(15):5237-44.

2.

EPS8 and E3B1 transduce signals from Ras to Rac.

Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, Gutkind S, Bjarnegård M, Betsholtz C, Di Fiore PP.

Nature. 1999 Sep 16;401(6750):290-3.

PMID:
10499589
3.

Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells.

Goicoechea S, Arneman D, Disanza A, Garcia-Mata R, Scita G, Otey CA.

J Cell Sci. 2006 Aug 15;119(Pt 16):3316-24.

4.

The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway.

Offenhäuser N, Borgonovo A, Disanza A, Romano P, Ponzanelli I, Iannolo G, Di Fiore PP, Scita G.

Mol Biol Cell. 2004 Jan;15(1):91-8.

5.

Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex.

Disanza A, Mantoani S, Hertzog M, Gerboth S, Frittoli E, Steffen A, Berhoerster K, Kreienkamp HJ, Milanesi F, Di Fiore PP, Ciliberto A, Stradal TE, Scita G.

Nat Cell Biol. 2006 Dec;8(12):1337-47.

PMID:
17115031
6.

An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine.

Scita G, Tenca P, Areces LB, Tocchetti A, Frittoli E, Giardina G, Ponzanelli I, Sini P, Innocenti M, Di Fiore PP.

J Cell Biol. 2001 Sep 3;154(5):1031-44.

7.

SPIN90-IRSp53 complex participates in Rac-induced membrane ruffling.

Teodorof C, Bae JI, Kim SM, Oh HJ, Kang YS, Choi J, Chun JS, Song WK.

Exp Cell Res. 2009 Aug 15;315(14):2410-9. doi: 10.1016/j.yexcr.2009.05.010.

PMID:
19460367
8.

The interplay between Eps8 and IRSp53 contributes to Src-mediated transformation.

Liu PS, Jong TH, Maa MC, Leu TH.

Oncogene. 2010 Jul 8;29(27):3977-89. doi: 10.1038/onc.2010.144.

PMID:
20418908
9.

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling.

Miki H, Yamaguchi H, Suetsugu S, Takenawa T.

Nature. 2000 Dec 7;408(6813):732-5.

PMID:
11130076
10.

Eps8 in the midst of GTPases.

Di Fiore PP, Scita G.

Int J Biochem Cell Biol. 2002 Oct;34(10):1178-83. Review.

PMID:
12127568
11.

The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.

Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP.

Nature. 2000 Nov 16;408(6810):374-7.

PMID:
11099046
12.

Eps8 controls actin-based motility by capping the barbed ends of actin filaments.

Disanza A, Carlier MF, Stradal TE, Didry D, Frittoli E, Confalonieri S, Croce A, Wehland J, Di Fiore PP, Scita G.

Nat Cell Biol. 2004 Dec;6(12):1180-8.

PMID:
15558031
13.

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.

Innocenti M, Tenca P, Frittoli E, Faretta M, Tocchetti A, Di Fiore PP, Scita G.

J Cell Biol. 2002 Jan 7;156(1):125-36.

14.

Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac.

Suetsugu S, Kurisu S, Oikawa T, Yamazaki D, Oda A, Takenawa T.

J Cell Biol. 2006 May 22;173(4):571-85.

15.

DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1.

Sanui T, Inayoshi A, Noda M, Iwata E, Stein JV, Sasazuki T, Fukui Y.

Blood. 2003 Oct 15;102(8):2948-50.

16.

Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1.

Van Leeuwen FN, Olivo C, Grivell S, Giepmans BN, Collard JG, Moolenaar WH.

J Biol Chem. 2003 Jan 3;278(1):400-6.

17.

WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac.

Miki H, Takenawa T.

Biochem Biophys Res Commun. 2002 Apr 26;293(1):93-9.

PMID:
12054568
18.

Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells.

Kurisu S, Suetsugu S, Yamazaki D, Yamaguchi H, Takenawa T.

Oncogene. 2005 Feb 17;24(8):1309-19.

PMID:
15608687
19.

Dock180-ELMO cooperation in Rac activation.

Lu M, Ravichandran KS.

Methods Enzymol. 2006;406:388-402.

PMID:
16472672
20.

Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex.

Krugmann S, Jordens I, Gevaert K, Driessens M, Vandekerckhove J, Hall A.

Curr Biol. 2001 Oct 30;11(21):1645-55.

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