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Items: 1 to 20 of 430

1.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.

Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M.

Mol Cell Biol. 2004 Aug;24(16):7130-9.

3.

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M.

Mol Cell Biol. 2004 Dec;24(24):10941-53.

4.

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.

Zhang DD, Lo SC, Sun Z, Habib GM, Lieberman MW, Hannink M.

J Biol Chem. 2005 Aug 26;280(34):30091-9. Epub 2005 Jun 27.

5.

Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.

Villeneuve NF, Lau A, Zhang DD.

Antioxid Redox Signal. 2010 Dec 1;13(11):1699-712. doi: 10.1089/ars.2010.3211. Epub 2010 Aug 14. Review.

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A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang DD.

Mol Cell Biol. 2010 Jul;30(13):3275-85. doi: 10.1128/MCB.00248-10. Epub 2010 Apr 26.

10.

Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells.

Iso T, Suzuki T, Baird L, Yamamoto M.

Mol Cell Biol. 2016 Nov 28;36(24):3100-3112. Print 2016 Dec 15.

11.

Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation.

Hong F, Sekhar KR, Freeman ML, Liebler DC.

J Biol Chem. 2005 Sep 9;280(36):31768-75. Epub 2005 Jun 28.

12.

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.

Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, Hirohashi S.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13568-73. doi: 10.1073/pnas.0806268105. Epub 2008 Aug 29. Erratum in: Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10393.

13.

The Keap1-Nrf2 system as an in vivo sensor for electrophiles.

Uruno A, Motohashi H.

Nitric Oxide. 2011 Aug 1;25(2):153-60. doi: 10.1016/j.niox.2011.02.007. Epub 2011 Mar 6.

PMID:
21385624
14.

p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex.

Tao S, Liu P, Luo G, Rojo de la Vega M, Chen H, Wu T, Tillotson J, Chapman E, Zhang DD.

Mol Cell Biol. 2017 Mar 31;37(8). pii: e00660-16. doi: 10.1128/MCB.00660-16. Print 2017 Apr 15.

PMID:
28115426
15.

Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells.

Baird L, Dinkova-Kostova AT.

Biochem Biophys Res Commun. 2013 Mar 29;433(1):58-65. doi: 10.1016/j.bbrc.2013.02.065. Epub 2013 Feb 26.

PMID:
23454126
17.

Keap1 degradation by autophagy for the maintenance of redox homeostasis.

Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, Yamamoto M.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13561-6. doi: 10.1073/pnas.1121572109. Epub 2012 Aug 7.

18.

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.

Taguchi K, Motohashi H, Yamamoto M.

Genes Cells. 2011 Feb;16(2):123-40. doi: 10.1111/j.1365-2443.2010.01473.x. Review.

19.

Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer.

Martinez VD, Vucic EA, Thu KL, Pikor LA, Hubaux R, Lam WL.

Biomed Res Int. 2014;2014:159459. doi: 10.1155/2014/159459. Epub 2014 Jul 9.

20.

Cysteine-based regulation of the CUL3 adaptor protein Keap1.

Sekhar KR, Rachakonda G, Freeman ML.

Toxicol Appl Pharmacol. 2010 Apr 1;244(1):21-6. doi: 10.1016/j.taap.2009.06.016. Epub 2009 Jun 26. Review.

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